Browsing by Author Edwards, Robert J.

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Issue DateTitleAuthor(s)Citation
2010Impaired irinotecan biotransformation in hepatic microsomal fractions from patients with chronic liver diseaseD'Esposito, Fabrizio; Murray, Michael; Nebot, Noelia; Edwards, Robert J.; Pharmacy; Pharmacy; School of Medical Sciences: PharmacologyImpaired irinotecan biotransformation in hepatic microsomal fractions from patients with chronic liver disease, British Journal of Clinical Pharmacology, vol.70, 3,pp 400-408
2009In vitro and in vivo evaluation of the inhibition potential of risperidone toward clozapine biotransformationChetty, Manoranjenni; D'Esposito, Fabrizio; Murray, Michael; Ramzan, Iqbal; Zhang, Wei; Dore, Glenys; Edwards, Robert J.; Glen, John; Stankovic, Zvijezdana; Pharmacy; Pharmacy; Pharmacy; Pharmacy; PharmacyIn vitro and in vivo evaluation of the inhibition potential of risperidone toward clozapine biotransformation, British Journal of Clinical Pharmacology, vol.68,(4),2009,pp 574-579
2008Interindividual Variation in Relative CYP1A2/3A4 Phenotype Influences Susceptibility of Clozapine Oxidation to Cytochrome P450-Specific Inhibition in Human Hepatic MicrosomesD'Esposito, Fabrizio; Murray, Michael; Ramzan, Iqbal; Zhang, Wei; Edwards, Robert J.; Pharmacy; School of Medical Sciences: Pharmacology; Pharmacy; PharmacyInterindividual Variation in Relative CYP1A2/3A4 Phenotype Influences Susceptibility of Clozapine Oxidation to Cytochrome P450-Specific Inhibition in Human Hepatic Microsomes, Drug Metabolism and Disposition, vol.36, 12, 2008,pp 2547-2555
2014The multikinase inhibitor axitinib is a potent inhibitor of human CYP1A2Gu, Rui; Hibbs, David; Murray, Michael; Ong, Jennifer; Edwards, Robert J.; Pharmacy; Pharmacy; School of Medical Sciences: Pharmacology; PharmacyThe multikinase inhibitor axitinib is a potent inhibitor of human CYP1A2, Biochemical Pharmacology, vol.88, 2, 2014,pp 245-252
2012Role of human CYP3A4 in the biotransformation of sorafenib to its major oxidized metabolitesCui, Pei (Sarah); Doddareddy, Munikumar; Ghassabian, Susan; Hibbs, David; Murray, Michael; Rawling, Tristan; Tattam, Bruce; Zhou, Fanfan; Edwards, Robert J.; Pharmacy; School of Medical Sciences: Brain & Mind Research Institute; Pharmacy; Pharmacy; Pharmacy; Pharmacy; Pharmacy; PharmacyRole of human CYP3A4 in the biotransformation of sorafenib to its major oxidized metabolites, Biochemical Pharmacology, vol.84, 2, 2012,pp 215-223