Browsing by Author Seebacher, Nicole

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Issue DateTitleAuthor(s)Citation
2015Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-Glycoprotein (Pgp)Arvind, Akanksha; Gutierrez, Elaine; Jansson, Patric; Maleki, Sanaz; Richardson, Desi (Des); Sahni, Sumit; Seebacher, Nicole; Sharp, Danae; Stacy, Alexandra Elizabeth; Yamagishi, Tetsuo; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; Northern Clinical School: Kolling Institute; School of Medical Sciences: Pathology; Medicine; Biological Sciences; Central Clinical School: Medicine; School of Medical Sciences: Pathology; School of Medical Sciences: School of Medical SciencesDi-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-Glycoprotein (Pgp), The Journal of Biological Chemistry, vol.290, 15, 2015,pp 9588-9603
2016Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug TransporterJansson, Patric; Lane, Darius John Rowland; Richardson, Desi (Des); Seebacher, Nicole; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Biological SciencesGlucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter, The Journal of Biological Chemistry, vol.291, 8, 2016,pp 3796-3820
2015Glucose modulation induces reactive oxygen species and increases P-glycoprotein-mediated multidrug resistance to chemotherapeuticsJansson, Patric; Richardson, Desi (Des); Seebacher, Nicole; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; Biological SciencesGlucose modulation induces reactive oxygen species and increases P-glycoprotein-mediated multidrug resistance to chemotherapeutics, British Journal of Pharmacology, vol.172, 10, 2015,pp 2557-2772
2016Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT)Arzuman, Laila; Gutierrez, Elaine; Jansson, Patric; Kalinowski, Danuta; Kovacevic, Zaklina; Lane, Darius John Rowland; Lok, Hiu; Merlot, Angelica; Richardson, Desi (Des); Richardson, Vera; Sahni, Sumit; Seebacher, Nicole; School of Medical Sciences: Biomedical Sciences; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Biomedical Sciences; School of Medical Sciences: Bosch Institute; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; Biological SciencesLysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT), BBA: Biochimica et Biophysica Acta - Molecular Cell Research, vol.1863, 7 Pt A, 2016,pp 1665-1681
2016A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpCJansson, Patric; Richardson, Desi (Des); Seebacher, Nicole; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Biological SciencesA mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC, Cell Death and Disease, vol.7, 12, 2016,pp 1-13
2015The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "Triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazonesFouani, Leyla; Jansson, Patric; Kalinowski, Danuta; Kovacevic, Zaklina; Lane, Darius John Rowland; Merlot, Angelica; Richardson, Desi (Des); Sahni, Sumit; Seebacher, Nicole; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Bosch Institute; School of Medical Sciences: Pathology; Medicine; Biological SciencesThe renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "Triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones, Pharmacological Research, vol.100, N/A, 2015,pp 255-260
2016Turning the gun on cancer: Utilizing lysosomal P-glycoprotein as a new strategy to overcome multi-drug resistanceJansson, Patric; Lane, Darius John Rowland; Richardson, Desi (Des); Seebacher, Nicole; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; Biological SciencesTurning the gun on cancer: Utilizing lysosomal P-glycoprotein as a new strategy to overcome multi-drug resistance, Free Radical Biology and Medicine, vol.96, N/A, 2016,pp 432-445