Browsing by Author Jansson, Patric

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Issue DateTitleAuthor(s)Citation
2014The Anti-Cancer Agent, Dp44mT, Overcomes Pro-Survival Autophagy by Two Mechanisms: Persistent Induction of Autophagosome Synthesis and Impairment of Lysosomal IntegrityGutierrez, Elaine; Jansson, Patric; Richardson, Desi (Des); School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyThe Anti-Cancer Agent, Dp44mT, Overcomes Pro-Survival Autophagy by Two Mechanisms: Persistent Induction of Autophagosome Synthesis and Impairment of Lysosomal Integrity, The Journal of Biological Chemistry, vol.289, 48, 2014,pp 33568-33589
2011Antitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in LysosomesBrunk, Ulf; Jansson, Patric; Lovejoy, David; Richardson, Desi (Des); Wong, Jacky; Ponka, Prem; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyAntitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in Lysosomes, Cancer Research, vol.71, 17, 2011,pp 5871-5880
2015Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in diseaseBae, Dong-Hun; Huang, Michael; Jansson, Patric; Kalinowski, Danuta; Lane, Darius John Rowland; Merlot, Angelica; Richardson, Desi (Des); Sahni, Sumit; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Bosch Institute; School of Medical Sciences: Pathology; MedicineCellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease, Biochimica et Biophysica Acta. General Subjects, vol.1853, 5, 2015,pp 1130-1144
2015Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-Glycoprotein (Pgp)Arvind, Akanksha; Gutierrez, Elaine; Jansson, Patric; Maleki, Sanaz; Richardson, Desi (Des); Sahni, Sumit; Seebacher, Nicole; Sharp, Danae; Stacy, Alexandra Elizabeth; Yamagishi, Tetsuo; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; Northern Clinical School: Kolling Institute; School of Medical Sciences: Pathology; Medicine; Biological Sciences; Central Clinical School: Medicine; School of Medical Sciences: Pathology; School of Medical Sciences: School of Medical SciencesDi-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-Glycoprotein (Pgp), The Journal of Biological Chemistry, vol.290, 15, 2015,pp 9588-9603
2016Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug TransporterJansson, Patric; Lane, Darius John Rowland; Richardson, Desi (Des); Seebacher, Nicole; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Biological SciencesGlucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter, The Journal of Biological Chemistry, vol.291, 8, 2016,pp 3796-3820
2015Glucose modulation induces reactive oxygen species and increases P-glycoprotein-mediated multidrug resistance to chemotherapeuticsJansson, Patric; Richardson, Desi (Des); Seebacher, Nicole; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; Biological SciencesGlucose modulation induces reactive oxygen species and increases P-glycoprotein-mediated multidrug resistance to chemotherapeutics, British Journal of Pharmacology, vol.172, 10, 2015,pp 2557-2772
2015Identification of differential anti-neoplastic activity of copper bis(thiosemicarbazones) that is mediated by intracellular reactive oxygen species generation and lysosomal membrane permeabilizationAl-Eisawi, Zaynab; Jansson, Patric; Kalinowski, Danuta; Richardson, Desi (Des); Stefani, Christian; School of Medical Sciences: Biomedical Sciences; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyIdentification of differential anti-neoplastic activity of copper bis(thiosemicarbazones) that is mediated by intracellular reactive oxygen species generation and lysosomal membrane permeabilization, Journal of Inorganic Biochemistry, vol.152, N/A, 2015,pp 20-37
2016Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT)Arzuman, Laila; Gutierrez, Elaine; Jansson, Patric; Kalinowski, Danuta; Kovacevic, Zaklina; Lane, Darius John Rowland; Lok, Hiu; Merlot, Angelica; Richardson, Desi (Des); Richardson, Vera; Sahni, Sumit; Seebacher, Nicole; School of Medical Sciences: Biomedical Sciences; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Biomedical Sciences; School of Medical Sciences: Bosch Institute; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; Biological SciencesLysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT), BBA: Biochimica et Biophysica Acta - Molecular Cell Research, vol.1863, 7 Pt A, 2016,pp 1665-1681
2016A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpCJansson, Patric; Richardson, Desi (Des); Seebacher, Nicole; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Biological SciencesA mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC, Cell Death and Disease, vol.7, 12, 2016,pp 1-13
2016Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2[alpha], IRE1[alpha], ATF6 and calmodulin kinaseJansson, Patric; Kalinowski, Danuta; Kovacevic, Zaklina; Lane, Darius John Rowland; Merlot, Angelica; Richardson, Desi (Des); Richardson, Vera; Sahni, Sumit; Shafie, Nurul; Yu, Yu; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Bosch Institute; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyMechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2[alpha], IRE1[alpha], ATF6 and calmodulin kinase, Biochemical Pharmacology, vol.109, N/A, 2016,pp 27-47
2016Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2[alpha], IRE1[alpha], ATF6 and calmodulin kinaseJansson, Patric; Kalinowski, Danuta; Kovacevic, Zaklina; Lane, Darius John Rowland; Merlot, Angelica; Richardson, Desi (Des); Richardson, Vera; Sahni, Sumit; Shafie, Nurul; Yu, Yu; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Bosch Institute; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyMechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2[alpha], IRE1[alpha], ATF6 and calmodulin kinase, Biochemical Pharmacology, vol.109, N/A, 2016,pp 27-47
2017The mechanistic role of chemically diverse metal ions in the induction of autophagyBae, Dong-Hun; Jansson, Patric; Richardson, Desi (Des); Sahni, Sumit; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyThe mechanistic role of chemically diverse metal ions in the induction of autophagy, Pharmacological Research, vol.119, N/A, 2017,pp 118-127
2014The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cellsBae, Dong-Hun; Jansson, Patric; Kalinowski, Danuta; Kovacevic, Zaklina; Lane, Darius John Rowland; Richardson, Desi (Des); Sahni, Sumit; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; MedicineThe metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells, The Journal of Biological Chemistry, vol.289, 14, 2014,pp 9692-9709
2018Mitochondrial dysfunction in the neuro-degenerative and cardio-degenerative disease, Friedreich's ataxiaChiang, Shannon; Huang, Michael; Jansson, Patric; Kalinowski, Danuta; Richardson, Desi (Des); Central Clinical School: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyMitochondrial dysfunction in the neuro-degenerative and cardio-degenerative disease, Friedreich's ataxia, Neurochemistry International, vol.117, N/A, 2018,pp 35-48
2015The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: New therapeutic targetsHuang, Michael; Jansson, Patric; Kalinowski, Danuta; Kovacevic, Zaklina; Lane, Darius John Rowland; Merlot, Angelica; Richardson, Desi (Des); Richardson, Vera; Sahni, Sumit; Jin, Runsen; Liu, Wensheng; Peng, Zhihai; Wang, Puxiongzhi; Yue, Fei; Zheng, Minhua; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Bosch Institute; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyThe molecular effect of metastasis suppressors on Src signaling and tumorigenesis: New therapeutic targets, Oncotarget, vol.6, 34, 2015,pp 35522-35541
2015The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: New therapeutic targetsHuang, Michael; Jansson, Patric; Kalinowski, Danuta; Kovacevic, Zaklina; Lane, Darius John Rowland; Merlot, Angelica; Richardson, Desi (Des); Richardson, Vera; Sahni, Sumit; Jin, Runsen; Liu, Wensheng; Peng, Zhihai; Wang, Puxiongzhi; Yue, Fei; Zheng, Minhua; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Bosch Institute; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyThe molecular effect of metastasis suppressors on Src signaling and tumorigenesis: New therapeutic targets, Oncotarget, vol.6, 34, 2015,pp 35522-35541
2014Molecular Functions of the Iron-Regulated Metastasis Suppressor, NDRG1, and its Potential as a Molecular Target for Cancer TherapyFang, Bernard; Jansson, Patric; Kalinowski, Danuta; Kovacevic, Zaklina; Lane, Darius John Rowland; Park, Kyung Chan; Richardson, Desi (Des); Sahni, Sumit; Central Clinical School: Medicine; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Bosch Institute; School of Medical Sciences: Pathology; MedicineMolecular Functions of the Iron-Regulated Metastasis Suppressor, NDRG1, and its Potential as a Molecular Target for Cancer Therapy, Biochimica et Biophysica Acta (Molecular and Cell Biology of Lipids), vol.1845, 1, 2014,pp 1-19
2016A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide CytotoxicityJansson, Patric; Kovacevic, Zaklina; Lok, Hiu; Richardson, Desi (Des); Sahni, Sumit; Hawkins, Clare L.; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Biomedical Sciences; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyA Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity, Journal of Biological Chemistry, vol.291, 53, 2016,pp 27042-27061
2018Novel chelators based on adamantane-derived semicarbazones and hydrazones that target multiple hallmarks of Alzheimer's diseaseJansson, Patric; Kalinowski, Danuta; Palanimuthu, Duraippandi; Richardson, Desi (Des); Wu, Zhixuan; Bernhardt, Paul V.; Braidy, Nady; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyNovel chelators based on adamantane-derived semicarbazones and hydrazones that target multiple hallmarks of Alzheimer's disease, Dalton Transactions, vol.47, 21, 2018,pp 7190-7205
2018Novel chelators based on adamantane-derived semicarbazones and hydrazones that target multiple hallmarks of Alzheimer's diseaseJansson, Patric; Kalinowski, Danuta; Palanimuthu, Duraippandi; Richardson, Desi (Des); Wu, Zhixuan; Bernhardt, Paul V.; Braidy, Nady; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: Pathology; School of Medical Sciences: PathologyNovel chelators based on adamantane-derived semicarbazones and hydrazones that target multiple hallmarks of Alzheimer's disease, Dalton Transactions, vol.47, 21, 2018,pp 7190-7205