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2015ADP-stimulated contraction: A predictor of thin-filament activation in cardiac diseaseDos Remedios, Cristobal Guillermo; Kuster, Diederik; Michels, Michelle; Najafi, Aref; Sequeira, Vasco; van der Velden, Jolanda; Wijnker, Paul; School of Medical Sciences: Bosch InstituteADP-stimulated contraction: A predictor of thin-filament activation in cardiac disease, Proceedings of the National Academy of Sciences of the United States of America (PNAS), vol.112, 50, 2015,pp e7003-e7012
2009Cardiac myosin-binding protein C mutations and hypertrophic ardiomyopathy haploinsufficiency, deranged phosphorylation, and cardiomyocyte dysfunctionDos Remedios, Cristobal Guillermo; Carrier, Lucie; Dooijes, Dennis; Lamers, Jos; Michels, Michelle; Schlossarek, Saskia; Stienen, Ger J.M.; ten Cate, Folkert; van der Velden, Jolanda; Van Dijk, Sabine; Winegrad, Saul; School of Medical Sciences: Bosch InstituteCardiac myosin-binding protein C mutations and hypertrophic ardiomyopathy haploinsufficiency, deranged phosphorylation, and cardiomyocyte dysfunction, Circulation, vol.119, 11, 2009,pp 1473-1483
2018Contribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial HypertensionDos Remedios, Cristobal Guillermo; Bogaard, Harm-Jan; Casali, Adenauer G.; Casali, Karina Rabello; da Silva Goncalves, Bos Denielli; de Man, Frances S.; Dorfmuller, Peter; Goumans, Marie-Jose; Guignabert, Christophe; Handoko, M. Louis; Humbert, Marc; Kurakula, Kondababu; Kuster, Diederik; Rol, Nina; Sun, Xiao-Qing; Szulcek, Robert; Tu, Ly; van Der Bruggen, Cathelijne E.; van der Velden, Jolanda; Vonk-Noordegraaf, Anton; Wijnker, Paul J. M.; School of Medical Sciences: Bosch InstituteContribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension, Circulation, vol.137, 9, 2018,pp 910-924
2018Contribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial HypertensionDos Remedios, Cristobal Guillermo; Bogaard, Harm-Jan; Casali, Adenauer G.; Casali, Karina Rabello; da Silva Goncalves, Bos Denielli; de Man, Frances S.; Dorfmuller, Peter; Goumans, Marie-Jose; Guignabert, Christophe; Handoko, M. Louis; Humbert, Marc; Kurakula, Kondababu; Kuster, Diederik; Rol, Nina; Sun, Xiao-Qing; Szulcek, Robert; Tu, Ly; van Der Bruggen, Cathelijne E.; van der Velden, Jolanda; Vonk-Noordegraaf, Anton; Wijnker, Paul J. M.; School of Medical Sciences: Bosch InstituteContribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension, Circulation, vol.137, 9, 2018,pp 910-924
2018Contribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial HypertensionDos Remedios, Cristobal Guillermo; Bogaard, Harm-Jan; Casali, Adenauer G.; Casali, Karina Rabello; da Silva Goncalves, Bos Denielli; de Man, Frances S.; Dorfmuller, Peter; Goumans, Marie-Jose; Guignabert, Christophe; Handoko, M. Louis; Humbert, Marc; Kurakula, Kondababu; Kuster, Diederik; Rol, Nina; Sun, Xiao-Qing; Szulcek, Robert; Tu, Ly; van Der Bruggen, Cathelijne E.; van der Velden, Jolanda; Vonk-Noordegraaf, Anton; Wijnker, Paul J. M.; School of Medical Sciences: Bosch InstituteContribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension, Circulation, vol.137, 9, 2018,pp 910-924
2018Contribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial HypertensionDos Remedios, Cristobal Guillermo; Bogaard, Harm-Jan; Casali, Adenauer G.; Casali, Karina Rabello; da Silva Goncalves, Bos Denielli; de Man, Frances S.; Dorfmuller, Peter; Goumans, Marie-Jose; Guignabert, Christophe; Handoko, M. Louis; Humbert, Marc; Kurakula, Kondababu; Kuster, Diederik; Rol, Nina; Sun, Xiao-Qing; Szulcek, Robert; Tu, Ly; van Der Bruggen, Cathelijne E.; van der Velden, Jolanda; Vonk-Noordegraaf, Anton; Wijnker, Paul J. M.; School of Medical Sciences: Bosch InstituteContribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension, Circulation, vol.137, 9, 2018,pp 910-924
2018Contribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial HypertensionDos Remedios, Cristobal Guillermo; Bogaard, Harm-Jan; Casali, Adenauer G.; Casali, Karina Rabello; da Silva Goncalves, Bos Denielli; de Man, Frances S.; Dorfmuller, Peter; Goumans, Marie-Jose; Guignabert, Christophe; Handoko, M. Louis; Humbert, Marc; Kurakula, Kondababu; Kuster, Diederik; Rol, Nina; Sun, Xiao-Qing; Szulcek, Robert; Tu, Ly; van Der Bruggen, Cathelijne E.; van der Velden, Jolanda; Vonk-Noordegraaf, Anton; Wijnker, Paul J. M.; School of Medical Sciences: Bosch InstituteContribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension, Circulation, vol.137, 9, 2018,pp 910-924
2018Contribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial HypertensionDos Remedios, Cristobal Guillermo; Bogaard, Harm-Jan; Casali, Adenauer G.; Casali, Karina Rabello; da Silva Goncalves, Bos Denielli; de Man, Frances S.; Dorfmuller, Peter; Goumans, Marie-Jose; Guignabert, Christophe; Handoko, M. Louis; Humbert, Marc; Kurakula, Kondababu; Kuster, Diederik; Rol, Nina; Sun, Xiao-Qing; Szulcek, Robert; Tu, Ly; van Der Bruggen, Cathelijne E.; van der Velden, Jolanda; Vonk-Noordegraaf, Anton; Wijnker, Paul J. M.; School of Medical Sciences: Bosch InstituteContribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension, Circulation, vol.137, 9, 2018,pp 910-924
2018Contribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial HypertensionDos Remedios, Cristobal Guillermo; Bogaard, Harm-Jan; Casali, Adenauer G.; Casali, Karina Rabello; da Silva Goncalves, Bos Denielli; de Man, Frances S.; Dorfmuller, Peter; Goumans, Marie-Jose; Guignabert, Christophe; Handoko, M. Louis; Humbert, Marc; Kurakula, Kondababu; Kuster, Diederik; Rol, Nina; Sun, Xiao-Qing; Szulcek, Robert; Tu, Ly; van Der Bruggen, Cathelijne E.; van der Velden, Jolanda; Vonk-Noordegraaf, Anton; Wijnker, Paul J. M.; School of Medical Sciences: Bosch InstituteContribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension, Circulation, vol.137, 9, 2018,pp 910-924
2018Contribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial HypertensionDos Remedios, Cristobal Guillermo; Bogaard, Harm-Jan; Casali, Adenauer G.; Casali, Karina Rabello; da Silva Goncalves, Bos Denielli; de Man, Frances S.; Dorfmuller, Peter; Goumans, Marie-Jose; Guignabert, Christophe; Handoko, M. Louis; Humbert, Marc; Kurakula, Kondababu; Kuster, Diederik; Rol, Nina; Sun, Xiao-Qing; Szulcek, Robert; Tu, Ly; van Der Bruggen, Cathelijne E.; van der Velden, Jolanda; Vonk-Noordegraaf, Anton; Wijnker, Paul J. M.; School of Medical Sciences: Bosch InstituteContribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension, Circulation, vol.137, 9, 2018,pp 910-924
2018Contribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial HypertensionDos Remedios, Cristobal Guillermo; Bogaard, Harm-Jan; Casali, Adenauer G.; Casali, Karina Rabello; da Silva Goncalves, Bos Denielli; de Man, Frances S.; Dorfmuller, Peter; Goumans, Marie-Jose; Guignabert, Christophe; Handoko, M. Louis; Humbert, Marc; Kurakula, Kondababu; Kuster, Diederik; Rol, Nina; Sun, Xiao-Qing; Szulcek, Robert; Tu, Ly; van Der Bruggen, Cathelijne E.; van der Velden, Jolanda; Vonk-Noordegraaf, Anton; Wijnker, Paul J. M.; School of Medical Sciences: Bosch InstituteContribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension, Circulation, vol.137, 9, 2018,pp 910-924
2018Contribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial HypertensionDos Remedios, Cristobal Guillermo; Bogaard, Harm-Jan; Casali, Adenauer G.; Casali, Karina Rabello; da Silva Goncalves, Bos Denielli; de Man, Frances S.; Dorfmuller, Peter; Goumans, Marie-Jose; Guignabert, Christophe; Handoko, M. Louis; Humbert, Marc; Kurakula, Kondababu; Kuster, Diederik; Rol, Nina; Sun, Xiao-Qing; Szulcek, Robert; Tu, Ly; van Der Bruggen, Cathelijne E.; van der Velden, Jolanda; Vonk-Noordegraaf, Anton; Wijnker, Paul J. M.; School of Medical Sciences: Bosch InstituteContribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension, Circulation, vol.137, 9, 2018,pp 910-924
2015Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin geneClarke, Nigel; Beggs, Alan H.; de Winter, Josine Marieke; Granzier, Henk; Joureau, Barbara; Ottenheijm, Coen; Sequeira, Vasco; Stienen, Ger J.M.; van der Velden, Jolanda; Childrens Hospital Westmead: Paediatrics & Child HealthEffect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene, Skeletal Muscle, vol.5, N/A, 2015,pp 1-10
2010Effect of troponin I Ser23/24 phosphorylation on Ca2+-sensitivity in human myocardium depends on the phosphorylation background.dos Remedios, Cristobal; Foster, D. Brian; Jaquet, Kornelia; Kooij, Viola; Murphy, Anne; Saes, Martina; Stienen, Ger J.M.; van der Velden, Jolanda; Zaremba, Ruud; School of Medical Sciences: Anatomy & HistologyEffect of troponin I Ser23/24 phosphorylation on Ca2+-sensitivity in human myocardium depends on the phosphorylation background., Journal of Molecular and Cellular Cardiology, vol.48, 5,pp 954-963
2013GSK3β phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: Short communicationDos Remedios, Cristobal Guillermo; Boontje, Nicky M.; Carrier, Lucie; Demmers, Jeroen; Kuster, Diederik; Marston, Steven; Najafi, Aref; Paalberends, Rosalie; Redwood, Charles; Sadayappan, Sakthivel; Sequeira, Vasco; van der Velden, Jolanda; Wijnker, Paul; School of Medical Sciences: Bosch InstituteGSK3β phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: Short communication, Circulation Research, vol.112, 4, 2013,pp 633-639
2013Impact of site-specific phosphorylation of protein kinase A sites Ser23 and Ser24 of cardiac troponin I in human cardiomyocytesdos Remedios, Cristobal; Foster, D. Brian; Frazier, Aisha H; Murphy, Anne M; Stienen, Ger J.M.; Tsao, Allison L; van der Velden, Jolanda; Wijnker, Paul; School of Medical Sciences: Bosch InstituteImpact of site-specific phosphorylation of protein kinase A sites Ser23 and Ser24 of cardiac troponin I in human cardiomyocytes, AmJP:Heart and Circulatory Physiology, vol.304, 2, 2013,pp H260-H268
2014Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylationDos Remedios, Cristobal Guillermo; Foster, D. Brian; Li, Yuejin; Murphy, Anne M; Sequeira, Vasco; Stienen, Ger J.M.; van der Velden, Jolanda; Wijnker, Paul; School of Medical Sciences: Bosch InstituteLength-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation, American Journal of Physiology:Heart and Circulatory Physiology, vol.306, 8, 2014,pp H1171-H1181
2013MicroRNA transcriptome profiling in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutationsdos Remedios, Cristobal; da Costa Martins, Paula A; Kuster, Diederik; Michels, Michelle; Mulders, Joyce; Oudejans, Cees B M; Ten Cate, Folkert; van der Velden, Jolanda; School of Medical Sciences: Bosch InstituteMicroRNA transcriptome profiling in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutations, Journal of Molecular and Cellular Cardiology, vol.65, N/A, 2013,pp 59-66
2010More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart diseasedos Remedios, Cristobal; Borbely, Attila; Hamdani, Nazha; Kooij, Viola; Michel, Martin; Niessen, Hans; Paulus, Walter; Stienen, Ger J.M.; van der Velden, Jolanda; Veenstra, Sophie; Vrydag, Wim; Zaremba, Ruud; School of Medical Sciences: Anatomy & HistologyMore severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease, Journal Of Muscle Research And Cell Motility, vol.31, 4,pp 289-301
2017MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathyDos Remedios, Cristobal Guillermo; Lal, Sean; McNamara, James; Ackerman, Michael; Bos, J; Cooke, Roger; Harris, Samantha; Li, Amy; van der Velden, Jolanda; School of Medical Sciences: Bosch Institute; School of Medical Sciences: Anatomy & Histology; School of Medical Sciences: Anatomy & HistologyMYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy, PloS One, vol.12, 6, 2017,pp 1-22