Browsing by Author Alexander, Ian

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Issue DateTitleAuthor(s)Citation
2006AAV vectors encoding malarial antigens stimulate antigen-specific immunity but do not protect from parasite infection.Alexander, Ian; Coppel, Ross L.; Cunningham, Sharon C.; Logan, G; Wang, Lina; Zheng, Maolin; Children's Hospital Westmead: Paediatrics & Child HealthAAV vectors encoding malarial antigens stimulate antigen-specific immunity but do not protect from parasite infection., Vaccine, vol.25,(6),2006,pp 1014-1022
2013AAV-encoded OTC activity persisting to adulthood following delivery to newborn spfash mice is insufficient to prevent shRNA-induced hyperammonaemia.Alexander, Ian; Carpenter, Kevin; Cunningham, Sharon; Kok, Cindy; Spinoulas, Afroditi; Children's Hospital Westmead: Paediatrics & Child Health; Children's Hospital Westmead: Medicine; Children's Hospital Westmead: Childrens Medical Research InsAAV-encoded OTC activity persisting to adulthood following delivery to newborn spfash mice is insufficient to prevent shRNA-induced hyperammonaemia., Gene Therapy, vol.20, 12, 2013,pp 1184-1187
2009AAV2/8-mediated Correction of OTC Deficiency Is Robust in Adult but Not Neonatal Spf(ash) MiceAlexander, Ian; Carpenter, Kevin; Kuchel, Philip; Wilcken, Bridget; Cunningham, Sharon C.; Spinoulas, Afroditi; Children's Hospital Westmead: Paediatrics & Child Health; Children's Hospital Westmead: Medicine; School of Molecular Bioscience; Children's Hospital Westmead: Paediatrics & Child HealthAAV2/8-mediated Correction of OTC Deficiency Is Robust in Adult but Not Neonatal Spf(ash) Mice, Molecular Therapy, vol.17, 8,pp 1340-1346
2009Accepting risk in clinical research: is the gene therapy field becoming too risk-averse?Alexander, Ian; Deakin, Claire Tara; Kerridge, Ian; Children's Hospital Westmead: Paediatrics & Child Health; Law; School of Public Health: Ctr for Values Ethics & Law in MedAccepting risk in clinical research: is the gene therapy field becoming too risk-averse?, Molecular Therapy, vol.17, 11, 2009,pp 1842-1848
2015ACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in MiceAlexander, Ian; Habib, Miriam R; Sharland, Alexandra; Angus, Peter W; Chin, Ruth; Cunningham, Sharon C.; Herath, Chandana B.; Mak, Kai Y; Torresi, Joseph; Childrens Medical Research Institute (CMRI); Central Clinical School: Surgery; Central Clinical School: MedicineACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in Mice, Molecular Therapy, vol.23, 9, 2015,pp 1434-1443
2015Adeno-associated virus serotypes for gene therapeuticsAlexander, Ian; Lisowski, Leszek; Tay, Szun Szun; Childrens Medical Research Institute (CMRI)Adeno-associated virus serotypes for gene therapeutics, Current Opinion in Pharmacology, vol.24, N/A, 2015,pp 59-67
2013Adeno-associated Virus-mediated Rescue of Neonatal Lethality in Argininosuccinate Synthetase-deficient MiceAlexander, Ian; Carpenter, Kevin; Cunningham, Sharon; Kuchel, Philip; Dane, Alison; Kok, Cindy; Logan, G; Siew, Susan; Children's Hospital Westmead: Paediatrics & Child Health; Children's Hospital Westmead: Medicine; Children's Hospital Westmead: Childrens Medical Research Ins; Molecular BioscienceAdeno-associated Virus-mediated Rescue of Neonatal Lethality in Argininosuccinate Synthetase-deficient Mice, Molecular Therapy, vol.21, 10, 2013,pp 1823-1831
2010Antigen fusion with C3d(3) augments or inhibits humoral immunity to AAV genetic vaccines in a transgene-dependent manner.Alexander, Ian; Coppel, Ross L.; Logan, Grant J; Wang, Lina; Zheng, Maolin; Children's Hospital Westmead: Paediatrics & Child HealthAntigen fusion with C3d(3) augments or inhibits humoral immunity to AAV genetic vaccines in a transgene-dependent manner., Immunology and Cell Biology, vol.88, 2,pp 228-232
2009Antigen-specific humoral tolerance or immune augmentation induced by intramuscular delivery of adeno-associated viruses encoding CTLA4-Ig-antigen fusion moleculesAlexander, Ian; Coppel, Ross L.; Ginn, Samantha L; Logan, Grant J; Wang, L; Zheng, Maolin; Children's Hospital Westmead: Paediatrics & Child HealthAntigen-specific humoral tolerance or immune augmentation induced by intramuscular delivery of adeno-associated viruses encoding CTLA4-Ig-antigen fusion molecules, Gene Therapy, vol.16,(2),2009,pp 200-210
2008Bidirectional promoter interference between two widely used internal heterologous promoters in a late-generation lentiviral constructAlexander, Ian; Curtin, Julie; Dane, Alison; Ginn, Samantha L; Swanson, A; Children's Hospital Westmead: Paediatrics & Child Health; Children's Hospital Westmead: Paediatrics & Child HealthBidirectional promoter interference between two widely used internal heterologous promoters in a late-generation lentiviral construct, Gene Therapy (Basingstoke), vol.15,(5),2008,pp 384-390
2004C2C12 Co-Culture On A Fibroblast Substratum Enables Sustained Survival Of Contractile, Highly Differentiated Myotubes With Peripheral Nuclei And Adult Fast Myosin Expression.Alexander, Ian; Allen, David; Cooper, Sandra; Ghoddusi, M; Hardeman, Edna; Kizana, Eddy; Maxwell, Anthony; North, Kathryn; Children's Hospital Westmead: Paediatrics & Child Health; School of Medical Sciences: Physiology; Western Clinical School: Medicine (Westmead); Medicine; Children's Hospital Westmead: Childrens Medical Research Ins; Western Clinical School: Medicine (Westmead); FMO Security Patrol & Emergncy; Children's Hospital Westmead: Paediatrics & Child HealthC2C12 Co-Culture On A Fibroblast Substratum Enables Sustained Survival Of Contractile, Highly Differentiated Myotubes With Peripheral Nuclei And Adult Fast Myosin Expression., Cell Motility and the Cytoskeleton, vol.58,(3),2004,pp 200-211
2003Cardiac gene therapy: therapeutic potential and current progressAlexander, Ian; Kizana, Eddy; Children's Hospital Westmead: Paediatrics & Child HealthCardiac gene therapy: therapeutic potential and current progress, Current Gene Therapy: the international journal for in-depth reviews on gene therapy, vol.3,(5),2003,pp 418-451
2006Characterisation of a P140K mutant O(6)-methylguanine-DNA-methyltransferase (MGMT)-expressing transgenic mouse line with drug-selectable bone marrow.Alexander, Ian; Gunning, Peter; Kramer, B; Lemckert, Frances A.; McCowage, Geoffrey B.; Children's Hospital Westmead: Paediatrics & Child Health; Children's Hospital Westmead: Paediatrics & Child Health; Children's Hospital Westmead: Childrens Medical Research InsCharacterisation of a P140K mutant O(6)-methylguanine-DNA-methyltransferase (MGMT)-expressing transgenic mouse line with drug-selectable bone marrow., journal of gene medicine, vol.8,(9),2006,pp 1071-1085
2018Clinical Trial of MGMT(P140K) Gene Therapy in the Treatment of Pediatric Patients with Brain TumorsAlexander, Ian; Ching, Yu Wooi; Dent, Rebecca; Kramer, Belinda; McCowage, Geoffrey; Middlemiss, Shiloh; Rush, Amanda; Singh, Radhika; Wischusen, Jessica; Childrens Medical Research Institute (CMRI)Clinical Trial of MGMT(P140K) Gene Therapy in the Treatment of Pediatric Patients with Brain Tumors, Human Gene Therapy, vol.29, 8, 2018,pp 874-885
2018Clinical Trial of MGMT(P140K) Gene Therapy in the Treatment of Pediatric Patients with Brain TumorsAlexander, Ian; Ching, Yu Wooi; Dent, Rebecca; Kramer, Belinda; McCowage, Geoffrey; Middlemiss, Shiloh; Rush, Amanda; Singh, Radhika; Wischusen, Jessica; Childrens Medical Research Institute (CMRI)Clinical Trial of MGMT(P140K) Gene Therapy in the Treatment of Pediatric Patients with Brain Tumors, Human Gene Therapy, vol.29, 8, 2018,pp 874-885
2018Clinical Trial of MGMT(P140K) Gene Therapy in the Treatment of Pediatric Patients with Brain TumorsAlexander, Ian; Ching, Yu Wooi; Dent, Rebecca; Kramer, Belinda; McCowage, Geoffrey; Middlemiss, Shiloh; Rush, Amanda; Singh, Radhika; Wischusen, Jessica; Childrens Medical Research Institute (CMRI)Clinical Trial of MGMT(P140K) Gene Therapy in the Treatment of Pediatric Patients with Brain Tumors, Human Gene Therapy, vol.29, 8, 2018,pp 874-885
2018Clinical Trial of MGMT(P140K) Gene Therapy in the Treatment of Pediatric Patients with Brain TumorsAlexander, Ian; Ching, Yu Wooi; Dent, Rebecca; Kramer, Belinda; McCowage, Geoffrey; Middlemiss, Shiloh; Rush, Amanda; Singh, Radhika; Wischusen, Jessica; Childrens Medical Research Institute (CMRI)Clinical Trial of MGMT(P140K) Gene Therapy in the Treatment of Pediatric Patients with Brain Tumors, Human Gene Therapy, vol.29, 8, 2018,pp 874-885
2018Clinical Trial of MGMT(P140K) Gene Therapy in the Treatment of Pediatric Patients with Brain TumorsAlexander, Ian; Ching, Yu Wooi; Dent, Rebecca; Kramer, Belinda; McCowage, Geoffrey; Middlemiss, Shiloh; Rush, Amanda; Singh, Radhika; Wischusen, Jessica; Childrens Medical Research Institute (CMRI)Clinical Trial of MGMT(P140K) Gene Therapy in the Treatment of Pediatric Patients with Brain Tumors, Human Gene Therapy, vol.29, 8, 2018,pp 874-885
2015Coherence analysis discriminates between retroviral integration patterns in CD34(+) cells transduced under differing clinical trial conditionsAlexander, Ian; Ginn, Samantha; Liddle, Christopher; et al, Various; Garg, Gagan; Hallwirth, Claus V.; Hetherington, Nicola; Hyman, Jessica; Kramer, Belinda; Malani, Nirav V; Peters, Timothy J; Ruan, Xiaoan; Shahab, Atif; Veeravalli, Lavanya; Childrens Medical Research Institute (CMRI); Childrens Medical Research Institute (CMRI); Western Clinical School: Medicine (Westmead)Coherence analysis discriminates between retroviral integration patterns in CD34(+) cells transduced under differing clinical trial conditions, Molecular Therapy - Methods & Clinical Development, vol.2, N/A, 2015,pp 1-10
2013Comparison of gene transfer to the murine liver following intraperitoneal and intraportal delivery of hepatotropic AAV pseudo-serotypesAlexander, Ian; Cunningham, Sharon; Dane, Alison; Wowro, S; Children's Hospital Westmead: Paediatrics & Child Health; Children's Hospital Westmead: Childrens Medical Research InsComparison of gene transfer to the murine liver following intraperitoneal and intraportal delivery of hepatotropic AAV pseudo-serotypes, Gene Therapy, vol.20, 4, 2013,pp 460-464