Browsing by Author Richardson, Desi (Des)

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Issue DateTitleAuthor(s)Citation
2014The Active Role of Vitamin C in Mammalian Iron Metabolism: Much More Than Just Enhanced Iron Absorption!Lane, Darius John Rowland; Richardson, Desi (Des); School of Medical Sciences: Pathology; School of Medical Sciences: PathologyThe Active Role of Vitamin C in Mammalian Iron Metabolism: Much More Than Just Enhanced Iron Absorption!, Free Radical Biology and Medicine, vol.75, C, 2014,pp 69-83
2015Adenosine Monophosphate-Activated Kinase and Its Key Role in Catabolism: Structure, Regulation, Biological Activity and Pharmacological ActivationKrishan, Sukriti; Richardson, Desi (Des); Sahni, Sumit; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; MedicineAdenosine Monophosphate-Activated Kinase and Its Key Role in Catabolism: Structure, Regulation, Biological Activity and Pharmacological Activation, Molecular Pharmacology, vol.87, 3, 2015,pp 363-377
2013Alkyl Substituted 2'-Benzoylpyridine Thiosemicarbazone Chelators with Potent and Selective Anti-Neoplastic Activity: Novel Ligands that Limit Methemoglobin FormationGutierrez, Elaine; Jansson, Jan (Patric); Kalinowski, Danuta; Richardson, Desi (Des); Stefani, Christian; Bernhardt, Paul V; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyAlkyl Substituted 2'-Benzoylpyridine Thiosemicarbazone Chelators with Potent and Selective Anti-Neoplastic Activity: Novel Ligands that Limit Methemoglobin Formation, Journal of Medicinal Chemistry, vol.56, 1, 2013,pp 357-370
2014AMP kinase (PRKAA1)Krishan, Sukriti; Richardson, Desi (Des); Sahni, Sumit; School of Medical Sciences: Bosch Institute; School of Medical Sciences: Pathology; MedicineAMP kinase (PRKAA1), Journal of Clinical Pathology, vol.67, 9, 2014,pp 758-763
2008Ancestral roles of eukaryotic frataxin: mitochondrial frataxin function and heterologous expression of hydrogenosomal Trichomonas homologues in trypanosomesRichardson, Desi (Des); Sutak, Robert; Ginger, Michael; Jirku, Milan; Long, Shaojun; Lukes, Julius; Mach, Jan; Tachezy, Jan; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyAncestral roles of eukaryotic frataxin: mitochondrial frataxin function and heterologous expression of hydrogenosomal Trichomonas homologues in trypanosomes, Molecular Microbiology, vol.69, 1, 2008,pp 94-109
2014The Anti-Cancer Agent, Dp44mT, Overcomes Pro-Survival Autophagy by Two Mechanisms: Persistent Induction of Autophagosome Synthesis and Impairment of Lysosomal IntegrityGutierrez, Elaine; Jansson, Patric; Richardson, Desi (Des); School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyThe Anti-Cancer Agent, Dp44mT, Overcomes Pro-Survival Autophagy by Two Mechanisms: Persistent Induction of Autophagosome Synthesis and Impairment of Lysosomal Integrity, The Journal of Biological Chemistry, vol.289, 48, 2014,pp 33568-33589
2013Anti-plasmodial activity of aroylhydrazone and thiosemicarbazone iron chelators: Effect on erythrocyte membrane integrity, parasite development and the intracellular labile iron poolKalinowski, Danuta; Lane, Darius; Lovejoy, David; Richardson, Desi (Des); Adenuga, Babafemi B; Kurantsin-Mills, Joseph; Kwagyan, John; Walcourt, Asikiya; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyAnti-plasmodial activity of aroylhydrazone and thiosemicarbazone iron chelators: Effect on erythrocyte membrane integrity, parasite development and the intracellular labile iron pool, Journal of Inorganic Biochemistry, vol.129, N/A, 2013,pp 43-51
2016The Anticancer Agent, Di-2-Pyridylketone 4,4-Dimethyl-3-Thiosemicarbazone (Dp44mT), Up-Regulates the AMPK-Dependent Energy Homeostasis Pathway in Cancer CellsKrishan, Sukriti; Richardson, Desi (Des); Sahni, Sumit; School of Medical Sciences: Bosch Institute; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyThe Anticancer Agent, Di-2-Pyridylketone 4,4-Dimethyl-3-Thiosemicarbazone (Dp44mT), Up-Regulates the AMPK-Dependent Energy Homeostasis Pathway in Cancer Cells, Biochimica et Biophysica Acta, vol.1863, 12, 2016,pp 2916-2933
2011Antitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in LysosomesBrunk, Ulf; Jansson, Patric; Lovejoy, David; Richardson, Desi (Des); Wong, Jacky; Ponka, Prem; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyAntitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in Lysosomes, Cancer Research, vol.71, 17, 2011,pp 5871-5880
2013Biochemistry of cardiomyopathy in the mitochondrial disease Friedreich's ataxiaHuang, Michael; Lane, Darius; Richardson, Desi (Des); Sivagurunathan, Sutharshani; Ting, Samantha; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Physiology; Central Clinical School: PathologyBiochemistry of cardiomyopathy in the mitochondrial disease Friedreich's ataxia, The Biochemical Journal, vol.453, 3, 2013,pp 321-336
2016Biphasic effects of l-ascorbate on the tumoricidal activity of non-thermal plasma against malignant mesothelioma cellsRichardson, Desi (Des); Toyokuni, Shinya; Hori, Masaru; Ito, Fumiya; Mizuno, Masaaki; Okazaki, Yasumasa; Shi, Lei; Tanaka, Hiromasa; Wang, Yue; School of Medical Sciences: Pathology; Northern Clinical School: PathologyBiphasic effects of l-ascorbate on the tumoricidal activity of non-thermal plasma against malignant mesothelioma cells, Archives of Biochemistry and Biophysics, vol.605, N/A, 2016,pp 109-116
2012Bp44mT: An Orally-Active Iron Chelator of the Thiosemicarbazone Class with Potent Anti-Tumour EfficacyRichardson, Desi (Des); Suryo Rahmanto, Yohan; Yu, Yu; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyBp44mT: An Orally-Active Iron Chelator of the Thiosemicarbazone Class with Potent Anti-Tumour Efficacy, British Journal of Pharmacology, vol.165, 1, 2012,pp 148-166
2015Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in diseaseBae, Dong-Hun; Huang, Michael; Jansson, Patric; Kalinowski, Danuta; Lane, Darius John Rowland; Merlot, Angelica; Richardson, Desi (Des); Sahni, Sumit; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Bosch Institute; School of Medical Sciences: Pathology; MedicineCellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease, Biochimica et Biophysica Acta. General Subjects, vol.1853, 5, 2015,pp 1130-1144
2013Cellular Uptake of the Antitumor Agent Dp44mT Occurs via a Carrier/Receptor-Mediated MechanismKalinowski, Danuta; Menezes, Sharleen; Merlot, Angelica; Pantarat, Namfon; Richardson, Desi (Des); Sahni, Sumit; School of Medical Sciences: Pathology; School of Medical Sciences: Bosch Institute; School of Medical Sciences: Bosch Institute; Western Clinical School: Westmead Millennium Institute; School of Medical Sciences: Pathology; MedicineCellular Uptake of the Antitumor Agent Dp44mT Occurs via a Carrier/Receptor-Mediated Mechanism, Molecular Pharmacology, vol.84, 6, 2013,pp 911-924
2010Comparison of Clinically Used and Experimental Iron Chelators for Protection against Oxidative Stress-Induced Cellular InjuryKalinowski, Danuta; Richardson, Desi (Des); Bendova, Petra; Haskova, Pavlina; Jirkovsky, Eduard; Kovarikova, Petra; Mackova, Eliska; Popelova, Olga; Simunek, Tomas; Sterba, Martin; Vavrova, Anna; Vavrova, Katerina; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyComparison of Clinically Used and Experimental Iron Chelators for Protection against Oxidative Stress-Induced Cellular Injury, Chemical Research in Toxicology, vol.23, 6, 2010,pp 1105-1114
2013Cytosolic phospholipase A2alpha sustains pAKT, pERK and AR levels in PTEN-null/mutated prostate cancer cellsAssinder, Stephen; Dong, Qihan; Gong, Zhen; Hua, Sheng; Niknami, Marzieh; Richardson, Desi (Des); Teng, Ying; Vignarajan, Soma; Witting, Paul; Yao, Mu; Hejazi, Leila; School of Medical Sciences: Physiology; Central Clinical School: Medicine; School of Medical Sciences: Bosch Institute; School of Medical Sciences: Bosch Institute; Central Clinical School: Medicine; School of Medical Sciences: Pathology; Anaesthesia; Central Clinical School: Medicine; School of Medical Sciences: Pathology; Central Clinical School: MedicineCytosolic phospholipase A2alpha sustains pAKT, pERK and AR levels in PTEN-null/mutated prostate cancer cells, Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol.1831, 6, 2013,pp 1146-1157
2013Deferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivoJansson, Jan (Patric); Kalinowski, Danuta; Lovejoy, David; Lui, Goldie; Obeidy, Peyman; Richardson, Desi (Des); Alderson, D; Bedford, M; Chadwick, C; Ford, Samuel; Iqbal, TH; Nichols, L; Tselepis, Chris; Tucker, O; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Bosch Institute; Central Clinical School: Pathology; School of Medical Sciences: PathologyDeferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivo, British Journal of Pharmacology, vol.168, 6, 2013,pp 1316-1328
2015Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-Glycoprotein (Pgp)Arvind, Akanksha; Gutierrez, Elaine; Jansson, Patric; Maleki, Sanaz; Richardson, Desi (Des); Sahni, Sumit; Seebacher, Nicole; Sharp, Danae; Stacy, Alexandra Elizabeth; Yamagishi, Tetsuo; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; Northern Clinical School: Kolling Institute; School of Medical Sciences: Pathology; Medicine; Biological Sciences; Central Clinical School: Medicine; School of Medical Sciences: Pathology; School of Medical Sciences: School of Medical SciencesDi-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-Glycoprotein (Pgp), The Journal of Biological Chemistry, vol.290, 15, 2015,pp 9588-9603
2015Differential targeting of the cyclin-dependent kinase inhibitor by chelators with anti-proliferative activity in a range of tumor cell-typesKovacevic, Zaklina; Richardson, Desi (Des); Saleh Moussa, Rayan; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyDifferential targeting of the cyclin-dependent kinase inhibitor by chelators with anti-proliferative activity in a range of tumor cell-types, Oncotarget, vol.6, 30, 2015,pp 29694-29711
2013Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cellsAssinder, Stephen; Chen, Zhongyan; Dixon, Katie; Dong, Qihan; Kovacevic, Zaklina; Lui, Goldie; Richardson, Desi (Des); Yao, Mu; Zhang, Daohai; School of Medical Sciences: Physiology; School of Medical Sciences: Bosch Institute; School of Medical Sciences: Pathology; Central Clinical School: Medicine; School of Medical Sciences: Pathology; School of Medical Sciences: Bosch Institute; School of Medical Sciences: Pathology; Central Clinical School: Medicine; School of Medical Sciences: PathologyDp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells, British Journal of Cancer, vol.108, 2, 2013,pp 409-419