Browsing by Author Leach, Katie

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Issue DateTitleAuthor(s)Citation
2015Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimeticsConigrave, Arthur; Christopoulos, Arthur; Cook, Anna; Furness, S G B; Gregory, K J; Leach, Katie; Mistry, S N; Scammells, Peter J.; Sexton, Patrick; Molecular BioscienceBiased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics, British Journal of Pharmacology, vol.172, 1, 2015,pp 185-200
2013Calcium-sensing receptor-dependent activation of CREB phosphorylation in HEK293 cells and human parathyroid cellsAvlani, Vimesh; Conigrave, Arthur; Delbridge, Leigh; Ma, Wenting; Mun, Hee-Chang; Christopoulos, Arthur; Leach, Katie; Molecular Bioscience; Molecular Bioscience; Northern Clinical School: Surgery; Molecular Bioscience; Molecular BioscienceCalcium-sensing receptor-dependent activation of CREB phosphorylation in HEK293 cells and human parathyroid cells, American Journal of Physiology: Endocrinology and Metabolism (Print), vol.304, 10, 2013,pp E1097-E1104
2013Impact of clinically relevant mutations on the pharmacoregulation and signaling bias of the calcium-sensing receptor by positive and negative allosteric modulatorsConigrave, Arthur; Christopoulos, Arthur; Cook, Anna; Leach, Katie; Sexton, Patrick M.; Wen, Adriel; Molecular BioscienceImpact of clinically relevant mutations on the pharmacoregulation and signaling bias of the calcium-sensing receptor by positive and negative allosteric modulators, Endocrinology, vol.154, 3, 2013,pp 1105-1116
2012Positive and Negative Allosteric Modulators Promote Biased Signaling at the Calcium-Sensing ReceptorConigrave, Arthur; Christopoulos, Arthur; Davey, Anna; Leach, Katie; Sexton, PM; Valant, Celine; Molecular BiosciencePositive and Negative Allosteric Modulators Promote Biased Signaling at the Calcium-Sensing Receptor, Endocrinology, vol.153, 3, 2012,pp 1232-1241
2015Receptor expression modulates calcium-sensing receptor mediated intracellular Ca2+ mobilizationBrennan, Sarah; Conigrave, Arthur; Kuchel, Philip; Mun, Hee-Chang; Christopoulos, Arthur; Leach, Katie; Molecular Bioscience; Molecular Bioscience; Molecular Bioscience; Molecular BioscienceReceptor expression modulates calcium-sensing receptor mediated intracellular Ca2+ mobilization, Endocrinology, vol.156, 4, 2015,pp 1330-1342
2014Roles of intraloops-2 and -3 and the proximal C-terminus in signalling pathway selection from the human calcium-sensing receptorAvlani, Vimesh Ashvinkumar; Conigrave, Arthur; Khan, Mahvash; Ward, James; Christopoulos, Arthur; Leach, Katie; Molecular Bioscience; Molecular Bioscience; Molecular Bioscience; Molecular BioscienceRoles of intraloops-2 and -3 and the proximal C-terminus in signalling pathway selection from the human calcium-sensing receptor, FEBS Letters, vol.588, 18, 2014,pp 3340-3346
2015Towards tissue-specific pharmacology: insights from the calcium-sensing receptor as a paradigm for GPCR (patho)physiological biasConigrave, Arthur; Christopoulos, Arthur; Leach, Katie; Sexton, Patrick; Molecular BioscienceTowards tissue-specific pharmacology: insights from the calcium-sensing receptor as a paradigm for GPCR (patho)physiological bias, Trends In Pharmacological Sciences, vol.36, 4, 2015,pp 215-225