Browsing by Author Tembe, Varsha

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Issue DateTitleAuthor(s)Citation
2015The BARD1 BRCT domain contributes to p53 binding, cytoplasmic and mitochondrial localization, and apoptotic functionBrodie, Kirsty Maree; deFazio, Anna; Henderson, Beric; Lei, Ying; Martino-Echarri, Estefania; Marzec, Kamila; Mills, Kate; Mok, Myth; Rizos, Helen; Tembe, Varsha; Boadle, Ross; Kettle, Emma; Western Clinical School: Westmead Institute for Medical Res; Western Clinical School: Westmead Institute for Medical Res; Western Clinical School: Westmead Institute for Medical Res; Medicine; Western Clinical School: Westmead Institute for Medical Res; Research Grants and Contracts; Western Clinical School: Medicine (Westmead); Western Clinical School: Medicine (Westmead); Western Clinical School: Westmead Institute for Medical Res; Western Clinical School: Westmead Institute for Medical ResThe BARD1 BRCT domain contributes to p53 binding, cytoplasmic and mitochondrial localization, and apoptotic function, Cellular Signalling, vol.27, 9, 2015,pp 1763-1771
2007BARD1 Translocation to Mitochondria Correlates with Bax Oligomerization, Loss of Mitochondrial Membrane Potential, and ApoptosisHenderson, Beric; Tembe, Varsha; Western Clinical School: Westmead Millennium Institute; Western Clinical School: Medicine (Westmead)BARD1 Translocation to Mitochondria Correlates with Bax Oligomerization, Loss of Mitochondrial Membrane Potential, and Apoptosis, Journal of Biological Chemistry, vol.282,(28),2007,pp 20513-20522
2015Circulating tumor DNA to monitor treatment response and detect acquired resistance in patients with metastatic melanomaCarlino, Matteo; Lee, Jenny H J; Long, Georgina; Scolyer, Richard; Tembe, Varsha; Boyd, Suzanah C; Cooper, Adam; et al, Various; Freeman, James; Gray, Elin S; Khattak, Muhammad A; Lo, Johnny; Lomma, Chris; Pereira, Michelle R; Reid, Anna L; Rizos, Helen; Siew, Kelvin; Western Clinical School: Medicine (Westmead); Western Clinical School: Westmead Institute for Medical Res; Central Clinical School: The Sydney Cancer Centre; Central Clinical School: Pathology; Western Clinical School: Westmead Institute for Medical ResCirculating tumor DNA to monitor treatment response and detect acquired resistance in patients with metastatic melanoma, Oncotarget, vol.N/A, N/A, 2015,pp N/A-N/A
2013Effects of BRAF inhibitors on human melanoma tissue before treatment, early during treatment and on progressionHaydu, Lauren; Howle, Julie; Kefford, Richard (Rick); Long, Georgina; Rizos, Helen; Scolyer, Richard; Sharma, Raghwa; Tembe, Varsha; Thompson, John; Wilmott, James; Central Clinical School: Surgery; Western Clinical School: Surgery; Western Clinical School: Westmead Millennium Institute; Central Clinical School: The Sydney Cancer Centre; Western Clinical School: Westmead Millennium Institute; Central Clinical School: Pathology; Western Clinical School: Pathology; Western Clinical School: Medicine (Westmead); Central Clinical School: Surgery; Central Clinical School: SurgeryEffects of BRAF inhibitors on human melanoma tissue before treatment, early during treatment and on progression, Pigment Cell and Melanoma Research, vol.26, 4, 2013,pp 499-508
2012A high-throughput panel for identifying clinically relevant mutation profiles in melanomaCarter, Candace; Mann, Graham; Pupo, Gulietta; Scolyer, Richard; Tembe, Varsha; Aoude, Lauren G; Dutton-Regester, Ken; et al, various; Hunt, Priscilla; Irwin, Darryl; Lanagan, Cathy; O'Connor, Linda; O'Rourke, Michael; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Western Clinical School: Westmead Millennium Institute; Western Clinical School: Medicine (Westmead); Central Clinical School: Pathology; Western Clinical School: Medicine (Westmead)A high-throughput panel for identifying clinically relevant mutation profiles in melanoma, Molecular Cancer Therapeutics, vol.11, 4, 2012,pp 888-897
2012Identification of TFG (TRK-Fused Gene) as a Putative Metastatic Melanoma Tumor Suppressor GeneMann, Graham; Pupo, Gulietta; Scolyer, Richard; Tembe, Varsha; Aoude, Lauren G; Carter, Candace; Dutton-Regester, Ken; et al, various; Lanagan, Cathy; Nancarrow, Derek J.; O'Connor, Linda; O'Rourke, Michael; Stark, Mitchell; Western Clinical School: Westmead Millennium Institute; Western Clinical School: Medicine (Westmead); Central Clinical School: Pathology; Western Clinical School: Medicine (Westmead)Identification of TFG (TRK-Fused Gene) as a Putative Metastatic Melanoma Tumor Suppressor Gene, Genes Chromosomes and Cancer, vol.51, 5, 2012,pp 452-461
2016Identification, Review, and Systematic Cross-Validation of microRNA Prognostic Signatures in Metastatic MelanomaJayawardana, Kaushala; Mann, Graham; Mueller, Samuel; Schramm, Sarah-Jane; Scolyer, Richard; Tembe, Varsha; Thompson, John; Yang, Jean Yee Hwa; Mathematics & Statistics; Western Clinical School: Westmead Institute for Medical Res; Mathematics & Statistics; Western Clinical School: Medicine (Westmead); Central Clinical School: Pathology; Western Clinical School: Westmead Institute for Medical Res; Central Clinical School: Surgery; Mathematics & StatisticsIdentification, Review, and Systematic Cross-Validation of microRNA Prognostic Signatures in Metastatic Melanoma, Journal of Investigative Dermatology, vol.136, 1, 2016,pp 245-254
2014Increased MAPK reactivation in early resistance to dabrafenib/trametinib combination therapy of BRAF-mutant metastatic melanomaCarlino, Matteo; Fung, Carina; Howle, Julie; Kefford, Richard (Rick); Long, Georgina; Menzies, Alexander Maxwel; Pupo, Gulietta; Rizos, Helen; Saw, Robyn; Scolyer, Richard; Shahheydari, Hamideh; Tembe, Varsha; Thompson, John; Hayward, Nicholas K; Hyman, Jessica; Johansson, Peter; Western Clinical School: Medicine (Westmead); Infectious Diseases; Western Clinical School: Surgery; Western Clinical School: Westmead Millennium Institute; Central Clinical School: The Sydney Cancer Centre; Central Clinical School: Medicine; Western Clinical School: Medicine (Westmead); Western Clinical School: Westmead Millennium Institute; Central Clinical School: Surgery; Central Clinical School: Pathology; Western Clinical School: Medicine (Westmead); Western Clinical School: Medicine (Westmead); Central Clinical School: SurgeryIncreased MAPK reactivation in early resistance to dabrafenib/trametinib combination therapy of BRAF-mutant metastatic melanoma, Nature Communications, vol.5, N/A, 2014,pp 1-9
2012Intratumoral Molecular Heterogeneity in a BRAF-Mutant, BRAF Inhibitor-Resistant Melanoma: A Case Illustrating the Challenges for Personalized MedicineHowle, Julie; Kefford, Richard (Rick); Long, Georgina; Rizos, Helen; Scolyer, Richard; Tembe, Varsha; Thompson, John; Wilmott, James; Lo, Roger; Sharma, Raghwa; Western Clinical School: Surgery; Western Clinical School: Westmead Millennium Institute; Central Clinical School: The Sydney Cancer Centre; Western Clinical School: Westmead Millennium Institute; Central Clinical School: Pathology; Western Clinical School: Medicine (Westmead); Central Clinical School: Surgery; Central Clinical School: SurgeryIntratumoral Molecular Heterogeneity in a BRAF-Mutant, BRAF Inhibitor-Resistant Melanoma: A Case Illustrating the Challenges for Personalized Medicine, Molecular Cancer Therapeutics, vol.11, 12, 2012,pp 2704-2708
2004Issues Arising From The Prenatal Diagnosis Of Some Rare Trisomy Mosaics--The Importance Of Cryptic Fetal Mosaicism.Ades, Lesley; Daniel, Art; Darmanian, Artur; Kennedy, Craig; Malafiej, Paul; Peters, Gregory; Tembe, Varsha; Wu, Zhanhe; Children's Hospital Westmead: Paediatrics & Child Health; Children's Hospital Westmead: Paediatrics & Child Health; Medicine; Western Clinical School: Obstetrics & Gynaecology; Children's Hospital Westmead: Paediatrics & Child Health; Children's Hospital Westmead: Paediatrics & Child Health; Western Clinical School: Medicine (Westmead); Western Clinical School: Obstetrics & GynaecologyIssues Arising From The Prenatal Diagnosis Of Some Rare Trisomy Mosaics--The Importance Of Cryptic Fetal Mosaicism., Prenatal diagnosis, vol.24,(7),2004,pp 524-536
2015microRNA and mRNA expression profiling in metastatic melanoma reveal associations with BRAF mutation and patient prognosisJayaswal, Vivek; Mann, Graham; Patrick, Ellis; Schramm, Sarah-Jane; Scolyer, Richard; Tembe, Varsha; Thompson, John; Yang, Jean Yee Hwa; Barbour, Andrew; Hayward, Nicholas K; Stark, Mitchell; Tang, Yue Hang; Mathematics & Statistics; Western Clinical School: Westmead Millennium Institute; Mathematics & Statistics; Western Clinical School: Medicine (Westmead); Central Clinical School: Pathology; Western Clinical School: Medicine (Westmead); Central Clinical School: Surgery; Mathematics & StatisticsmicroRNA and mRNA expression profiling in metastatic melanoma reveal associations with BRAF mutation and patient prognosis, Pigment Cell & Melanoma Research, vol.28, 3, 2015,pp 254-226
2012Mutational analysis of cutaneous squamous cell carcinomas and verrucal keratosis in patients taking braf inhibitorsAnforth, Rachael; Blumetti, Tatiana; Fernandez-Penas, Pablo; Tembe, Varsha; Western Clinical School: Medicine (Westmead); Western Clinical School: Medicine (Westmead); Western Clinical School: Medicine (Westmead)Mutational analysis of cutaneous squamous cell carcinomas and verrucal keratosis in patients taking braf inhibitors, Pigment Cell and Melanoma Research, vol.25, 5, 2012,pp 569-572
2005Nuclear targeting and cell cycle regulatory function of human BARD1.Henderson, Beric; Tembe, Varsha; Rodriguez, Jose┬┤ Antonio; Sch├╝chner, Stefan; Western Clinical School: Westmead Millennium Institute; Western Clinical School: Medicine (Westmead)Nuclear targeting and cell cycle regulatory function of human BARD1., Journal of Biological Chemistry, vol.280,(10),2005,pp 8855-8861
2007Protein trafficking in response to DNA damageHenderson, Beric; Tembe, Varsha; Western Clinical School: Westmead Millennium Institute; Western Clinical School: Medicine (Westmead)Protein trafficking in response to DNA damage, Cellular Signalling, vol.19,(6),2007,pp 1113-1120
2015Tumour procurement, DNA extraction, coverage analysis and optimisation of mutation-detection algorithms for human melanoma genomesKakavand, Hojabr; Mann, Graham; Pupo, Gulietta; Scolyer, Richard; Tembe, Varsha; Thompson, John; Vilain, Ricardo; Wilmott, James; Cebon, Jonathan; De Paoli-Iseppi, Ricardo; Field, Matthew; Fitzgerald, Anna; Hayward, Nicholas K; Jakrot, Valerie; Johansson, Peter; Shackleton, Mark; Shang, Catherine A; Shang, Ping; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Western Clinical School: Westmead Institute for Medical Res; Western Clinical School: Medicine (Westmead); Central Clinical School: Pathology; Western Clinical School: Westmead Institute for Medical Res; Central Clinical School: Surgery; Central Clinical School: Pathology; Central Clinical School: SurgeryTumour procurement, DNA extraction, coverage analysis and optimisation of mutation-detection algorithms for human melanoma genomes, Pathology, vol.47, 7, 2015,pp 683-693
2017Whole-genome landscapes of major melanoma subtypesBurke, Hazel; Dagg, Rebecca; De Paoli-Iseppi, Ricardo; Hayward, Nicholas; Hersey, Peter; Jakrot, Valerie; Kakavand, Hojabr; Kefford, Richard (Rick); Lau, Loretta; Long, Georgina; Mann, Graham; Pickett, Hilda; Pupo, Gulietta; Saw, Robyn; Schramm, Sarah-Jane; Scolyer, Richard; Shang, Ping; Spillane, Andrew; Stretch, Jonathan; Tembe, Varsha; Thompson, John; Vilain, Ricardo; Wilmott, James; Yang, Jean Yee Hwa; Alexandrov, L; Behren, A; Cebon, Jonathan Simon; Dutton-Regester, K; Field, M; Fitzgerald, A; Grimmond, Sean Michael; Holmes, O; Johansson, P; Kazakoff, S; Leonard, Conrad; Lopez-Bigas, Nuria; Mularoni, L; Newell, F; Nones, Katia; Patch, Anne-Marie; Pearson, John V; Pritchard, Antonia L; Sabarinathan, R; Shackleton, Mark; Shang, C; Waddell, Nick; Waddell, Nicola; Wood, Scott; Xu, Qingying; Melanoma Foundation; School of Molecular Bioscience (SMB); Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Medicine Faculty Office; Northern Clinical School: Surgery; Northern Clinical School: Medicine; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Western Clinical School: Medicine (Westmead); Childrens Hospital Westmead: Paediatrics & Child Health; Northern Clinical School: Medicine; Western Clinical School: Westmead Institute for Medical Res; Childrens Medical Research Institute (CMRI); Western Clinical School: Medicine (Westmead); Central Clinical School: Surgery; Western Clinical School: Medicine (Westmead); Central Clinical School: Pathology; Northern Clinical School: Kolling Institute; Northern Clinical School: Surgery; Central Clinical School: Surgery; Western Clinical School: Westmead Institute for Medical Res; Central Clinical School: Surgery; Central Clinical School: Pathology; Central Clinical School: Surgery; Mathematics & StatisticsWhole-genome landscapes of major melanoma subtypes, Nature, vol.545, 7653, 2017,pp 175-180