Browsing by Author Lovejoy, David

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Issue DateTitleAuthor(s)Citation
20092-Acetylpyridine Thiosemicarbazones are Potent Iron Chelators and Antiproliferative Agents: Redox Activity, Iron Complexation and Characterization of their Antitumor ActivityKalinowski, Danuta; Lovejoy, David; Richardson, Desi; Richardson, Vera; Bernhardt, Paul V.; Islam, Mohammad; Sharpe, Philip C.; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Bosch Institute2-Acetylpyridine Thiosemicarbazones are Potent Iron Chelators and Antiproliferative Agents: Redox Activity, Iron Complexation and Characterization of their Antitumor Activity, Journal of Medicinal Chemistry, vol.52,(5),2009,pp 1459-1470
2010Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agentsKalinowski, Danuta; Lovejoy, David; Richardson, Desi; Miao, Qinghua; Nie, Guangjun; Wang, Tiewei; Wang, Zhi; Wu, Yan; Xu, Dongxue; Xu, Li; Zhao, Yuliang; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyAmphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agents, Biomaterials, vol.31, 28,pp 7364-7375
2013Anti-plasmodial activity of aroylhydrazone and thiosemicarbazone iron chelators: Effect on erythrocyte membrane integrity, parasite development and the intracellular labile iron poolKalinowski, Danuta; Lane, Darius; Lovejoy, David; Richardson, Desi (Des); Adenuga, Babafemi B; Kurantsin-Mills, Joseph; Kwagyan, John; Walcourt, Asikiya; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyAnti-plasmodial activity of aroylhydrazone and thiosemicarbazone iron chelators: Effect on erythrocyte membrane integrity, parasite development and the intracellular labile iron pool, Journal of Inorganic Biochemistry, vol.129, N/A, 2013,pp 43-51
2011Antitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in LysosomesBrunk, Ulf; Jansson, Patric; Lovejoy, David; Richardson, Desi (Des); Wong, Jacky; Ponka, Prem; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyAntitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in Lysosomes, Cancer Research, vol.71, 17, 2011,pp 5871-5880
2009ATP7A is a novel target of retinoic acid receptor β2 in neuroblastoma cellsLovejoy, David; Richardson, Desi; Bell, Jessica; Bohlken, Andrew; Cheung, Belamy B.; Koach, J; Norris, Murray D.; Sekyere, Eric O.; Smith, Stewart; Thomas, Wayne D; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyATP7A is a novel target of retinoic acid receptor β2 in neuroblastoma cells, British Journal of Cancer, vol.100, 1,pp 96-105
2009Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agentsJansson, Jan; Kalinowski, Danuta; Lau, S; Lovejoy, David; Richardson, Desi; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Bosch Institute; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyCancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents, B B A - Bioenergetics, vol.1790,(7),2009,pp 702-717
2006Chelators at the cancer coalface: desferrioxamine to triapine and beyond.Kalinowski, Danuta; Lovejoy, David; Richardson, Desi; Wong, Jacky; Yu, Yu; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyChelators at the cancer coalface: desferrioxamine to triapine and beyond., Clinical Cancer Research, vol.12,(23),2006,pp 6876-6883
2013Deferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivoJansson, Jan (Patric); Kalinowski, Danuta; Lovejoy, David; Lui, Goldie; Obeidy, Peyman; Richardson, Desi (Des); Alderson, D; Bedford, M; Chadwick, C; Ford, Samuel; Iqbal, TH; Nichols, L; Tselepis, Chris; Tucker, O; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Bosch Institute; Central Clinical School: Pathology; School of Medical Sciences: PathologyDeferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivo, British Journal of Pharmacology, vol.168, 6, 2013,pp 1316-1328
2007Design, Synthesis, and Characterization of Novel Iron Chelators: Structure-Activity Relationships of the 2-Benzoylpyridine Thiosemicarbazone Series and Their 3-Nitrobenzoyl Analogues as Potent Antitumor AgentsKalinowski, Danuta; Lovejoy, David; Richardson, Desi; Yu, Yu; Bernhardt, Paul V; Islam, Mohammad; Kumar, Naresh; Liao, Yi-Tyng; Sharpe, Philip C; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyDesign, Synthesis, and Characterization of Novel Iron Chelators: Structure-Activity Relationships of the 2-Benzoylpyridine Thiosemicarbazone Series and Their 3-Nitrobenzoyl Analogues as Potent Antitumor Agents, Journal of Medicinal Chemistry, vol.50,(15),2007,pp 3716-3729
2006Dipyridyl Thiosemicarbazone Chelators with Potent and Selective Antitumor Activity Form Iron Complexes with Redox Activity.Kalinowski, Danuta; Lovejoy, David; Richardson, Desi; Bernhardt, Paul V.; Islam, Mohammad; Senaratne, Dakshita; Sharpe, Philip C.; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyDipyridyl Thiosemicarbazone Chelators with Potent and Selective Antitumor Activity Form Iron Complexes with Redox Activity., Journal of Medicinal Chemistry, vol.49,(22),2006,pp 6510-6521
2011Halogenated 2'-Benzoylpyridine Thiosemicarbazone (XBpT) Chelators with Potent and Selective Anti-Neoplastic Activity: Relationship to Intracellular Redox Activity.Jansson, Jan; Kalinowski, Danuta; Lovejoy, David; Punnia-Moorthy, Armugan; Richardson, Desi; Stefani, Christian; Bernhardt, Paul V.; Sharpe, Philip C.; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; Dentistry Faculty; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyHalogenated 2'-Benzoylpyridine Thiosemicarbazone (XBpT) Chelators with Potent and Selective Anti-Neoplastic Activity: Relationship to Intracellular Redox Activity., Journal of Medicinal Chemistry, vol.54, 19, 2011,pp 6936-6948
2009HPLC methods for determination of two novel thiosemicarbazone anti-cancer drugs (N4mT and Dp44mT) in plasma and their application to in vitro plasma stability of these agentsKalinowski, Danuta; Lovejoy, David; Richardson, Desi; Klimes, Jiri; Kovarikova, Petra; Stariat, Jan; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyHPLC methods for determination of two novel thiosemicarbazone anti-cancer drugs (N4mT and Dp44mT) in plasma and their application to in vitro plasma stability of these agents, Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, vol.877,(3),2009,pp 316-322
2011Iron Chelators of the Di-2-pyridylketone Thiosemicarbazone and 2-Benzoylpyridine Thiosemicarbazone Series Inhibit HIV-1 Transcription: Identification of Novel Cellular Targets—Iron, Cyclin-Dependent Kinase (CDK) 2, and CDK9Kalinowski, Danuta; Lovejoy, David; Richardson, Desi; Ammosova, Tatyana; Breuer, Denitra; Debebe, Zufan; Gordeuk, Victor R.; Jarebtsova, Marina; Karla, Pradeep; Kashanchi, Fatah; Kumar, Krishna; Nekhai, Sergei; Ray, Patricio E.; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyIron Chelators of the Di-2-pyridylketone Thiosemicarbazone and 2-Benzoylpyridine Thiosemicarbazone Series Inhibit HIV-1 Transcription: Identification of Novel Cellular Targets—Iron, Cyclin-Dependent Kinase (CDK) 2, and CDK9, Molecular Pharmacology, vol.79, 1, 2011,pp 185-196
2009Iron Chelators of the Dipyridylketone Thiosemicarbazone Class: Precomplexation and Transmetalation Effects on Anticancer ActivityKalinowski, Danuta; Lovejoy, David; Richardson, Desi; Bernhardt, Paul V.; Islam, Mohammad; Sharpe, Philip C.; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyIron Chelators of the Dipyridylketone Thiosemicarbazone Class: Precomplexation and Transmetalation Effects on Anticancer Activity, Journal of Medicinal Chemistry, vol.52,(2),2009,pp 407-415
2010Iron Chelators: Development of Novel Compounds with High and Selective Anti-Tumour ActivityKalinowski, Danuta; Kovacevic, Zaklina; Lovejoy, David; Quach, Patricia; Richardson, Desi; Wong, Jennifer; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Molecular BioscienceIron Chelators: Development of Novel Compounds with High and Selective Anti-Tumour Activity, Current Drug Delivery, vol.7, 3,pp 194-207
2010The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation: An EPR studyHawkins, Clare; Jansson, Jan; Lovejoy, David; Richardson, Desi; Central Clinical School: Heart Research Institute; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyThe iron complex of Dp44mT is redox-active and induces hydroxyl radical formation: An EPR study, Journal of Inorganic Biochemistry, vol.104, 11,pp 1224-1228
2010Membrane Transport and Intracellular Sequestration of Novel Thiosemicarbazone Chelators for the Treatment of CancerKalinowski, Danuta; Lovejoy, David; Merlot, Angelica; Pantarat, Namfon; Richardson, Desi; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Bosch Institute; Western Clinical School: Westmead Millennium Institute; School of Medical Sciences: PathologyMembrane Transport and Intracellular Sequestration of Novel Thiosemicarbazone Chelators for the Treatment of Cancer, Molecular Pharmacology, vol.78, 4,pp 675-684
2012Methemoglobin Formation by Triapine, Di-2-pyridylketone-4,4-dimethyl-3- thiosemicarbazone (Dp44mT), and Other Anticancer Thiosemicarbazones: Identification of Novel Thiosemicarbazones and Therapeutics That Prevent This EffectGutierrez, Elaine; Jansson, Jan (Patric); Kalinowski, Danuta; Lovejoy, David; Quach, Patricia; Richardson, Desi (Des); Basha, Maram; Bernhardt, Paul V.; Sharpe, Philip C.; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyMethemoglobin Formation by Triapine, Di-2-pyridylketone-4,4-dimethyl-3- thiosemicarbazone (Dp44mT), and Other Anticancer Thiosemicarbazones: Identification of Novel Thiosemicarbazones and Therapeutics That Prevent This Effect, Molecular Pharmacology, vol.82, 1, 2012,pp 105-114
2011Novel thiosemicarbazone iron chelators induce up-regulation and phosphorylation of the metastasis suppressor, NDRG1: A new strategy for the treatment of pancreatic cancerChikhani, Sherin; Kovacevic, Zaklina; Lovejoy, David; Richardson, Desi; School of Medical Sciences: Bosch Institute; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyNovel thiosemicarbazone iron chelators induce up-regulation and phosphorylation of the metastasis suppressor, NDRG1: A new strategy for the treatment of pancreatic cancer, Molecular Pharmacology, vol.80, 4, 2011,pp 598-609
2009Thiosemicarbazones from the Old to New: Iron Chelators That Are More Than Just Ribonucleotide Reductase InhibitorsJansson, Patric; Kalinowski, Danuta; Kovacevic, Zaklina; Lovejoy, David; Richardson, Desi (Des); Siafakas, Aritee Rosemary; Stefani, Christian; Yu, Yu; Bernhardt, Paul V.; Sharpe, Philip C; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyThiosemicarbazones from the Old to New: Iron Chelators That Are More Than Just Ribonucleotide Reductase Inhibitors, Journal of Medicinal Chemistry, vol.52, 17, 2009,pp 5271-5294