Browsing by Author Chircop (nee Fabbro), Megan

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Issue DateTitleAuthor(s)Citation
2017Automated classification and characterization of the mitotic spindle following knockdown of a mitosis-related proteinArthur, Jonathan; Chircop (nee Fabbro), Megan; Dean, Imraan M; Flores-Rodriguez, Neftali; Khushi, Matloob; Teber, Erdahl; Childrens Medical Research Institute (CMRI); Childrens Medical Research Institute (CMRI); Childrens Medical Research Institute (CMRI); Childrens Medical Research Institute (CMRI); Information Technologies; Childrens Medical Research Institute (CMRI)Automated classification and characterization of the mitotic spindle following knockdown of a mitosis-related protein, BMC Bioinformatics, vol.18, Suppl 16, 2017,pp 149-159
2008BARD1 regulates BRCA1-mediated transactivation of the p21WAF1/CIP1 and Gadd45 promotersChircop (nee Fabbro), Megan; Henderson, Beric; Children's Hospital Westmead: Childrens Medical Research Ins; Western Clinical School: Westmead Millennium InstituteBARD1 regulates BRCA1-mediated transactivation of the p21WAF1/CIP1 and Gadd45 promoters, Cancer Letters, vol.263, 2, 2008,pp 189-196
2013Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosisChau, Ngoc; Chircop (nee Fabbro), Megan; Daniel, James; Gorgani, Nick; Krishnan, Saieaswar; Lloyd, J; Mariana, Anna; Moshkanbaryans, Lia; Perera, Swetha; Quan, Annie; Robinson, Phillip; Whiting, Ainslie; Campbell, Michael; Clayton, Emma L.; Cousin, Michael A.; Deane, Fiona M; Hadzic, Gordana; Howes, Mark T.; McCluskey, Adam; McGeachie, Andrew; Meunier, Frederic; Nguyen, Tam; Parton, Robert G.; Robertson, Mark J; Sakoff, Jennette A.; Sun, Jian-Yuan; Von Kleist, Lisa; Xuefeng, Wang; Dean's Unit: CMRI; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; School of Medical Sciences: Bosch Institute; Western Clinical School: Medicine (Westmead); Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Dean's Unit: CMRI; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research InsBuilding a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis, Traffic (Malden), vol.14, 12, 2013,pp 1272-1289
2010Calcineurin activity is required for the completion of cytokinesisChircop (nee Fabbro), Megan; Lian, Audrey; Malladi, Chandra; Page, Scott; Robinson, Phillip; Zavortink, Michael; Gordon, Christopher; McCluskey, Adam; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research InsCalcineurin activity is required for the completion of cytokinesis, Cellular and Molecular Life Sciences, vol.67, 21,pp 3725-3737
2013CDC25B Overexpression Stabilises Centrin 2 and Promotes the Formation of Excess Centriolar FociChircop (nee Fabbro), Megan; Astuti, Puji; Boutros, Rose; Ducommun, Bernard; Gabrielli, B; Lorenzo, Corinne; McArthur, Grant A.; Mondesert, Odile; Children's Hospital Westmead: Childrens Medical Research InsCDC25B Overexpression Stabilises Centrin 2 and Promotes the Formation of Excess Centriolar Foci, PLoS One, vol.8, 7, 2013,pp 1-13
2015A Cholesterol-Dependent Endocytic Mechanism Generates Midbody Tubules During CytokinesisChircop (nee Fabbro), Megan; Kettle, Emma; Page, Scott; Robinson, Phillip; Wong, Chin; Boadle, Ross; Malladi, Chandra S; Marsh, Brad; Morgan, Garry; Childrens Medical Research Institute (CMRI); Childrens Medical Research Institute (CMRI); Children's Hospital Westmead: Childrens Medical Research Ins; Childrens Medical Research Institute (CMRI); Children's Hospital Westmead: Childrens Medical Research InsA Cholesterol-Dependent Endocytic Mechanism Generates Midbody Tubules During Cytokinesis, Traffic: the international journal of intracellular transport, vol.16, 11, 2015,pp 1174-1192
2016The clathrin-dependent spindle proteomeChircop (nee Fabbro), Megan; Flores-Rodriguez, Neftali; Page, Scott; Rao, Sushma R; Robinson, Phillip; Wong, Chin; Childrens Medical Research Institute (CMRI); Childrens Medical Research Institute (CMRI); Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Childrens Medical Research Institute (CMRI); Children's Hospital Westmead: Childrens Medical Research InsThe clathrin-dependent spindle proteome, Molecular and Cellular Proteomics, vol.15, 8, 2016,pp 2537-2553
2015Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2Akerfeldt, Mia; Chircop (nee Fabbro), Megan; Gurgis, Fadi; Munoz, Lenka; Wong, Chin; Adams, Seray; Guillemin, Gilles J.; Heng, Benjamin; Johns, Terrance G; Chemistry; Childrens Medical Research Institute (CMRI); School of Medical Sciences: Pharmacology; School of Medical Sciences: Pathology; Children's Hospital Westmead: Childrens Medical Research InsCytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2, Cell Death Discovery, vol.1, N/A, 2015,pp 1-11
2013Development of second-generation indole-based dynamin GTPase inhibitorsChau, Ngoc; Chircop (nee Fabbro), Megan; Mariana, Anna; Robinson, Phillip; Whiting, Ainslie; Gordon, Christopher; McCluskey, Adam; Robertson, Mark J; Venn-Brown, Barbara; Young, Kelly A.; Dean's Unit: CMRI; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research InsDevelopment of second-generation indole-based dynamin GTPase inhibitors, Journal of Medicinal Chemistry, vol.56, 1, 2013,pp 46-59
2011Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpressionBraithwaite, Antony; Chircop (nee Fabbro), Megan; Joshi, Sanket; Robinson, Phillip; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research InsDynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression, Molecular Cancer, vol.10, 78, 2011,pp 1-12
2010The Dynamin Inhibitors MiTMAB and OcTMAB Induce Cytokinesis Failure and Inhibit Cell Proliferation in Human Cancer CellsBraithwaite, Antony; Chircop (nee Fabbro), Megan; Joshi, Sanket; Mariana, Anna; Perera, Swetha; Robinson, Phillip; Smith, Charlotte; Gilbert, Jayne; Gordon, Christopher; McCluskey, Adam; Sarkoff, Jennette; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research InsThe Dynamin Inhibitors MiTMAB and OcTMAB Induce Cytokinesis Failure and Inhibit Cell Proliferation in Human Cancer Cells, Molecular Cancer Therapeutics, vol.9, 7,pp 1995-2006
2013Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cellsChircop (nee Fabbro), Megan; Robinson, Phillip; Smith, Charlotte; Haucke, Volker; McCluskey, Adam; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research InsInhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells, Molecular Cancer, vol.12, 4, 2013,pp 1-15
2011Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells.Chircop (nee Fabbro), Megan; Ma, Maggie; Mariana, Anna; Perera, Swetha; Robinson, Phillip; Gilbert, Jayne; Gordon, Christopher; Jones, Nigel C.; Lau, Hui; McCluskey, Adam; Morokoff, Andrew; O'Brien, T J; Sakoff, Jennette A.; Young, Kelly A.; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research InsInhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells., Molecular Cancer Therapeutics, vol.10, 9, 2011,pp 1553-1562
2015IQGAP1 is associated with nuclear envelope reformation and completion of abscissionChircop (nee Fabbro), Megan; Hains, Peter; Lian, Audrey; Robinson, Phillip; Sarcevic, Boris; Children's Hospital Westmead: Childrens Medical Research Ins; Central Clinical School: Save Sight & Eye Health Inst.; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research InsIQGAP1 is associated with nuclear envelope reformation and completion of abscission, Cell Cycle, vol.14, 3, 2015,pp 2058-2074
2016Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signallingChircop (nee Fabbro), Megan; Robinson, Phillip; Alserihi, R; Brown, Fiona; Chau, Ngoc; Chiu, S K; Collett, Michael; Curtis, David J; Jane, SM; Lucas, S E; McCormack, MP; Saw, J; Sonderegger, S E; Toribio, M L; Tremblay, C S; Childrens Medical Research Institute (CMRI); Childrens Medical Research Institute (CMRI)Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling, Leukemia, vol.30, 10, 2016,pp 1993-2001
2015Pharmacology of novel small-molecule tubulin inhibitors in glioblastoma cells with enhanced EGFR signallingAkerfeldt, Mia; Brown, Stephen; Chircop (nee Fabbro), Megan; Döbber, Alexander; Gurgis, Fadi; Kassiou, Michael; Munoz, Lenka; Phoa, Athena; Renn, Christian; Wong, Chin; Day, Bryan W.; Johns, Terrance G; Peifer, Christian; Stringer, Brett W.; Chemistry; School of Medical Sciences: Pharmacology; Childrens Medical Research Institute (CMRI); School of Medical Sciences: Pharmacology; School of Medical Sciences: Pharmacology; Medical Imaging and Radiation Sciences; School of Medical Sciences: Pathology; School of Medical Sciences: Pharmacology; School of Medical Sciences: Pharmacology; Children's Hospital Westmead: Childrens Medical Research InsPharmacology of novel small-molecule tubulin inhibitors in glioblastoma cells with enhanced EGFR signalling, Biochemical Pharmacology, vol.98, 4, 2015,pp 587-601
2011Phosphorylation of dynamin II at serine-764 is associated with cytokinesisAnggono, Victor; Chau, Ngoc; Chircop (nee Fabbro), Megan; Graham, Mark; Hains, Peter; Malladi, Chandra; Quan, Annie; Robinson, Phillip; Smith, Charlotte; Zavortink, Michael; Larsen, Martin R; Sarcevic, Boris; Children's Hospital Westmead: Childrens Medical Research Ins; Dean's Unit: CMRI; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Central Clinical School: Save Sight & Eye Health Inst.; Children's Hospital Westmead: Childrens Medical Research Ins; Dean's Unit: CMRI; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research InsPhosphorylation of dynamin II at serine-764 is associated with cytokinesis, B B A - Molecular Cell Research, vol.1813, 10, 2011,pp 1689-1699
2012Protein Phosphatases Drive Mitotic ExitChircop (nee Fabbro), Megan; Children's Hospital Westmead: Childrens Medical Research InsProtein Phosphatases Drive Mitotic Exit in Protein Kinases, InTech Publishers, 2012, pp. 215-228
2013Pyrimidyn Compounds: Dual-Action Small Molecule Pyrimidine-Based Dynamin InhibitorsChau, Ngoc; Chircop (nee Fabbro), Megan; Daniel, James; Gorgani, Nick; McGeachie, Andrew; Novelle, Aimee; Perera, Swetha; Quan, Annie; Robinson, Phillip; Whiting, Ainslie; Cousin, Michael A; Deane, Fiona M; Gilbert, Jayne; Hill, Timothy A.; Keating, Damien J; Mariana, Anna; McCluskey, Adam; Odell, Luke R; Sakoff, Jennette A.; van Dam, Ellen M; Young, Kelly A.; Dean's Unit: CMRI; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research Ins; Dean's Unit: CMRI; Children's Hospital Westmead: Childrens Medical Research Ins; Children's Hospital Westmead: Childrens Medical Research InsPyrimidyn Compounds: Dual-Action Small Molecule Pyrimidine-Based Dynamin Inhibitors, ACS Chemical Biology, vol.8, 7, 2013,pp 1507-1518
2003Regulation of tumor suppressors by nuclear-cytoplasmic shuttlingChircop (nee Fabbro), Megan; Henderson, Beric; Children's Hospital Westmead: Childrens Medical Research Ins; Western Clinical School: Westmead Millennium InstituteRegulation of tumor suppressors by nuclear-cytoplasmic shuttling, Experimental Cell Research: emphasizing molecular approaches to cell biology, vol.282,(2),2003,pp 59-69