Browsing by Author Wakelin, Laurence P G

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Showing results 1 to 6 of 6
Issue DateTitleAuthor(s)Citation
2002Crystal structure of 9-amino-N-[2-(4-morpholinyl)ethyl]-4-acridinecarboxamide bound to d(CGTACG)2: implications for structure-activity relationships of acridinecarboxamide topoisimerase poisonsAdams, Adrienne; Guss, Jules Mitchell; Denny, William A; Wakelin, Laurence P G; Molecular & Microbial Bioscien; Molecular & Microbial BioscienCrystal structure of 9-amino-N-[2-(4-morpholinyl)ethyl]-4-acridinecarboxamide bound to d(CGTACG)2: implications for structure-activity relationships of acridinecarboxamide topoisimerase poisons, Nucleic Acids Research, vol.30,(3),2002,pp 719-725
2009In vitro assessment of novel transcription inhibitors and topoisomerase poisons in rhabdomyosarcoma cell linesCatchpoole, Daniel; Wolf, Steven; He, Zhicong; Stewart, Bernard W.; Wakelin, Laurence P G; Children's Hospital Westmead: Paediatrics & Child Health; Children's Hospital Westmead: Paediatrics & Child HealthIn vitro assessment of novel transcription inhibitors and topoisomerase poisons in rhabdomyosarcoma cell lines, Cancer Chemotherapy and Pharmacology, vol.64, 6, 2009,pp 1059-1069
2011Intracellular trafficking as a determinant of AS-DACA cytotoxicity in rhabdomyosarcoma cellsBryce, Nicole; Catchpoole, Daniel; Hambley, Trevor; Wolf, Steven; Huynh, Tony; Stewart, Bernard W.; Wakelin, Laurence P G; Chemistry; Children's Hospital Westmead: Paediatrics & Child Health; Chemistry; Children's Hospital Westmead: Paediatrics & Child HealthIntracellular trafficking as a determinant of AS-DACA cytotoxicity in rhabdomyosarcoma cells, BMC Cell Biology, vol.12, 36, 2011,pp 1-11
2002Kinetic Studies of the Binding of Acridinecarboxamide Topoisomerase Poisons to DNA: Implications for Mode of Binding of Ligands with Uncharged ChromophoresAdams, Adrienne; Denny, William A; Wakelin, Laurence P G; Molecular & Microbial BioscienKinetic Studies of the Binding of Acridinecarboxamide Topoisomerase Poisons to DNA: Implications for Mode of Binding of Ligands with Uncharged Chromophores, Journal of Medicinal Chemistry, vol.45,(4),2002,pp 894-901
2002Structural characterisation of bisintercalation in higher-order DNA at a junction-like quadruplexAdams, Adrienne; Cardin, Christine J; Denny, William A; Powell, Harold R; Teixeira, Susana C M; Thorpe, James H; Todd, Alan K; Wakelin, Laurence P G; Molecular & Microbial BioscienStructural characterisation of bisintercalation in higher-order DNA at a junction-like quadruplex, Journal of Molecular Biology, vol.323,(2),2002,pp 167-171
2004Structure Of 9-Amino- N-(2-Dimethylamino)Propyl Acridine-4-Carboxamide Bound To D(Cgtacg)(2): A Comparison Of Structures Of D(Cgtacg)(2) Complexed With Intercalators In The Presence Of CobaltAdams, Adrienne; Guss, Jules Mitchell; Denny, William A; Wakelin, Laurence P G; School of Molecular Bioscience; School of Molecular BioscienceStructure Of 9-Amino- N-(2-Dimethylamino)Propyl Acridine-4-Carboxamide Bound To D(Cgtacg)(2): A Comparison Of Structures Of D(Cgtacg)(2) Complexed With Intercalators In The Presence Of Cobalt, Acta Crystallographica. Section D: Biological Crystallography, vol.60,(5),2004,pp 823-828