Browsing by Author Little, Christopher

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Issue DateTitleAuthor(s)Citation
20121H NMR spectroscopy of serum reveals unique metabolic fingerprints associated with subtypes of surgically induced osteoarthritis in sheepBurkhardt, Daniel; Fuller, Emily; Little, Christopher; Bateman, John; Cake, Martin; Coles, Chantal; Maher, Anthony; McDonagh, M B; Read, Richard; Rochfort, Simone Jane; White, Jason; Northern Clinical School: Surgery; Northern Clinical School: Inst. for Bone & Joint Research; Northern Clinical School: Kolling Institute1H NMR spectroscopy of serum reveals unique metabolic fingerprints associated with subtypes of surgically induced osteoarthritis in sheep, Journal of Proteome Research, vol.11, 8, 2012,pp 4261-4268
2016Ablation of Perlecan domain I heparan sulfate reduces progressive cartilage degradation, synovitis, and osteophyte size in post-traumatic osteoarthritisJackson, Miriam; Little, Christopher; Melrose, James; Shu, Cindy; Smith, Margaret; Smith, Susan; Lord, Megan; Penm, Steven; Whitelock, John M.; Northern Clinical School: Kolling Institute; Northern Clinical School: Kolling Institute; Northern Clinical School: Surgery; Northern Clinical School: Inst. for Bone & Joint Research; Northern Clinical School: Inst. for Bone & Joint Research; Northern Clinical School: Inst. for Bone & Joint ResearchAblation of Perlecan domain I heparan sulfate reduces progressive cartilage degradation, synovitis, and osteophyte size in post-traumatic osteoarthritis, Arthritis & Rheumatology, vol.68, 4, 2016,pp 868-879
2009Activated protein C mediates a healing phenotype in cultured tenocytesJackson, Christopher; Little, Christopher; March, Lyn; Sambrook, Philip; Smith, Margaret; Xue, Meilang; Northern Clinical School: Medicine; Northern Clinical School: Kolling Institute; Northern Clinical School: Medicine; Northern Clinical School: Medicine; Northern Clinical School: Inst. for Bone & Joint Research; Northern Clinical School: MedicineActivated protein C mediates a healing phenotype in cultured tenocytes, Journal of Cellular and Molecular Medicine, vol.13,(4),2009,pp 749-757
2009Activation of Cartilage Matrix Metalloproteinases by Activated Protein CJackson, Christopher; Jackson, Miriam; Little, Christopher; Smith, Margaret; Smith, Susan; Xue, Meilang; Northern Clinical School: Medicine; Northern Clinical School: Kolling Institute; Northern Clinical School: Surgery; Northern Clinical School: Inst. for Bone & Joint Research; Northern Clinical School: Inst. for Bone & Joint Research; Northern Clinical School: MedicineActivation of Cartilage Matrix Metalloproteinases by Activated Protein C, Arthritis and Rheumatism, vol.60,(3),2009,pp 780-791
2014Activation of matrix metalloproteinases 2, 9, and 13 by activated protein c in human osteoarthritic cartilage chondrocytesBabak, Moradi; Jackson, Christopher; Jackson, Miriam; Little, Christopher; Smith, Margaret; Northern Clinical School: Kolling Institute; Northern Clinical School: Medicine; Northern Clinical School: Kolling Institute; Northern Clinical School: Kolling Institute; Northern Clinical School: Inst. for Bone & Joint ResearchActivation of matrix metalloproteinases 2, 9, and 13 by activated protein c in human osteoarthritic cartilage chondrocytes, Arthritis & Rheumatology, vol.66, 6, 2014,pp 1525-1536
2004ADAMTS-1 knockout mice do not exhibit abnormalities in aggrecan turnover in-vivo or in-vitroLittle, Christopher; Fosang, A; Meeker, C T; Mittaz, Laureane; Pritchard, Melanie A.; Northern Clinical School: SurgeryADAMTS-1 knockout mice do not exhibit abnormalities in aggrecan turnover in-vivo or in-vitro, Orthopaedic Research Society. Transactions of the Annual Meeting, vol.29,(),2004,pp poster No: 0608-N/A
2005ADAMTS-5 is the major aggrecanase in cartilage: in vitro studies with ADAMTS-4 and ADAMTS-5 deficient miceLittle, Christopher; East, Charlotte J.; Fosang, A; Golub, Suzanne B.; Lawlor, Kate E.; Rogerson, Fraser M.; Stanton, Heather; Northern Clinical School: SurgeryADAMTS-5 is the major aggrecanase in cartilage: in vitro studies with ADAMTS-4 and ADAMTS-5 deficient mice, Transactions of 51st Annual Meeting of Orthopaedic Research Society, Feb 20–23, Washington, DC, vol.30,(),2005,pp N/A-N/A
2005ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.Little, Christopher; Campbell, Ian K.; East, Charlotte J.; Farmer, Pamela J.; Fosang, Amanda J.; Fourie, Anne M.; Golub, Suzanne B.; Last, Karena; Lawlor, Kate E.; Meeker, Clare T.; Rogerson, Fraser M.; Stanton, Heather; Northern Clinical School: SurgeryADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro., Nature, vol.434,(7033),2005,pp 648-652
2007Aggrecan, versican and type VI collagen are components of annular translamellar crossbridges in the intervertebral discAppleyard, Richard; Little, Christopher; Melrose, James; Smith, Susan; Medicine; Northern Clinical School: Surgery; Northern Clinical School: Surgery; Northern Clinical School: Inst. for Bone & Joint ResearchAggrecan, versican and type VI collagen are components of annular translamellar crossbridges in the intervertebral disc, European Spine Journal, vol.Published online: 31 October 2007,(N/A),2007,pp N/A-N/A
2013Altered stress induced by partial transection of the infraspinatus tendon leads to perlecan (HSPG2) accumulation in an ovine model of tendinopathyDart, Andrew; Little, Christopher; Melrose, James; Ravi, Varshini; Smith, Margaret; Smith, Susan; Sonnabend, David; Young, A; Vet Science Faculty; Northern Clinical School: Kolling Institute; Northern Clinical School: Surgery; Northern Clinical School: Kolling Institute; Northern Clinical School: Inst. for Bone & Joint Research; Northern Clinical School: Inst. for Bone & Joint Research; Northern Clinical School: SurgeryAltered stress induced by partial transection of the infraspinatus tendon leads to perlecan (HSPG2) accumulation in an ovine model of tendinopathy, Tissue and Cell, vol.45, 1, 2013,pp 77-82
2010Anti-IgD antibody attenuates collagen-induced arthritis by selectively depleting mature B-cells and promoting immune toleranceGallery, Eileen; Jackson, Christopher; Little, Christopher; McCracken, Sharon; Morris, Jonathan; Nguyen, Tue; Stevens, Veronica; Warning, Julia; Yenson, Vanessa; Northern Clinical School: Medicine; Northern Clinical School: Medicine; Northern Clinical School: Kolling Institute; Medicine; Northern Clinical School: Obstetrics & Gynaecology; Northern Clinical School: Kolling Institute; Northern Clinical School: Medicine; Northern Clinical School: Kolling Institute; Northern Clinical School: Kolling InstituteAnti-IgD antibody attenuates collagen-induced arthritis by selectively depleting mature B-cells and promoting immune tolerance, Journal of Autoimmunity, vol.35, 1,pp 86-97
2007Are animal models useful for studying human disc disorders/degeneration?Little, Christopher; Melrose, James; Alini, Mauro; Eisenstein, Stephen M; Ito, Keito; Kettler, A; Masuda, Koichi; Ralphs, Jim; Stokes, Ian; Wilke, Hans Joachim; Northern Clinical School: Surgery; Northern Clinical School: SurgeryAre animal models useful for studying human disc disorders/degeneration?, European Spine Journal, vol.Published online: 14 July 2007,(0),2007,pp 0-N/A
2007Biglycan and fibromodulin fragmentation correlates with temporal and spatial annular remodelling in experimentally injured ovine intervertebral discsDart, Andrew; Fuller, Emily; Little, Christopher; Melrose, James; Smith, Susan; Young, Allan; Roughley, Peter J; Vet Science Faculty; Northern Clinical School: Inst. for Bone & Joint Research; Northern Clinical School: Surgery; Northern Clinical School: Surgery; Northern Clinical School: Inst. for Bone & Joint Research; Northern Clinical School: MedicineBiglycan and fibromodulin fragmentation correlates with temporal and spatial annular remodelling in experimentally injured ovine intervertebral discs, European Spine Journal, vol.16,(12),2007,pp 2193-2205
2007Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repairLittle, Christopher; Smith, Susan; Farmer, Pamela J.; Fosang, Amanda J.; Golub, Suzanne; Lawlor, Kate E.; Meeker, Clare T.; Northern Clinical School: Surgery; Northern Clinical School: Inst. for Bone & Joint ResearchBlocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair, Journal of Clinical Investigation, vol.117,(6),2007,pp 1627-1636
2009Calcification in the ovine intervertebral disc: a model of hydroxyapatite deposition diseaseBurkhardt, Daniel; Little, Christopher; Melrose, James; Taylor, Thomas; Cake, Martin A.; Dillon, Carolyn T.; Read, Richard A; Northern Clinical School: Surgery; Northern Clinical School: Kolling Institute; Northern Clinical School: Surgery; Northern Clinical School: SurgeryCalcification in the ovine intervertebral disc: a model of hydroxyapatite deposition disease, European Spine Journal, vol.18,(4),2009,pp 479-489
2014Can Proinflammatory Cytokine Gene Expression Explain Multifidus Muscle Fiber Changes After an Intervertebral Disc Lesion?Little, Christopher; Melrose, James; Shu, Cindy; Blomster, Linda; Hall, Leanne; Hodges, Paul; James, Gregory; Schmid, Annina; Northern Clinical School: Kolling Institute; Northern Clinical School: Surgery; Northern Clinical School: Inst. for Bone & Joint ResearchCan Proinflammatory Cytokine Gene Expression Explain Multifidus Muscle Fiber Changes After an Intervertebral Disc Lesion?, Spine, vol.39, 13, 2014,pp 1010-1017
2011Cartilage Intermediate Layer Protein 2 (CILP-2) Is Expressed in Articular and Meniscal Cartilage and Down-regulated in Experimental OsteoarthritisLittle, Christopher; Bateman, John; Belluoccio, Daniele; Bernardo, Bianca; Hansen, Uwe; Rowley, Lynn; Northern Clinical School: Kolling InstituteCartilage Intermediate Layer Protein 2 (CILP-2) Is Expressed in Articular and Meniscal Cartilage and Down-regulated in Experimental Osteoarthritis, Journal of Biological Chemistry, vol.286, 43, 2011,pp 37758-37767
2001Catabolism of aggrecan by cells derived from osteoarthritic boneLittle, Christopher; Diffin, FM; Elson, C J; Westacott, C I; Northern Clinical School: SurgeryCatabolism of aggrecan by cells derived from osteoarthritic bone, N/A, vol.N/A,(),2001,pp N/A-N/A
2008Changes in gait after bilateral meniscectomy in sheep: effect of two hyaluronan preparationsBurkhardt, Daniel; Ghosh, Peter; Little, Christopher; Smith, Margaret; Cake, M A; Edwards, Scott; Read, R. A.; Northern Clinical School: Surgery; Northern Clinical School: Surgery; Northern Clinical School: Kolling Institute; Northern Clinical School: Inst. for Bone & Joint ResearchChanges in gait after bilateral meniscectomy in sheep: effect of two hyaluronan preparations, Journal of orthopaedic science, vol.13, 6, 2008,pp 514-523
2012Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint developmentLittle, Christopher; Melrose, James; Smith, Susan; Caterson, Bruce; Hayes, Anthony; Hughes, Clare E.; Isaacs, Marc; Northern Clinical School: Kolling Institute; Northern Clinical School: Surgery; Northern Clinical School: Inst. for Bone & Joint ResearchChondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development, Histochemistry and Cell Biology, vol.138, 3, 2012,pp 461-475