Browsing by Author Kakavand, Hojabr

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Issue DateTitleAuthor(s)Citation
2016BRAF(V600E) and NRAS(Q61L/Q61R) mutation analysis in metastatic melanoma using immunohistochemistry: a study of 754 cases highlighting potential pitfalls and guidelines for interpretation and reportingCooper, Wendy Anne; Kakavand, Hojabr; Long, Georgina; O'Toole, Sandra; Saw, Robyn; Scolyer, Richard; Smith, Elisabeth; Walker, Emily; Wilmott, James; Yu, Bing; Lum, Trina; Selinger, Christina; Central Clinical School: Medicine; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Central Clinical School: The Sydney Cancer Centre; Central Clinical School: Pathology; Central Clinical School: Surgery; Central Clinical School: Pathology; Central Clinical School: Medicine; Medicine; Central Clinical School: Surgery; Central Clinical School: MedicineBRAF(V600E) and NRAS(Q61L/Q61R) mutation analysis in metastatic melanoma using immunohistochemistry: a study of 754 cases highlighting potential pitfalls and guidelines for interpretation and reporting, Histopathology, vol.69, 4, 2016,pp 680-686
2013BRAF/NRAS Wild-Type Melanomas Have a High Mutation Load Correlating with Histologic and Molecular Signatures of UV DamageKakavand, Hojabr; Mann, Graham; Scolyer, Richard; Thompson, John; Behren, Andreas; Cebon, Jonathan Simon; Dobrovic, Alexander; Kelly, John; Li, Jason; Mar, Victoria; McArthur, Grant A.; McLean, Catriona; Papenfuss, Anthony Troy; Tothill, Richard W.; Wolfe, Rory; Wong, Stephen; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Western Clinical School: Westmead Millennium Institute; Central Clinical School: Pathology; Central Clinical School: SurgeryBRAF/NRAS Wild-Type Melanomas Have a High Mutation Load Correlating with Histologic and Molecular Signatures of UV Damage, Clinical Cancer Research, vol.19, 17, 2013,pp 4589-4598
2016Comparison of whole-exome sequencing of matched fresh and formalin fixed paraffin embedded melanoma tumours: implications for clinical decision makingKakavand, Hojabr; Long, Georgina; Mann, Graham; Menzies, Alexander Maxwel; Pupo, Gulietta; Scolyer, Richard; Wilmott, James; De Paoli-Iseppi, Ricardo; Dias, Kerith-Rae; Dinger, Marcel; Hayward, Nicholas K; Johansson, Peter; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Central Clinical School: The Sydney Cancer Centre; Western Clinical School: Westmead Institute for Medical Res; Central Clinical School: Medicine; Western Clinical School: Medicine (Westmead); Central Clinical School: Pathology; Central Clinical School: SurgeryComparison of whole-exome sequencing of matched fresh and formalin fixed paraffin embedded melanoma tumours: implications for clinical decision making, Pathology, vol.48, 3, 2016,pp 261-266
2014Concordant BRAFV600E mutation status in primary melanomas and associated naevi: implications for mutation testing of primary melanomasKakavand, Hojabr; Kefford, Richard (Rick); Long, Georgina; O'Toole, Sandra; Scolyer, Richard; Thompson, John; Wilmott, James; Crainic, Oana; Lum, Trina; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Western Clinical School: Westmead Millennium Institute; Central Clinical School: The Sydney Cancer Centre; Central Clinical School: Pathology; Central Clinical School: Pathology; Central Clinical School: Surgery; Central Clinical School: SurgeryConcordant BRAFV600E mutation status in primary melanomas and associated naevi: implications for mutation testing of primary melanomas, Pathology, vol.46, 3, 2014,pp 193-198
2014Correlation of BRAF and NRAS mutation status with outcome, site of distant metastasis and response to chemotherapy in metastatic melanomaCarlino, Matteo; Hamilton, Anne; Haydu, Lauren; Kakavand, Hojabr; Kefford, Richard (Rick); Long, Georgina; Menzies, Alexander Maxwel; O'Toole, Sandra; Scolyer, Richard; Thompson, John; Yu, Bing; Cooper, Wendy; Ng, C; Western Clinical School: Medicine (Westmead); Central Clinical School: Medicine; Central Clinical School: Surgery; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Western Clinical School: Westmead Millennium Institute; Central Clinical School: The Sydney Cancer Centre; Central Clinical School: Medicine; Central Clinical School: Pathology; Central Clinical School: Pathology; Central Clinical School: Surgery; Central Clinical School: MedicineCorrelation of BRAF and NRAS mutation status with outcome, site of distant metastasis and response to chemotherapy in metastatic melanoma, British Journal of Cancer, vol.111, 2, 2014,pp 292-299
2017Dynamic changes in PD-L1 expression and immune infiltrates early during treatment predict response to PD-1 blockade in MelanomaCarlino, Matteo; Guminski, Alexander; Jakrot, Valerie; Kakavand, Hojabr; Kefford, Richard (Rick); Liniker, Elizabeth; Lo, Serigne; Long, Georgina; Madore, Jason; Menzies, Alexander Maxwel; Saw, Robyn; Scolyer, Richard; Thompson, John; Vilain, Ricardo; Wilmott, James; Cooper, Adam J.; Howle, Julie; Kong, Benjamin; Westmead Clinical School: Medicine; Northern Clinical School: Medicine; Northern Clinical School: Medicine; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Westmead Clinical School: Medicine; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Central Clinical School: Medicine; Northern Clinical School: Medicine; Central Clinical School: Medicine; Northern Clinical School: Medicine; Central Clinical School: Surgery; Central Clinical School: Pathology; Central Clinical School: Surgery; Central Clinical School: Pathology; Central Clinical School: SurgeryDynamic changes in PD-L1 expression and immune infiltrates early during treatment predict response to PD-1 blockade in Melanoma, Clinical Cancer Research, vol.23, 17, 2017,pp 5024-5033
2015Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathwayMann, Graham; Scolyer, Richard; Thompson, John; Botton, Thomas; Chung, Jongsuk; et al, Various; Garrido, Maria; Kakavand, Hojabr; Sanborn, J Zachary; Shain, A Hunter; Talevich, Eric; Wang, Nicholas J; Wiesner, Thomas; Yeh, Iwei; Western Clinical School: Westmead Institute for Medical Res; Central Clinical School: Pathology; Central Clinical School: SurgeryExome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway, Nature Genetics, vol.47, 10, 2015,pp 1194-1199
2015Expression of the class 1 histone deacetylases HDAC8 and 3 are associated with improved survival of patients with metastatic melanomaCarlino, Matteo; Colebatch, Andrew; Hersey, Peter; Kakavand, Hojabr; Long, Georgina; Scolyer, Richard; Thompson, John; Wilmott, James; Shang, Ping; Western Clinical School: Medicine (Westmead); Medicine; Northern Clinical School: Surgery; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Central Clinical School: The Sydney Cancer Centre; Central Clinical School: Pathology; Central Clinical School: Surgery; Central Clinical School: SurgeryExpression of the class 1 histone deacetylases HDAC8 and 3 are associated with improved survival of patients with metastatic melanoma, Modern Pathology, vol.28, 7, 2015,pp 884-894
2014Genetic and clinico-pathologic analysis of metastatic uveal melanomaHaydu, Lauren; Kakavand, Hojabr; Scolyer, Richard; Thompson, John; Asher, Marina; Griewank, Klaus; Hillen, Uwe; Moll, Iris; Murali, Rajmohan; Schadendorf, Dirk; Schilling, Bastian; Sucker, Antje; van de Nes, Johannes; Zimmer, Lisa; Central Clinical School: Surgery; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Central Clinical School: Pathology; Central Clinical School: SurgeryGenetic and clinico-pathologic analysis of metastatic uveal melanoma, Modern Pathology, vol.27, 2, 2014,pp 175-183
2013Identification of new prognostic biomarkers for Stage III metastatic melanoma patientsKakavand, Hojabr; Mann, Graham; Scolyer, Richard; Thompson, John; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Western Clinical School: Westmead Millennium Institute; Central Clinical School: Pathology; Central Clinical School: SurgeryIdentification of new prognostic biomarkers for Stage III metastatic melanoma patients, OncoImmunology, vol.2, 9, 2013,pp e25564-1-e25564-3
2012Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of MelanomaKakavand, Hojabr; Scolyer, Richard; Thompson, John; Ceol, Craig; Dresser, Karen; et al, Various; Hu, Yeguang; Larson, Allison; Lian, Christine; Tan, Li; Wu, Feizhen; Xu, Wenqi; Xu, Yufei; Zhan, Qian; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Central Clinical School: Pathology; Central Clinical School: SurgeryLoss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma, Cell, vol.150, 6, 2012,pp 1135-1146
2017Negative immune checkpoint regulation by VISTA: A mechanism of acquired resistance to anti-PD-1 therapy in metastatic melanoma patientsCarlino, Matteo; Gide, Tuba; Jackett, Louise; Kakavand, Hojabr; Long, Georgina; Menzies, Alexander Maxwel; Saw, Robyn; Scolyer, Richard; Thompson, John; Wilmott, James; Westmead Clinical School: Medicine; Physiology; Central Clinical School: Medicine; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Northern Clinical School: Medicine; Northern Clinical School: Medicine; Central Clinical School: Surgery; Central Clinical School: Pathology; Central Clinical School: Surgery; Central Clinical School: SurgeryNegative immune checkpoint regulation by VISTA: A mechanism of acquired resistance to anti-PD-1 therapy in metastatic melanoma patients, Modern Pathology, vol.30, 12, 2017,pp 1666-1676
2017PD-L1 expression and immune escape in melanoma resistance to MAPK inhibitorsCarlino, Matteo; Howle, Julie; Kakavand, Hojabr; Long, Georgina; Menzies, Alexander Maxwel; Pupo, Gulietta; Saw, Robyn; Scolyer, Richard; Thompson, John; Wilmott, James; Yang, Jean Yee Hwa; Kefford, Richard; Rawson, Robert; Rizos, Helen; Westmead Clinical School: Medicine; Westmead Clinical School: Surgery; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Northern Clinical School: Medicine; Northern Clinical School: Medicine; Westmead Clinical School: Medicine; Central Clinical School: Surgery; Central Clinical School: Pathology; Central Clinical School: Surgery; Central Clinical School: Surgery; Mathematics & StatisticsPD-L1 expression and immune escape in melanoma resistance to MAPK inhibitors, Clinical Cancer Research, vol.23, 20, 2017,pp 6054-6061
2015PD-L1 expression and tumor-infiltrating lymphocytes define different subsets of MAPK inhibitor treated melanoma patientsHaydu, Lauren; Hersey, Peter; Kakavand, Hojabr; Kefford, Richard (Rick); Long, Georgina; Menzies, Alexander Maxwel; Scolyer, Richard; Thompson, John; Vilain, Ricardo; Wilmott, James; Yearley, Jennifer H; Central Clinical School: Surgery; Northern Clinical School: Surgery; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Western Clinical School: Westmead Millennium Institute; Central Clinical School: The Sydney Cancer Centre; Central Clinical School: Medicine; Central Clinical School: Pathology; Central Clinical School: Surgery; Central Clinical School: Pathology; Central Clinical School: SurgeryPD-L1 expression and tumor-infiltrating lymphocytes define different subsets of MAPK inhibitor treated melanoma patients, Clinical Cancer Research, vol.21, 14, 2015,pp 3140-3148
2015PD-L1 expression in melanoma shows marked heterogeneity within and between patients: Implications for anti-PD-1/PD-L1 clinical trialsHersey, Peter; Kakavand, Hojabr; Kefford, Richard (Rick); Long, Georgina; Madore, Jason; Menzies, Alexander Maxwel; Scolyer, Richard; Thompson, John; Vilain, Ricardo; Wilmott, James; Hyman, Jessica; Yearley, Jennifer H; Northern Clinical School: Surgery; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Western Clinical School: Westmead Millennium Institute; Central Clinical School: The Sydney Cancer Centre; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Central Clinical School: Medicine; Central Clinical School: Pathology; Central Clinical School: Surgery; Central Clinical School: Pathology; Central Clinical School: SurgeryPD-L1 expression in melanoma shows marked heterogeneity within and between patients: Implications for anti-PD-1/PD-L1 clinical trials, Pigment Cell & Melanoma Research, vol.28, 3, 2015,pp 245-253
2015Phylogenetic analyses of melanoma reveal complex patterns of metastatic disseminationMann, Graham; Saw, Robyn; Scolyer, Richard; Thompson, John; Wilmott, James; Bastian, Boris; Busam, Klaus Johannes; Butler, Timothy; Cho, Raymond J; Chung, Jongsuk; Cleaver, James E; Collisson, Eric A; Gray, Joe W; Haydu, Lauren; Huh, Nam; Hur, Joe S; Kakavand, Hojabr; Lo, Roger; Murali, Rajmohan; Purdom, Elizabeth A; Sanborn, J Zachary; Spellman, Paul T; Wang, Nicholas J; Western Clinical School: Westmead Institute for Medical Res; Central Clinical School: Surgery; Central Clinical School: Pathology; Central Clinical School: Surgery; Central Clinical School: SurgeryPhylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination, Proceedings of the National Academy of Sciences of the United States of America (PNAS), vol.112, 35, 2015,pp 10995-11000
2016Targeted therapies and immune checkpoint inhibitors in the treatment of metastatic melanoma patients: a guide and update for pathologistsKakavand, Hojabr; Long, Georgina; Scolyer, Richard; Wilmott, James; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Central Clinical School: The Sydney Cancer Centre; Central Clinical School: Pathology; Central Clinical School: SurgeryTargeted therapies and immune checkpoint inhibitors in the treatment of metastatic melanoma patients: a guide and update for pathologists, Pathology, vol.48, 2, 2016,pp 194-202
2015Tumor PD-L1 expression, immune cell correlates and PD-1+ lymphocytes in sentinel lymph node melanoma metastasesHersey, Peter; Kakavand, Hojabr; Long, Georgina; Scolyer, Richard; Thompson, John; Wilmott, James; Burke, Hazel; Vilain, Ricardo E; Yearley, Jennifer H; Northern Clinical School: Surgery; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Central Clinical School: The Sydney Cancer Centre; Central Clinical School: Pathology; Central Clinical School: Surgery; Central Clinical School: SurgeryTumor PD-L1 expression, immune cell correlates and PD-1+ lymphocytes in sentinel lymph node melanoma metastases, Modern Pathology, vol.28, 12, 2015,pp 1535-1544
2015Tumour procurement, DNA extraction, coverage analysis and optimisation of mutation-detection algorithms for human melanoma genomesKakavand, Hojabr; Mann, Graham; Pupo, Gulietta; Scolyer, Richard; Tembe, Varsha; Thompson, John; Vilain, Ricardo; Wilmott, James; Cebon, Jonathan; De Paoli-Iseppi, Ricardo; Field, Matthew; Fitzgerald, Anna; Hayward, Nicholas K; Jakrot, Valerie; Johansson, Peter; Shackleton, Mark; Shang, Catherine A; Shang, Ping; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Western Clinical School: Westmead Institute for Medical Res; Western Clinical School: Medicine (Westmead); Central Clinical School: Pathology; Western Clinical School: Westmead Institute for Medical Res; Central Clinical School: Surgery; Central Clinical School: Pathology; Central Clinical School: SurgeryTumour procurement, DNA extraction, coverage analysis and optimisation of mutation-detection algorithms for human melanoma genomes, Pathology, vol.47, 7, 2015,pp 683-693
2017Whole-genome landscapes of major melanoma subtypesBurke, Hazel; Dagg, Rebecca; De Paoli-Iseppi, Ricardo; Hayward, Nicholas; Hersey, Peter; Jakrot, Valerie; Kakavand, Hojabr; Kefford, Richard (Rick); Lau, Loretta; Long, Georgina; Mann, Graham; Pickett, Hilda; Pupo, Gulietta; Saw, Robyn; Schramm, Sarah-Jane; Scolyer, Richard; Shang, Ping; Spillane, Andrew; Stretch, Jonathan; Tembe, Varsha; Thompson, John; Vilain, Ricardo; Wilmott, James; Yang, Jean Yee Hwa; Alexandrov, L; Behren, A; Cebon, Jonathan Simon; Dutton-Regester, K; Field, M; Fitzgerald, A; Grimmond, Sean Michael; Holmes, O; Johansson, P; Kazakoff, S; Leonard, Conrad; Lopez-Bigas, Nuria; Mularoni, L; Newell, F; Nones, Katia; Patch, Anne-Marie; Pearson, John V; Pritchard, Antonia L; Sabarinathan, R; Shackleton, Mark; Shang, C; Waddell, Nick; Waddell, Nicola; Wood, Scott; Xu, Qingying; Melanoma Foundation; School of Molecular Bioscience (SMB); Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Medicine Faculty Office; Northern Clinical School: Surgery; Northern Clinical School: Medicine; Central Clinical School: Melonoma & Skin Cancer Res. Inst.; Western Clinical School: Medicine (Westmead); Childrens Hospital Westmead: Paediatrics & Child Health; Northern Clinical School: Medicine; Western Clinical School: Westmead Institute for Medical Res; Childrens Medical Research Institute (CMRI); Western Clinical School: Medicine (Westmead); Central Clinical School: Surgery; Western Clinical School: Medicine (Westmead); Central Clinical School: Pathology; Northern Clinical School: Kolling Institute; Northern Clinical School: Surgery; Central Clinical School: Surgery; Western Clinical School: Westmead Institute for Medical Res; Central Clinical School: Surgery; Central Clinical School: Pathology; Central Clinical School: Surgery; Mathematics & StatisticsWhole-genome landscapes of major melanoma subtypes, Nature, vol.545, 7653, 2017,pp 175-180