Browsing by Author Fosang, Amanda J.

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Issue DateTitleAuthor(s)Citation
2005ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.Little, Christopher; Campbell, Ian K.; East, Charlotte J.; Farmer, Pamela J.; Fosang, Amanda J.; Fourie, Anne M.; Golub, Suzanne B.; Last, Karena; Lawlor, Kate E.; Meeker, Clare T.; Rogerson, Fraser M.; Stanton, Heather; Northern Clinical School: SurgeryADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro., Nature, vol.434,(7033),2005,pp 648-652
2007Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repairLittle, Christopher; Smith, Susan; Farmer, Pamela J.; Fosang, Amanda J.; Golub, Suzanne; Lawlor, Kate E.; Meeker, Clare T.; Northern Clinical School: Surgery; Northern Clinical School: Inst. for Bone & Joint ResearchBlocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair, Journal of Clinical Investigation, vol.117,(6),2007,pp 1627-1636
2005Generation of mice with aggrecan resistant to aggrecanase cleavage in the IGDLittle, Christopher; Fosang, Amanda J.; Meeker, Clare T.; Northern Clinical School: SurgeryGeneration of mice with aggrecan resistant to aggrecanase cleavage in the IGD, 51st Annual Meeting of the Orthopaedic Research Society, vol.30,(N/A),2005,pp 357-N/A
2011Investigating ADAMTS-mediated aggrecanolysis in mouse cartilageLittle, Christopher; Fosang, Amanda J.; Golub, Suzanne B.; Last, Karena; Rogerson, Fraser M.; Stanton, Heather; Northern Clinical School: Kolling InstituteInvestigating ADAMTS-mediated aggrecanolysis in mouse cartilage, Nature Protocols (Online), vol.6, 3, 2011,pp 388-404
2010Is cartilage matrix breakdown an appropriate therapeutic target in osteoarthritis - insights from studies of aggrecan and collagen proteolysis?Little, Christopher; Fosang, Amanda J.; Northern Clinical School: Kolling InstituteIs cartilage matrix breakdown an appropriate therapeutic target in osteoarthritis - insights from studies of aggrecan and collagen proteolysis?, Current Drug Targets, vol.11, 5,pp 561-575
2005Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development.Little, Christopher; Fosang, Amanda J.; Golub, Suzanne B.; Hembry, Rosalind M.; Last, Karena; Lawlor, Kate E.; Meeker, Clare T.; Sims, Natalie A.; Northern Clinical School: SurgeryMatrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development., MOLECULAR AND CELLULAR BIOLOGY, Apr. 2005, vol.25,(8),2005,pp 3388-3399
2017Proteoglycan and Collagen Degradation in OsteoarthritisLittle, Christopher; Fosang, Amanda J.; Gauci, Stephanie J.; Stanton, Heather; Northern Clinical School: SurgeryProteoglycan and Collagen Degradation in Osteoarthritis in Cartilage: Volume 2: Pathophysiology, Springer International Publishing, 2017, pp. 41-61
2011Proteoglycan degradation by the ADAMTS family of proteinasesLittle, Christopher; Melrose, James; Fosang, Amanda J.; Stanton, Heather; Northern Clinical School: Kolling Institute; Northern Clinical School: SurgeryProteoglycan degradation by the ADAMTS family of proteinases, Biochimica et Biophysica Acta-Molecular Basis of Disease, vol.1812, 12, 2011,pp 1616-1629