Browsing by Author D'Esposito, Fabrizio

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Issue DateTitleAuthor(s)Citation
2010Impaired irinotecan biotransformation in hepatic microsomal fractions from patients with chronic liver diseaseD'Esposito, Fabrizio; Murray, Michael; Nebot, Noelia; Edwards, Robert J.; Pharmacy; Pharmacy; School of Medical Sciences: PharmacologyImpaired irinotecan biotransformation in hepatic microsomal fractions from patients with chronic liver disease, British Journal of Clinical Pharmacology, vol.70, 3,pp 400-408
2009In vitro and in vivo evaluation of the inhibition potential of risperidone toward clozapine biotransformationChetty, Manoranjenni; D'Esposito, Fabrizio; Murray, Michael; Ramzan, Iqbal; Zhang, Wei; Dore, Glenys; Edwards, Robert J.; Glen, John; Stankovic, Zvijezdana; Pharmacy; Pharmacy; Pharmacy; Pharmacy; PharmacyIn vitro and in vivo evaluation of the inhibition potential of risperidone toward clozapine biotransformation, British Journal of Clinical Pharmacology, vol.68,(4),2009,pp 574-579
2008Interindividual Variation in Relative CYP1A2/3A4 Phenotype Influences Susceptibility of Clozapine Oxidation to Cytochrome P450-Specific Inhibition in Human Hepatic MicrosomesD'Esposito, Fabrizio; Murray, Michael; Ramzan, Iqbal; Zhang, Wei; Edwards, Robert J.; Pharmacy; School of Medical Sciences: Pharmacology; Pharmacy; PharmacyInterindividual Variation in Relative CYP1A2/3A4 Phenotype Influences Susceptibility of Clozapine Oxidation to Cytochrome P450-Specific Inhibition in Human Hepatic Microsomes, Drug Metabolism and Disposition, vol.36, 12, 2008,pp 2547-2555
2008A liquid chromatography/electrospray ionization mass spectrometry (LC-MS/MS) assay for the determination of irinotecan (CPT-11) and its two major metabolites in human liver microsomal incubations and human plasma samplesD'Esposito, Fabrizio; Murray, Michael; Ramzan, Iqbal; Tattam, Bruce; Pharmacy; Pharmacy; Pharmacy; PharmacyA liquid chromatography/electrospray ionization mass spectrometry (LC-MS/MS) assay for the determination of irinotecan (CPT-11) and its two major metabolites in human liver microsomal incubations and human plasma samples, Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, vol.875,(2),2008,pp 522-530
2010Participation of CYP2C8 and CYP3A4 in the N-demethylation of imatinib in human hepatic microsomesCrettol, Severine; D'Esposito, Fabrizio; Hibbs, David; Murray, Michael; Nebot, Noelia; Tattam, Bruce; Pharmacy; Pharmacy; Pharmacy; Pharmacy; School of Medical Sciences: Pharmacology; PharmacyParticipation of CYP2C8 and CYP3A4 in the N-demethylation of imatinib in human hepatic microsomes, British Journal of Pharmacology, vol.161, 5,pp 1059-1069