Browsing by Author Wijnker, Paul

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Issue DateTitleAuthor(s)Citation
2015ADP-stimulated contraction: A predictor of thin-filament activation in cardiac diseaseDos Remedios, Cristobal Guillermo; Kuster, Diederik; Michels, Michelle; Najafi, Aref; Sequeira, Vasco; van der Velden, Jolanda; Wijnker, Paul; School of Medical Sciences: Bosch InstituteADP-stimulated contraction: A predictor of thin-filament activation in cardiac disease, Proceedings of the National Academy of Sciences of the United States of America (PNAS), vol.112, 50, 2015,pp e7003-e7012
2013GSK3β phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: Short communicationDos Remedios, Cristobal Guillermo; Boontje, Nicky M.; Carrier, Lucie; Demmers, Jeroen; Kuster, Diederik; Marston, Steven; Najafi, Aref; Paalberends, Rosalie; Redwood, Charles; Sadayappan, Sakthivel; Sequeira, Vasco; van der Velden, Jolanda; Wijnker, Paul; School of Medical Sciences: Bosch InstituteGSK3β phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: Short communication, Circulation Research, vol.112, 4, 2013,pp 633-639
2013Impact of site-specific phosphorylation of protein kinase A sites Ser23 and Ser24 of cardiac troponin I in human cardiomyocytesdos Remedios, Cristobal; Foster, D. Brian; Frazier, Aisha H; Murphy, Anne M; Stienen, Ger J.M.; Tsao, Allison L; van der Velden, Jolanda; Wijnker, Paul; School of Medical Sciences: Bosch InstituteImpact of site-specific phosphorylation of protein kinase A sites Ser23 and Ser24 of cardiac troponin I in human cardiomyocytes, AmJP:Heart and Circulatory Physiology, vol.304, 2, 2013,pp H260-H268
2014Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylationDos Remedios, Cristobal Guillermo; Foster, D. Brian; Li, Yuejin; Murphy, Anne M; Sequeira, Vasco; Stienen, Ger J.M.; van der Velden, Jolanda; Wijnker, Paul; School of Medical Sciences: Bosch InstituteLength-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation, American Journal of Physiology:Heart and Circulatory Physiology, vol.306, 8, 2014,pp H1171-H1181
2015A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysisDos Remedios, Cristobal Guillermo; Foster, Brian; Li, Yuejin; Murphy, Anne; Stienen, Ger J.M.; van der Velden, Jolanda; van Eyk, Jennifer E.; Wijnker, Paul; Zhang, Pingbo; School of Medical Sciences: Bosch InstituteA novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis, Journal of Molecular and Cellular Cardiology, vol.82, N/A, 2015,pp 93-103
2013Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutationsdos Remedios, Cristobal; Boontje, Nicky M.; Carrier, Lucie; Foster, D. Brian; Germans, T; Ho, Carolyn Y; Kuster, Diederik; Michels, Michelle; Murphy, Anne M; Najafi, Aref; Nijenkamp, L L A M; Poggesi, Corrado; Regan, J A; Sadayappan, Sakthivel; Sequeira, Vasco; Stienen, Ger J.M.; Ten Cate, F J; van der Velden, Jolanda; van Slegtenhorst, Marjon; Wijnker, Paul; Witjas-Paalberends, E R; Zaremba, Ruud; School of Medical Sciences: Bosch InstitutePerturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations, Circulation Research, vol.112, 11, 2013,pp 1491-1505
2014Phosphorylation of protein kinase C sites Ser42/44 decreases Ca 2+-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytesDos Remedios, Cristobal Guillermo; Foster, D. Brian; Murphy, Anne; Sequeira, Vasco; Stienen, Ger J.M.; van der Velden, Jolanda; Wijnker, Paul; Witjas-Paalberends, E R; School of Medical Sciences: Bosch InstitutePhosphorylation of protein kinase C sites Ser42/44 decreases Ca 2+-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes, Archives of Biochemistry and Biophysics, vol.15, 554, 2014,pp 11-21
2013PKCα-Specific Phosphorylation of the Troponin Complex in Human Myocardium: A Functional and Proteomics Analysisdos Remedios, Cristobal; Boontje, Nicky M.; Jaquet, Kornelia; Jimenez, Connie; Kooij, Viola; Murphy, Anne M; Piersma, Sander; Sequeira, Vasco; Stienen, Ger J.M.; van der Velden, Jolanda; van Eyk, Jennifer E.; Wijnker, Paul; Zhang, Pingbo; School of Medical Sciences: Bosch InstitutePKCα-Specific Phosphorylation of the Troponin Complex in Human Myocardium: A Functional and Proteomics Analysis, PLoS One, vol.8, 10, 2013,pp 1-10
2011Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardiumdos Remedios, Cristobal; Boknik, Peter; Gergs, Ulrich; Kirchhefer, Uwe; Muller, Frank; Neumann, Joachim; Schmitz, Wilhelm; Sindermann, Jurgen; Stienen, Ger J.M.; van der Velden, Jolanda; Wijnker, Paul; School of Medical Sciences: Bosch InstituteProtein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium, Journal Of Muscle Research And Cell Motility, vol.32, 3, 2011,pp 221-233