Browsing by Author McArthur, Grant A.

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Issue DateTitleAuthor(s)Citation
2014Activity of trametinib in K601E and L597Q BRAF mutation-positive metastatic melanomaLong, Georgina; Bowyer, Samantha; Hicks, Rodney J; Lyle, Megan; McArthur, Grant A.; Millward, Michael; Raleigh, Jeanette; Rao, Aparna; Sandhu, Shahneen; Central Clinical School: The Sydney Cancer CentreActivity of trametinib in K601E and L597Q BRAF mutation-positive metastatic melanoma, Melanoma Research, vol.24, 5, 2014,pp 504-508
2012Atypical Melanocytic Proliferations and New Primary Melanomas in Patients With Advanced Melanoma Undergoing Selective BRAF InhibitionLong, Georgina; Busam, Klaus; Carvajal, Richard; Dummer, R; Egberts, Friederike; Goldinger, Simone; Hauschild, A; Hillen, Uwe; Kashani-Sabet, Mohammed; Lacouture, Mario; Livingstone, Elisabeth; McArthur, Grant A.; Schadendorf, Dirk; Scherag, Andre; Sucker, Antje; Zimmer, Lisa; Central Clinical School: The Sydney Cancer CentreAtypical Melanocytic Proliferations and New Primary Melanomas in Patients With Advanced Melanoma Undergoing Selective BRAF Inhibition, Journal of Clinical Oncology, vol.30, 19, 2012,pp 2375-2383
2013BRAF/NRAS Wild-Type Melanomas Have a High Mutation Load Correlating with Histologic and Molecular Signatures of UV DamageKakavand, Hojabr; Mann, Graham; Scolyer, Richard; Thompson, John; Behren, Andreas; Cebon, Jonathan Simon; Dobrovic, Alexander; Kelly, John; Li, Jason; Mar, Victoria; McArthur, Grant A.; McLean, Catriona; Papenfuss, Anthony Troy; Tothill, Richard W.; Wolfe, Rory; Wong, Stephen; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Western Clinical School: Westmead Millennium Institute; Central Clinical School: Pathology; Central Clinical School: SurgeryBRAF/NRAS Wild-Type Melanomas Have a High Mutation Load Correlating with Histologic and Molecular Signatures of UV Damage, Clinical Cancer Research, vol.19, 17, 2013,pp 4589-4598
2013CDC25B Overexpression Stabilises Centrin 2 and Promotes the Formation of Excess Centriolar FociChircop (nee Fabbro), Megan; Astuti, Puji; Boutros, Rose; Ducommun, Bernard; Gabrielli, B; Lorenzo, Corinne; McArthur, Grant A.; Mondesert, Odile; Children's Hospital Westmead: Childrens Medical Research InsCDC25B Overexpression Stabilises Centrin 2 and Promotes the Formation of Excess Centriolar Foci, PLoS One, vol.8, 7, 2013,pp 1-13
2010Clinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KITHamilton, Anne; Dobrovic, Alexander; Handolias, D; Kerr, L; McArthur, Grant A.; Moodie, K; Salemi, R; Tan, A; Central Clinical School: MedicineClinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KIT, British Journal of Cancer, vol.102, 8,pp 1219-1223
2015Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signalingDe Paoli-Iseppi, Ricardo; Gallagher, Stuart; Gowrishankar, Kavitha; Gunatilake, Dilini; Heinemann, Anja; Hersey, Peter; Madore, Jason; Strbenac, Dario; Tiffen, Jessamy; Wilmott, James; Yang, Jean Yee Hwa; Cullinane, Carleen; McArthur, Grant A.; Prinjha, Rab; Smithers, Nicholas; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Western Clinical School: Medicine (Westmead); Western Clinical School: Medicine (Westmead); Northern Clinical School: Kolling Institute; Northern Clinical School: Kolling Institute; Northern Clinical School: Surgery; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Mathematics & Statistics; Central Clinical School: Centenary Institute; Central Clinical School: Surgery; Mathematics & StatisticsCombining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling, Oncotarget, vol.6, 25, 2015,pp 21507-21521
2014Control of NF-kB activity in human melanoma by bromodomain and extra-terminal protein inhibitor I-BET151Gallagher, Stuart; Gowrishankar, Kavitha; Gunatilake, Dilini; Hersey, Peter; Jin, Lei; Mijatov, Branka; Pupo, Gulietta; Rizos, Helen; Tiffen, Jessamy; Cullinane, Carleen; James, Wilmott; McArthur, Grant A.; Tummino, Peter J; Western Clinical School: Medicine (Westmead); Western Clinical School: Medicine (Westmead); Northern Clinical School: Kolling Institute; Northern Clinical School: Surgery; Northern Clinical School: Kolling Institute; Western Clinical School: Westmead Millennium Institute; Western Clinical School: Medicine (Westmead); Western Clinical School: Westmead Millennium Institute; Central Clinical School: Centenary InstituteControl of NF-kB activity in human melanoma by bromodomain and extra-terminal protein inhibitor I-BET151, Pigment Cell & Melanoma Research, vol.27, 6, 2014,pp 1126-1137
2016Efficacy and toxicity of treatment with the anti-CTLA-4 antibody ipilimumab in patients with metastatic melanoma after prior anti-PD-1 therapyCarlino, Matteo; Long, Georgina; Atkinson, Victoria; Bowyer, Samantha; et al, .; Khou, M.; Larkin, James; Lorigan, Paul; McArthur, Grant A.; Millward, Michael; Prithviraj, P.; Western Clinical School: Medicine (Westmead); Central Clinical School: The Sydney Cancer CentreEfficacy and toxicity of treatment with the anti-CTLA-4 antibody ipilimumab in patients with metastatic melanoma after prior anti-PD-1 therapy, British Journal of Cancer, vol.114, 10, 2016,pp 1084-1089
2017Efficacy of anti-PD-1 therapy in patients with melanoma brain metastasesCarlino, Matteo; Drummond, Martin; Guminski, Alexander; Kefford, Richard (Rick); Lo, Serigne; Long, Georgina; Menzies, Alexander Maxwel; Park, John; Rai, Rajat; Andrews, Miles C; Cebon, Jonathan Simon; Haydon, Andrew; Klein, O; McArthur, Grant A.; Mendis, S; Parakh, S; Rowe, Catherine; Wong, Annie; Xu, Wen; Western Clinical School: Medicine (Westmead); School of Public Health: Public Health; Northern Clinical School: Medicine; Western Clinical School: Medicine (Westmead); The George Institute for Global Health; Northern Clinical School: Medicine; Northern Clinical School: Medicine; Central Clinical School: Medicine; Central Clinical School: MedicineEfficacy of anti-PD-1 therapy in patients with melanoma brain metastases, British Journal of Cancer, vol.116, 12, 2017,pp 1558-1563
2014The Epigenetic Regulator I-BET151 Induces BIM Dependent Apoptosis and Cell Cycle Arrest OF Human Melanoma CellsGallagher, Stuart; Gowrishankar, Kavitha; Gunatilake, Dilini; Hersey, Peter; Jin, Lei; Mijatov, Branka; Pupo, Gulietta; Rizos, Helen; Tiffen, Jessamy; Cullinane, Carleen; McArthur, Grant A.; Prinjha, Rab; Smithers, Nicholas; Western Clinical School: Medicine (Westmead); Western Clinical School: Medicine (Westmead); Northern Clinical School: Kolling Institute; Northern Clinical School: Surgery; Northern Clinical School: Kolling Institute; Western Clinical School: Westmead Millennium Institute; Western Clinical School: Medicine (Westmead); Western Clinical School: Westmead Millennium Institute; Central Clinical School: Centenary InstituteThe Epigenetic Regulator I-BET151 Induces BIM Dependent Apoptosis and Cell Cycle Arrest OF Human Melanoma Cells, Journal of Investigative Dermatology, vol.134, 11, 2014,pp 1523-1747
2015The genomic landscape of phaeochromocytomaBenn, Diana; Clifton-Bligh, Roderick; Gill, Anthony; Robinson, Bruce; Flynn, Aidan; Fox, Stephen B.; George, Joshy; Hicks, Rodney J.; Hogg, Annette; James, Paul; Li, Jason; McArthur, Grant A.; Tothill, Richard W.; Trainer, Alison; Waldeck, Kelly; Northern Clinical School: Kolling Institute; Northern Clinical School: Medicine; Northern Clinical School: Pathology; Northern Clinical School: MedicineThe genomic landscape of phaeochromocytoma, Journal of Pathology, vol.236, 1, 2015,pp 78-89
2017Melanoma staging: Evidence-based changes in the American Joint Committee on Cancer eighth edition cancer staging manualLong, Georgina; Scolyer, Richard; Thompson, John; et al, Various; Faries, Mark; Gershenwald, Jeffrey E.; Haydu, Lauren E.; Hess, Kenneth R; Kirkwood, John M; Lazar, Alexander J.; McArthur, Grant A.; Ross, Merrick I; Sondak, Vernon; Northern Clinical School: Medicine; Central Clinical School: Pathology; Central Clinical School: SurgeryMelanoma staging: Evidence-based changes in the American Joint Committee on Cancer eighth edition cancer staging manual, CA A Cancer Journal for Clinicians, vol.67, 6, 2017,pp 472-492
2009O6-methylguanine-DNA methyltransferase depletion and DNA damage in patients with melanoma treated with temozolomide alone or with lomeguatribKefford, Richard (Rick); Beith, Jane M.; Davis, I; Haydon, Andrew; Hersey, Peter; McArthur, Grant A.; McGown, G; Middleton, M. R.; Ranson, M; Thomson, Damien; Thorncraft, M; Watson, A. J.; Western Clinical School: Westmead Millennium InstituteO6-methylguanine-DNA methyltransferase depletion and DNA damage in patients with melanoma treated with temozolomide alone or with lomeguatrib, British Journal of Cancer, vol.100, 8,pp 1250-1256
2013Pharmacodynamic Effects and Mechanisms of Resistance to Vemurafenib in Patients With Metastatic MelanomaHersey, Peter; Long, Georgina; et al, Various; Flaherty, Keith; Gonzalez, Rene; Hutson, Thomas; Kim, Kevin; McArthur, Grant A.; Moschos, Stergios; Pavlick, Anna C.; Schuchter, Lynn; Trunzer, Kerstin; Weber, Jeffrey; Northern Clinical School: Surgery; Central Clinical School: The Sydney Cancer CentrePharmacodynamic Effects and Mechanisms of Resistance to Vemurafenib in Patients With Metastatic Melanoma, Journal of Clinical Oncology, vol.31, 14, 2013,pp 1767-1774
2017Phase I dose-escalation and -expansion study of the BRAF inhibitor encorafenib (LGX818) in metastatic BRAF-mutant melanomaCarlino, Matteo; Kefford, Richard (Rick); Arance, Ana; Delord, Jean-Pierre; et al, Various; Kudchakar, Ragini; Mahipal, Amit; McArthur, Grant A.; Nyakas, Marta; Robert, Caroline; Sullivan, Ryan; Yamada, Yasuhide; Westmead Clinical School: Medicine; Westmead Clinical School: MedicinePhase I dose-escalation and -expansion study of the BRAF inhibitor encorafenib (LGX818) in metastatic BRAF-mutant melanoma, Clinical Cancer Research, vol.23, 18, 2017,pp 5339-5348
2013Phase II Study of the MEK1/MEK2 Inhibitor Trametinib in Patients With Metastatic BRAF-Mutant Cutaneous Melanoma Previously Treated With or Without a BRAF InhibitorKefford, Richard (Rick); Long, Georgina; et al, Various; Fecher, Leslie A.; Gonzalez, Rene; Hwu, Patrick; Infante, Jeffrey; Kim, Kevin; McArthur, Grant A.; Millward, Michael; Pavlick, Anna C.; Ribas, Antoni; Sosman, Jeffrey; Western Clinical School: Westmead Millennium Institute; Central Clinical School: The Sydney Cancer CentrePhase II Study of the MEK1/MEK2 Inhibitor Trametinib in Patients With Metastatic BRAF-Mutant Cutaneous Melanoma Previously Treated With or Without a BRAF Inhibitor, Journal of Clinical Oncology, vol.31, 4, 2013,pp 482-489
2007Randomised trial of the combination of lomeguatrib and temozolomide and temozolomide alone in chemotherapy-naïve patients with metastatic cutaneous melanomaKefford, Richard (Rick); Beith, Jane M.; Davis, Ian D.; et, al; Harris, Peter; Haydon, Andrew; Hersey, Peter; McArthur, Grant A.; Mortimer, Peter; Ranson, Marie; Thompson, Damien; Western Clinical School: Westmead Millennium InstituteRandomised trial of the combination of lomeguatrib and temozolomide and temozolomide alone in chemotherapy-naïve patients with metastatic cutaneous melanoma, JOURNAL OF CLINICAL ONCOLOGY 2005, vol.25,(18),2007,pp 2540-2545
2006Rate of growth in melanomas: characteristics and associations of rapidly growing melanomas.Thompson, John; Dowling, John P.; Kelly, John W.; Liu, Wendy; McArthur, Grant A.; Murray, William K.; Wolfe, Rory; Central Clinical School: SurgeryRate of growth in melanomas: characteristics and associations of rapidly growing melanomas., Archives of dermatology, vol.142,(12),2006,pp 1551-1558
2014Surrogate endpoints for overall survival in metastatic melanoma: A meta-analysis of randomised controlled trialsKefford, Richard (Rick); Long, Georgina; Ascierto, Paolo; Dummer, R; Eggermont, Alexander; Flaherty, Keith; Hauschild, A; Hennig, Michael; Kirkwood, John; Lee, Sandra J; Lorigan, Paul; Mackensen, Andreas; McArthur, Grant A.; O'Day, Steven; Patel, Poulam; Robert, Caroline; Schadendorf, D; Western Clinical School: Westmead Millennium Institute; Central Clinical School: The Sydney Cancer CentreSurrogate endpoints for overall survival in metastatic melanoma: A meta-analysis of randomised controlled trials, The Lancet Oncology, vol.15, 3, 2014,pp 297-304
2012Survival in BRAF V600-mutant advanced melanoma treated with vemurafenibHersey, Peter; Kefford, Richard (Rick); et al, Various; Flaherty, Keith; Gonzalez, Rene; Hutson, Thomas; Kim, Kevin; McArthur, Grant A.; Moschos, Stergios; Pavlick, Anna C.; Schuchter, Lynn; Sosman, Jeffrey; Weber, Jeffrey; Northern Clinical School: Surgery; Western Clinical School: Westmead Millennium InstituteSurvival in BRAF V600-mutant advanced melanoma treated with vemurafenib, New England Journal of Medicine, vol.366, 8, 2012,pp 707-714