Browsing by Author Clifton, Ian J

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Showing results 1 to 11 of 11
Issue DateTitleAuthor(s)Citation
2013The crystal structure of an isopenicillin N synthase complex with an ethereal substrate analogue reveals water in the oxygen binding siteRutledge, Peter; Adlington, Robert M; Baldwin, Jack E; Clifton, Ian J; Ge, Wei; ChemistryThe crystal structure of an isopenicillin N synthase complex with an ethereal substrate analogue reveals water in the oxygen binding site, FEBS Letters, vol.587, 16, 2013,pp 2705-2709
2010The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthaseRutledge, Peter; Adlington, Robert M; Baldwin, Jack E; Clifton, Ian J; Ge, Wei; Stok, Jeanette E; ChemistryThe crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase, Organic and Biomolecular Chemistry, vol.8, 1, 2010,pp 122-127
2013The crystal structure of isopenicillin N synthase with a dipeptide substrate analogueRutledge, Peter; Adlington, Robert M; Baldwin, Jack E; Clifton, Ian J; Daruzzaman, Adam; ChemistryThe crystal structure of isopenicillin N synthase with a dipeptide substrate analogue, Archives of Biochemistry and Biophysics, vol.530, 1, 2013,pp 48-53
2011The crystal structure of isopenicillin N synthase with delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-methionine reveals thioether coordination to ironRutledge, Peter; Adlington, Robert M; Baldwin, Jack E; Clifton, Ian J; Ge, Wei; ChemistryThe crystal structure of isopenicillin N synthase with delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-methionine reveals thioether coordination to iron, Archives of Biochemistry and Biophysics, vol.516, 2, 2011,pp 103-107
2010Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthaseRutledge, Peter; Adlington, Robert M; Baldwin, Jack E; Clifton, Ian J; Ge, Wei; Stok, Jeanette E; ChemistryCrystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase, Biochemical and Biophysical Research Communications, vol.398, 4,pp 659-664
2007A cyclobutanone analogue mimics penicillin in binding to isopenicillin N synthaseRutledge, Peter; Adlington, Robert M; Baldwin, Jack E; Clifton, Ian J; Stewart, Amanda C; ChemistryA cyclobutanone analogue mimics penicillin in binding to isopenicillin N synthase, ChemBioChem: a European journal of chemical biology, vol.8,(16),2007,pp 2003-2007
2013The Interaction of Isopenicillin N Synthase with Homologated Substrate Analogues delta-(L-alpha-Aminoadipoyl)-L-homocysteinyl-D-Xaa Characterised by Protein CrystallographyRutledge, Peter; Adlington, Robert M; Baldwin, Jack E; Clifton, Ian J; Daruzzaman, Adam; ChemistryThe Interaction of Isopenicillin N Synthase with Homologated Substrate Analogues delta-(L-alpha-Aminoadipoyl)-L-homocysteinyl-D-Xaa Characterised by Protein Crystallography, ChemBioChem: a European journal of chemical biology, vol.14, 5, 2013,pp 599-606
2007Interactions of isopenicillin N synthase with cyclopropyl-containing substrate analogues reveal new mechanistic insightRutledge, Peter; Adlington, Robert M; Baldwin, Jack E; Clifton, Ian J; Elkins, Jonathan M; Howard-Jones, Annaleise R; Roach, Peter L; ChemistryInteractions of isopenicillin N synthase with cyclopropyl-containing substrate analogues reveal new mechanistic insight, Biochemistry, vol.46,(16),2007,pp 4755-4762
2008Isopenicillin N Synthase Mediates Thiolate Oxidation to Sulfenate in a Depsipeptide Substrate Analogue: Implications for Oxygen Binding and a Link to Nitrile Hydratase?Rutledge, Peter; Adlington, Robert M; Baldwin, Jack E; Clifton, Ian J; Ge, Wei; Stok, Jeanette E; ChemistryIsopenicillin N Synthase Mediates Thiolate Oxidation to Sulfenate in a Depsipeptide Substrate Analogue: Implications for Oxygen Binding and a Link to Nitrile Hydratase?, Journal of the American Chemical Society, vol.130, 31, 2008,pp 10096-10102
2009Structural studies on the reaction of isopenicillin N synthase with a sterically demanding depsipeptide substrate analogueRutledge, Peter; Adlington, Robert M; Baldwin, Jack E; Clifton, Ian J; Ge, Wei; Howard-Jones, Annaleise R; Stok, Jeanette E; ChemistryStructural studies on the reaction of isopenicillin N synthase with a sterically demanding depsipeptide substrate analogue, ChemBioChem: a European journal of chemical biology, vol.10,(12),2009,pp 2025-2031
2017Terminally truncated isopenicillin N synthase generates a dithioester product: Evidence for a thioaldehyde intermediate during catalysis and a new mode of reaction for non-heme iron oxidasesRutledge, Peter; Adlington, Robert M; Baldwin, Jack E; Brown, Toby J.N.; Burzlaff, Nicolai I.; Claridge, Timothy D. W.; Clifton, Ian J; McNeill, Luke A.; Sami, Malkit; Schofield, Christopher J; ChemistryTerminally truncated isopenicillin N synthase generates a dithioester product: Evidence for a thioaldehyde intermediate during catalysis and a new mode of reaction for non-heme iron oxidases, Chemistry - A European Journal, vol.23, 52, 2017,pp 12815-12824