Browsing by Author Stienen, Ger J.M.

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Showing results 1 to 19 of 19
Issue DateTitleAuthor(s)Citation
2009Cardiac myosin-binding protein C mutations and hypertrophic ardiomyopathy haploinsufficiency, deranged phosphorylation, and cardiomyocyte dysfunctionDos Remedios, Cristobal Guillermo; Carrier, Lucie; Dooijes, Dennis; Lamers, Jos; Michels, Michelle; Schlossarek, Saskia; Stienen, Ger J.M.; ten Cate, Folkert; van der Velden, Jolanda; Van Dijk, Sabine; Winegrad, Saul; School of Medical Sciences: Bosch InstituteCardiac myosin-binding protein C mutations and hypertrophic ardiomyopathy haploinsufficiency, deranged phosphorylation, and cardiomyocyte dysfunction, Circulation, vol.119, 11, 2009,pp 1473-1483
2014Contractile dysfunction of left ventricular cardiomyocytes in patients with pulmonary arterial hypertensionDos Remedios, Cristobal Guillermo; Bogaard, Harm-Jan; Dorfmuller, Peter; et al, .; Fadel, Elie; Handoko, Louis; Humbert, Marc; Keogh, Anne M; Manders, Emmy; Stienen, Ger J.M.; Van De Veerdonk, Marielle; Westerhof, Nico; School of Medical Sciences: Bosch InstituteContractile dysfunction of left ventricular cardiomyocytes in patients with pulmonary arterial hypertension, Journal of the American College of Cardiology, vol.64, 1, 2014,pp 28-37
2015Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin geneClarke, Nigel; Beggs, Alan H.; de Winter, Josine Marieke; Granzier, Henk; Joureau, Barbara; Ottenheijm, Coen; Sequeira, Vasco; Stienen, Ger J.M.; van der Velden, Jolanda; Childrens Hospital Westmead: Paediatrics & Child HealthEffect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene, Skeletal Muscle, vol.5, N/A, 2015,pp 1-10
2010Effect of troponin I Ser23/24 phosphorylation on Ca2+-sensitivity in human myocardium depends on the phosphorylation background.dos Remedios, Cristobal; Foster, D. Brian; Jaquet, Kornelia; Kooij, Viola; Murphy, Anne; Saes, Martina; Stienen, Ger J.M.; van der Velden, Jolanda; Zaremba, Ruud; School of Medical Sciences: Anatomy & HistologyEffect of troponin I Ser23/24 phosphorylation on Ca2+-sensitivity in human myocardium depends on the phosphorylation background., Journal of Molecular and Cellular Cardiology, vol.48, 5,pp 954-963
2013Impact of site-specific phosphorylation of protein kinase A sites Ser23 and Ser24 of cardiac troponin I in human cardiomyocytesdos Remedios, Cristobal; Foster, D. Brian; Frazier, Aisha H; Murphy, Anne M; Stienen, Ger J.M.; Tsao, Allison L; van der Velden, Jolanda; Wijnker, Paul; School of Medical Sciences: Bosch InstituteImpact of site-specific phosphorylation of protein kinase A sites Ser23 and Ser24 of cardiac troponin I in human cardiomyocytes, AmJP:Heart and Circulatory Physiology, vol.304, 2, 2013,pp H260-H268
2014Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylationDos Remedios, Cristobal Guillermo; Foster, D. Brian; Li, Yuejin; Murphy, Anne M; Sequeira, Vasco; Stienen, Ger J.M.; van der Velden, Jolanda; Wijnker, Paul; School of Medical Sciences: Bosch InstituteLength-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation, American Journal of Physiology:Heart and Circulatory Physiology, vol.306, 8, 2014,pp H1171-H1181
2010More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart diseasedos Remedios, Cristobal; Borbely, Attila; Hamdani, Nazha; Kooij, Viola; Michel, Martin; Niessen, Hans; Paulus, Walter; Stienen, Ger J.M.; van der Velden, Jolanda; Veenstra, Sophie; Vrydag, Wim; Zaremba, Ruud; School of Medical Sciences: Anatomy & HistologyMore severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease, Journal Of Muscle Research And Cell Motility, vol.31, 4,pp 289-301
2016Mutation-specific effects on thin filament length in thin filament myopathyClarke, Nigel; Yuen, Michaela; de Winter, Josine Marieke; Edvardson, Simon; et al, Various; Gregorio, Carol; Gupta, Vandana; Joureau, Barbara; Kiss, Balazs; Lee, Eun-Jeong; Pappas, Christopher; Stienen, Ger J.M.; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child HealthMutation-specific effects on thin filament length in thin filament myopathy, Annals of Neurology, vol.79, 6, 2016,pp 959-969
2015A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysisDos Remedios, Cristobal Guillermo; Foster, Brian; Li, Yuejin; Murphy, Anne; Stienen, Ger J.M.; van der Velden, Jolanda; van Eyk, Jennifer E.; Wijnker, Paul; Zhang, Pingbo; School of Medical Sciences: Bosch InstituteA novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis, Journal of Molecular and Cellular Cardiology, vol.82, N/A, 2015,pp 93-103
2013Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutationsdos Remedios, Cristobal; Boontje, Nicky M.; Carrier, Lucie; Foster, D. Brian; Germans, T; Ho, Carolyn Y; Kuster, Diederik; Michels, Michelle; Murphy, Anne M; Najafi, Aref; Nijenkamp, L L A M; Poggesi, Corrado; Regan, J A; Sadayappan, Sakthivel; Sequeira, Vasco; Stienen, Ger J.M.; Ten Cate, F J; van der Velden, Jolanda; van Slegtenhorst, Marjon; Wijnker, Paul; Witjas-Paalberends, E R; Zaremba, Ruud; School of Medical Sciences: Bosch InstitutePerturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations, Circulation Research, vol.112, 11, 2013,pp 1491-1505
2014Phosphorylation of protein kinase C sites Ser42/44 decreases Ca 2+-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytesDos Remedios, Cristobal Guillermo; Foster, D. Brian; Murphy, Anne; Sequeira, Vasco; Stienen, Ger J.M.; van der Velden, Jolanda; Wijnker, Paul; Witjas-Paalberends, E R; School of Medical Sciences: Bosch InstitutePhosphorylation of protein kinase C sites Ser42/44 decreases Ca 2+-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes, Archives of Biochemistry and Biophysics, vol.15, 554, 2014,pp 11-21
2013PKCĪ±-Specific Phosphorylation of the Troponin Complex in Human Myocardium: A Functional and Proteomics Analysisdos Remedios, Cristobal; Boontje, Nicky M.; Jaquet, Kornelia; Jimenez, Connie; Kooij, Viola; Murphy, Anne M; Piersma, Sander; Sequeira, Vasco; Stienen, Ger J.M.; van der Velden, Jolanda; van Eyk, Jennifer E.; Wijnker, Paul; Zhang, Pingbo; School of Medical Sciences: Bosch InstitutePKCĪ±-Specific Phosphorylation of the Troponin Complex in Human Myocardium: A Functional and Proteomics Analysis, PLoS One, vol.8, 10, 2013,pp 1-10
2014Preserved cross-bridge kinetics in human hypertrophic cardiomyopathy patients with MYBPC3 mutationsDos Remedios, Cristobal Guillermo; Boontje, Nicky M.; Dooijes, Dennis; Heymans, M W; Michels, Michelle; Stienen, Ger J.M.; ten Cate, Folkert; van der Velden, Jolanda; Van Dijk, Sabine; van Slegtenhorst, Marjon; School of Medical Sciences: Bosch InstitutePreserved cross-bridge kinetics in human hypertrophic cardiomyopathy patients with MYBPC3 mutations, Pfluegers Archiv: European journal of physiology, vol.466, 8, 2014,pp 1619-2633
2014Protein Changes Contributing to Right Ventricular Cardiomyocyte Diastolic Dysfunction in Pulmonary Arterial HypertensionDos Remedios, Cristobal Guillermo; Bogaard, Harm-Jan; da Silva Goncalves Bos, Denielli; de Man, Frances S; Dorfmuller, Peter; Goebel, Max; Granzier, Henk; Guignabert, Christophe; Handoko, Louis; Hidalgo, Carlos; Humbert, Marc; Ottenheijm, Coen; Rain, Silvia; Saripalli, Chandra; Stienen, Ger J.M.; van der Velden, Jolanda; Vonk-Noordegraaf, Anton; Westerhof, Nico; School of Medical Sciences: Bosch InstituteProtein Changes Contributing to Right Ventricular Cardiomyocyte Diastolic Dysfunction in Pulmonary Arterial Hypertension, Journal of the American Heart Association, vol.3, 3, 2014,pp 1-11
2010Protein kinase C alpha and epsilon phosphorylation of troponin and myosin binding protein C reduce Ca(2+) sensitivity in human myocardiumdos Remedios, Cristobal; Boontje, Nicky M.; Jaquet, Kornelia; Kooij, Viola; Stienen, Ger J.M.; van der Velden, Jolanda; Zaremba, Ruud; School of Medical Sciences: Anatomy & HistologyProtein kinase C alpha and epsilon phosphorylation of troponin and myosin binding protein C reduce Ca(2+) sensitivity in human myocardium, Basic Research in Cardiology, vol.105, 2,pp 289-300
2011Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardiumdos Remedios, Cristobal; Boknik, Peter; Gergs, Ulrich; Kirchhefer, Uwe; Muller, Frank; Neumann, Joachim; Schmitz, Wilhelm; Sindermann, Jurgen; Stienen, Ger J.M.; van der Velden, Jolanda; Wijnker, Paul; School of Medical Sciences: Bosch InstituteProtein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium, Journal Of Muscle Research And Cell Motility, vol.32, 3, 2011,pp 221-233
2013Right Ventricular Diastolic Impairment in Patients With Pulmonary Arterial Hypertensiondos Remedios, Cristobal; Dorfmuller, Peter; et al, Various; Gan, Tji-Joong; Handoko, Louis; Marcus, Tim; Ottenheijm, Coen; Paulus, Walter; Rain, Silvia; Stienen, Ger J.M.; Trip, Pia; Westerhof, Nico; School of Medical Sciences: Bosch InstituteRight Ventricular Diastolic Impairment in Patients With Pulmonary Arterial Hypertension, Circulation, vol.128, 18, 2013,pp 2016-2025
2015Synergistic role of ADP and Ca2+ in diastolic myocardial stiffnessDos Remedios, Cristobal Guillermo; Bollen, Ilse A E; Fowler, Ewan D.; Helmes, Michiel; Kuster, Diederik; Mcconnell, Mark; Najafi, Aref; Sequeira, Vasco; Stienen, Ger J.M.; Tardiff, Jil; van der Velden, Jolanda; White, Ed; Wust, Rob C I; School of Medical Sciences: Bosch InstituteSynergistic role of ADP and Ca2+ in diastolic myocardial stiffness, The Journal of Physiology, vol.593, 17, 2015,pp 3899-3916
2013Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutationsClarke, Nigel; Beggs, Alan H.; Buck, Danielle; de Winter, Josine Marieke; Granzier, Henk; Hidalgo, Carlos; Jasper, Jeffrey; Lawlor, Michael; Malik, Fady; Ottenheijm, Coen; Stienen, Ger J.M.; Children's Hospital Westmead: Paediatrics & Child HealthTroponin activator augments muscle force in nemaline myopathy patients with nebulin mutations, Journal of Medical Genetics, vol.50, 6, 2013,pp 383-392