Browsing by Author Melrose, James

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Issue DateTitleAuthor(s)Citation
2016Ablation of Perlecan domain I heparan sulfate reduces progressive cartilage degradation, synovitis, and osteophyte size in post-traumatic osteoarthritisJackson, Miriam; Little, Christopher; Melrose, James; Shu, Cindy; Smith, Margaret; Smith, Susan; Lord, Megan; Penm, Steven; Whitelock, John M.; Northern Clinical School: Kolling Institute; Northern Clinical School: Kolling Institute; Northern Clinical School: Surgery; Northern Clinical School: Inst. for Bone & Joint Research; Northern Clinical School: Inst. for Bone & Joint Research; Northern Clinical School: Inst. for Bone & Joint ResearchAblation of Perlecan domain I heparan sulfate reduces progressive cartilage degradation, synovitis, and osteophyte size in post-traumatic osteoarthritis, Arthritis & Rheumatology, vol.68, 4, 2016,pp 868-879
2007Aggrecan, versican and type VI collagen are components of annular translamellar crossbridges in the intervertebral discAppleyard, Richard; Little, Christopher; Melrose, James; Smith, Susan; Medicine; Northern Clinical School: Surgery; Northern Clinical School: Surgery; Northern Clinical School: Inst. for Bone & Joint ResearchAggrecan, versican and type VI collagen are components of annular translamellar crossbridges in the intervertebral disc, European Spine Journal, vol.Published online: 31 October 2007,(N/A),2007,pp N/A-N/A
2013Altered stress induced by partial transection of the infraspinatus tendon leads to perlecan (HSPG2) accumulation in an ovine model of tendinopathyDart, Andrew; Little, Christopher; Melrose, James; Ravi, Varshini; Smith, Margaret; Smith, Susan; Sonnabend, David; Young, A; Vet Science Faculty; Northern Clinical School: Kolling Institute; Northern Clinical School: Surgery; Northern Clinical School: Kolling Institute; Northern Clinical School: Inst. for Bone & Joint Research; Northern Clinical School: Inst. for Bone & Joint Research; Northern Clinical School: SurgeryAltered stress induced by partial transection of the infraspinatus tendon leads to perlecan (HSPG2) accumulation in an ovine model of tendinopathy, Tissue and Cell, vol.45, 1, 2013,pp 77-82
2007Are animal models useful for studying human disc disorders/degeneration?Little, Christopher; Melrose, James; Alini, Mauro; Eisenstein, Stephen M; Ito, Keito; Kettler, A; Masuda, Koichi; Ralphs, Jim; Stokes, Ian; Wilke, Hans Joachim; Northern Clinical School: Surgery; Northern Clinical School: SurgeryAre animal models useful for studying human disc disorders/degeneration?, European Spine Journal, vol.Published online: 14 July 2007,(0),2007,pp 0-N/A
2003Assessment of the cellular heterogeneity of the ovine intervertebral disc: comparison with synovial fibroblasts and articular chondrocytesGhosh, Peter; Melrose, James; Smith, Susan; Northern Clinical School: Surgery; Northern Clinical School: Surgery; Northern Clinical School: Inst. for Bone & Joint ResearchAssessment of the cellular heterogeneity of the ovine intervertebral disc: comparison with synovial fibroblasts and articular chondrocytes, European Spine Journal, vol.12,(1),2003,pp 57-65
2007Biglycan and fibromodulin fragmentation correlates with temporal and spatial annular remodelling in experimentally injured ovine intervertebral discsDart, Andrew; Fuller, Emily; Little, Christopher; Melrose, James; Smith, Susan; Young, Allan; Roughley, Peter J; Vet Science Faculty; Northern Clinical School: Inst. for Bone & Joint Research; Northern Clinical School: Surgery; Northern Clinical School: Surgery; Northern Clinical School: Inst. for Bone & Joint Research; Northern Clinical School: MedicineBiglycan and fibromodulin fragmentation correlates with temporal and spatial annular remodelling in experimentally injured ovine intervertebral discs, European Spine Journal, vol.16,(12),2007,pp 2193-2205
2009Calcification in the ovine intervertebral disc: a model of hydroxyapatite deposition diseaseBurkhardt, Daniel; Little, Christopher; Melrose, James; Taylor, Thomas; Cake, Martin A.; Dillon, Carolyn T.; Read, Richard A; Northern Clinical School: Surgery; Northern Clinical School: Kolling Institute; Northern Clinical School: Surgery; Northern Clinical School: SurgeryCalcification in the ovine intervertebral disc: a model of hydroxyapatite deposition disease, European Spine Journal, vol.18,(4),2009,pp 479-489
2014Can Proinflammatory Cytokine Gene Expression Explain Multifidus Muscle Fiber Changes After an Intervertebral Disc Lesion?Little, Christopher; Melrose, James; Shu, Cindy; Blomster, Linda; Hall, Leanne; Hodges, Paul; James, Gregory; Schmid, Annina; Northern Clinical School: Kolling Institute; Northern Clinical School: Surgery; Northern Clinical School: Inst. for Bone & Joint ResearchCan Proinflammatory Cytokine Gene Expression Explain Multifidus Muscle Fiber Changes After an Intervertebral Disc Lesion?, Spine, vol.39, 13, 2014,pp 1010-1017
2015Can We Produce Heparin/Heparan Sulfate Biomimetics Using “Mother-Nature” as the Gold Standard?Melrose, James; Farrugia, B; Lord, Megan; Whitelock, John; Northern Clinical School: SurgeryCan We Produce Heparin/Heparan Sulfate Biomimetics Using “Mother-Nature” as the Gold Standard?, Molecules, vol.20, 3, 2015,pp 4254-4276
2012The cartilage matrix molecule components produced by human foetal cartilage rudiment cells within scaffolds and the role of exogenous growth factorsMelrose, James; Chuang, Christine; Doran, Pauline; Lord, Megan; Shahin, Kifah; Whitelock, John; Northern Clinical School: SurgeryThe cartilage matrix molecule components produced by human foetal cartilage rudiment cells within scaffolds and the role of exogenous growth factors, Biomaterials, vol.33, 16, 2012,pp 4078-4088
2012Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint developmentLittle, Christopher; Melrose, James; Smith, Susan; Caterson, Bruce; Hayes, Anthony; Hughes, Clare E.; Isaacs, Marc; Northern Clinical School: Kolling Institute; Northern Clinical School: Surgery; Northern Clinical School: Inst. for Bone & Joint ResearchChondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development, Histochemistry and Cell Biology, vol.138, 3, 2012,pp 461-475
2011Colocalization in vivo and association in vitro of perlecan and elastinMelrose, James; Smith, Margaret; Smith, Susan; Weiss, Anthony; Hayes, Anthony; Lord, Megan; Whitelock, John M.; Northern Clinical School: Surgery; Northern Clinical School: Inst. for Bone & Joint Research; Northern Clinical School: Inst. for Bone & Joint Research; Molecular BioscienceColocalization in vivo and association in vitro of perlecan and elastin, Histochemistry and Cell Biology, vol.136, N/A, 2011,pp 437-454
2012A comparative evaluation of the small leucine-rich proteoglycans of pathological human intervertebral discsMelrose, James; Brown, Sharon; Caterson, Bruce; Eisenstein, Stephen M; Roberts, Sally; Roughley, Peter; Northern Clinical School: SurgeryA comparative evaluation of the small leucine-rich proteoglycans of pathological human intervertebral discs, European Spine Journal, vol.21, Suppl 2, 2012,pp S154-S159
2013Comparative immunolocalisation of fibrillin-1 and perlecan in the human foetal, and HS-deficient hspg2 exon 3 null mutant mouse intervertebral discMelrose, James; Smith, Susan; Hayes, Anthony; Northern Clinical School: Surgery; Northern Clinical School: Inst. for Bone & Joint ResearchComparative immunolocalisation of fibrillin-1 and perlecan in the human foetal, and HS-deficient hspg2 exon 3 null mutant mouse intervertebral disc, Histochemistry and Cell Biology, vol.139, 1, 2013,pp 1-11
2010Comparative immunolocalisation of perlecan with collagen II and aggrecan in human foetal, newborn and adult ovine joint tissues demonstrates perlecan as an early developmental chondrogenic markerMelrose, James; Shu, Cindy; Smith, Susan; Northern Clinical School: SurgeryComparative immunolocalisation of perlecan with collagen II and aggrecan in human foetal, newborn and adult ovine joint tissues demonstrates perlecan as an early developmental chondrogenic marker, Histochemistry and Cell Biology, vol.134, 3,pp 251-263
2013Comparative immunolocalisation of perlecan, heparan sulphate, fibroblast growth factor-18, and fibroblast growth factor receptor-3 and their prospective roles in chondrogenic and osteogenic development of the human foetal spineLittle, Christopher; Melrose, James; Shu, Cindy; Smith, Susan; Northern Clinical School: Kolling Institute; Northern Clinical School: Surgery; Northern Clinical School: Inst. for Bone & Joint Research; Northern Clinical School: Inst. for Bone & Joint ResearchComparative immunolocalisation of perlecan, heparan sulphate, fibroblast growth factor-18, and fibroblast growth factor receptor-3 and their prospective roles in chondrogenic and osteogenic development of the human foetal spine, European Spine Journal, vol.22, 8, 2013,pp 1774-1784
2011Comparative immunolocalisation of the elastin fibre associated proteins fibrillin-1, LTBP2 and MAGP-1 with components of the collagenous and proteoglycan matrix of the foetal human Intervertebral DiscMelrose, James; Smith, Sue; Gibson, M; Hayes, Anthony; Northern Clinical School: Surgery; Northern Clinical School: General PracticeComparative immunolocalisation of the elastin fibre associated proteins fibrillin-1, LTBP2 and MAGP-1 with components of the collagenous and proteoglycan matrix of the foetal human Intervertebral Disc, Spine, vol.36, 21, 2011,pp E1365-1372
2014Confocal microscopy demonstrates association of LTBP-2 in fibrillin-1 microfibrils and colocalisation with perlecan in the disc cell pericellular matrixMelrose, James; Shu, Cindy; Gibson, Mark; Hayes, Anthony; Northern Clinical School: Surgery; Northern Clinical School: Inst. for Bone & Joint ResearchConfocal microscopy demonstrates association of LTBP-2 in fibrillin-1 microfibrils and colocalisation with perlecan in the disc cell pericellular matrix, Tissue and Cell, vol.46, 3, 2014,pp 185-197
2016The CS Sulphation Motifs 4C3, 7D4, 3B3[-]; and Perlecan Identify Stem Cell Populations and Niches, Activated Progenitor Cells and Transitional Tissue Development in the Fetal Human ElbowLittle, Christopher; Melrose, James; Smith, Susan; Caterson, Bruce; Hayes, Anthony; Hughes, Clare E.; Northern Clinical School: Kolling Institute; Northern Clinical School: Surgery; Northern Clinical School: Inst. for Bone & Joint ResearchThe CS Sulphation Motifs 4C3, 7D4, 3B3[-]; and Perlecan Identify Stem Cell Populations and Niches, Activated Progenitor Cells and Transitional Tissue Development in the Fetal Human Elbow, Stem Cells and Development, vol.25, 11, 2016,pp 836-847
2010A Detailed Microscopic Examination of Alterations in Normal Anular Structure Induced by Mechanical Destabilization in an Ovine Model of Disc DegenerationAppleyard, Richard; Little, Christopher; Melrose, James; Schollum, Meredith; Northern Clinical School: Surgery; Northern Clinical School: Kolling Institute; Northern Clinical School: SurgeryA Detailed Microscopic Examination of Alterations in Normal Anular Structure Induced by Mechanical Destabilization in an Ovine Model of Disc Degeneration, Spine, vol.35, 22,pp 1965-1973