Browsing by Author Christopoulos, Arthur

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Showing results 1 to 13 of 13
Issue DateTitleAuthor(s)Citation
2011Allosteric Modulation of the Calcium-sensing Receptor by y-Glutamyl Peptides Inhibition of PTH Secretion, Suppression of Intracellular cAMP Levels and A Common Mechanism of Action with L-Amino AcidsAvlani, Vimesh Ashvinkumar; Broadhead, Geoffrey; Church, William; Conigrave, Arthur; Delbridge, Leigh; Jourdon, Orane; Mun, Hee-Chang; Christopoulos, Arthur; Molecular Bioscience; Molecular Bioscience; Pharmacy; Molecular Bioscience; Northern Clinical School: Surgery; Molecular Bioscience; Molecular BioscienceAllosteric Modulation of the Calcium-sensing Receptor by y-Glutamyl Peptides Inhibition of PTH Secretion, Suppression of Intracellular cAMP Levels and A Common Mechanism of Action with L-Amino Acids, Journal of Biological Chemistry, vol.286, 11, 2011,pp 8786-8797
2015Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimeticsConigrave, Arthur; Christopoulos, Arthur; Cook, Anna; Furness, S G B; Gregory, K J; Leach, Katie; Mistry, S N; Scammells, Peter J.; Sexton, Patrick; Molecular BioscienceBiased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics, British Journal of Pharmacology, vol.172, 1, 2015,pp 185-200
2013Calcium-sensing receptor-dependent activation of CREB phosphorylation in HEK293 cells and human parathyroid cellsAvlani, Vimesh; Conigrave, Arthur; Delbridge, Leigh; Ma, Wenting; Mun, Hee-Chang; Christopoulos, Arthur; Leach, Katie; Molecular Bioscience; Molecular Bioscience; Northern Clinical School: Surgery; Molecular Bioscience; Molecular BioscienceCalcium-sensing receptor-dependent activation of CREB phosphorylation in HEK293 cells and human parathyroid cells, American Journal of Physiology: Endocrinology and Metabolism (Print), vol.304, 10, 2013,pp E1097-E1104
2012Design and receptor interactions of obligate dimeric mutant of chemokine monocyte chemoattractant protein-1 (MCP-1)Butler, Stephen; Payne, Richard; Taleski, Deni; Boston, Christopher; Canals, Meritxell; Carrick, Ann Marie; Christopoulos, Arthur; Ludeman, Justin; Parody, Todd R.; Stone, Martin; Tan, Joshua H.Y.; Wedderburn, Jamie; Chemistry; Chemistry; ChemistryDesign and receptor interactions of obligate dimeric mutant of chemokine monocyte chemoattractant protein-1 (MCP-1), Journal of Biological Chemistry, vol.287, 18, 2012,pp 14692-14702
2014Engendering biased signalling from the calcium-sensing receptor for the pharmacotherapy of diverse disordersConigrave, Arthur; Christopoulos, Arthur; Leach, K; Sexton, P M; Molecular BioscienceEngendering biased signalling from the calcium-sensing receptor for the pharmacotherapy of diverse disorders, British Journal of Pharmacology, vol.171, 5, 2014,pp 1142-1155
2013Impact of clinically relevant mutations on the pharmacoregulation and signaling bias of the calcium-sensing receptor by positive and negative allosteric modulatorsConigrave, Arthur; Christopoulos, Arthur; Cook, Anna; Leach, Katie; Sexton, Patrick M.; Wen, Adriel; Molecular BioscienceImpact of clinically relevant mutations on the pharmacoregulation and signaling bias of the calcium-sensing receptor by positive and negative allosteric modulators, Endocrinology, vol.154, 3, 2013,pp 1105-1116
2015A Positive Allosteric Modulator of the Adenosine A1 Receptor Selectively Inhibits Primary Afferent Synaptic Transmission in a Neuropathic Pain ModelBhola, Rebecca; Christie, MacDonald; Imlach, Wendy Louise; Christopoulos, Arthur; May, Lauren T.; School of Medical Sciences: Pharmacology; School of Medical Sciences: Pharmacology; School of Medical Sciences: PharmacologyA Positive Allosteric Modulator of the Adenosine A1 Receptor Selectively Inhibits Primary Afferent Synaptic Transmission in a Neuropathic Pain Model, Molecular Pharmacology, vol.88, 3, 2015,pp 460-468
2012Positive and Negative Allosteric Modulators Promote Biased Signaling at the Calcium-Sensing ReceptorConigrave, Arthur; Christopoulos, Arthur; Davey, Anna; Leach, Katie; Sexton, PM; Valant, Celine; Molecular BiosciencePositive and Negative Allosteric Modulators Promote Biased Signaling at the Calcium-Sensing Receptor, Endocrinology, vol.153, 3, 2012,pp 1232-1241
2015Receptor expression modulates calcium-sensing receptor mediated intracellular Ca2+ mobilizationBrennan, Sarah; Conigrave, Arthur; Kuchel, Philip; Mun, Hee-Chang; Christopoulos, Arthur; Leach, Katie; Molecular Bioscience; Molecular Bioscience; Molecular Bioscience; Molecular BioscienceReceptor expression modulates calcium-sensing receptor mediated intracellular Ca2+ mobilization, Endocrinology, vol.156, 4, 2015,pp 1330-1342
2014Roles of intraloops-2 and -3 and the proximal C-terminus in signalling pathway selection from the human calcium-sensing receptorAvlani, Vimesh Ashvinkumar; Conigrave, Arthur; Khan, Mahvash; Ward, James; Christopoulos, Arthur; Leach, Katie; Molecular Bioscience; Molecular Bioscience; Molecular Bioscience; Molecular BioscienceRoles of intraloops-2 and -3 and the proximal C-terminus in signalling pathway selection from the human calcium-sensing receptor, FEBS Letters, vol.588, 18, 2014,pp 3340-3346
2014Structural basis of receptor sulfotyprosine recognition by a CC chemokine: The N-terminal region of CCR3 bound to CCL11/eotaxin-1Payne, Richard; Bridgford, Jessica L.; Canals, Meritxell; Christopoulos, Arthur; Clayton, Daniel; Hinds, Mark G.; Ludeman, Justin; Millard, Christopher; Stone, Martin; ChemistryStructural basis of receptor sulfotyprosine recognition by a CC chemokine: The N-terminal region of CCR3 bound to CCL11/eotaxin-1, Structure, vol.22, 11, 2014,pp 1571-1581
2015Towards tissue-specific pharmacology: insights from the calcium-sensing receptor as a paradigm for GPCR (patho)physiological biasConigrave, Arthur; Christopoulos, Arthur; Leach, Katie; Sexton, Patrick; Molecular BioscienceTowards tissue-specific pharmacology: insights from the calcium-sensing receptor as a paradigm for GPCR (patho)physiological bias, Trends In Pharmacological Sciences, vol.36, 4, 2015,pp 215-225
2013Tyrosine Sulfation of Chemokine Receptor CCR2 Enhances Interactions with Both Monomeric and Dimeric Forms of the Chemokine Monocyte Chemoattractant Protein-1 (MCP-1)Butler, Stephen; Payne, Richard; Taleski, Deni; Canals, Meritxell; Christopoulos, Arthur; Hall, Pam; Hickey, Michael; Ludeman, Justin; Stone, Martin; Tan, Joshua H.Y.; Wedderburn, Jamie; Chemistry; Chemistry; ChemistryTyrosine Sulfation of Chemokine Receptor CCR2 Enhances Interactions with Both Monomeric and Dimeric Forms of the Chemokine Monocyte Chemoattractant Protein-1 (MCP-1), Journal of Biological Chemistry, vol.288, 14, 2013,pp 10024-10034