Browsing by Author Absalom, Nathan

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Issue DateTitleAuthor(s)Citation
2012(alpha)4(beta)(delta) GABAA receptors are high-affinity targets for gamma-hydroxybutyric acid (GHB)Absalom, Nathan; Collins (Chebib), Mary; Karim, Nasiara; Bay, Tina; Brauner-Osborne, Hans; Clausen, Rasmus; Eghorn, Laura; Frolund, Bente; Knudsen, Gitte; Olsen, Jesper; Villumsen, Inge; Wellendorph, Petrine; Pharmacy; Pharmacy; Pharmacy(alpha)4(beta)(delta) GABAA receptors are high-affinity targets for gamma-hydroxybutyric acid (GHB), Proceedings of the National Academy of Sciences (PNAS), vol.109, 33, 2012,pp 13404-13409
2012Covalent attachment of antagonists to the a7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimidesAbsalom, Nathan; Collins (Chebib), Mary; Ambrus, Joseph; Balle, Thomas; Halliday, Jill; Harpsoe, Kasper; Kanizaj, Nicholas; McLeod, Malcolm; Pharmacy; PharmacyCovalent attachment of antagonists to the a7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides, Chemical Communications, vol.48, 53, 2012,pp 6699-6701
2013Covalent trapping of methyllycaconitine at the alpha4-alpha4 interface of the apha4beta2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealedAbsalom, Nathan; Balle, Thomas; Collins (Chebib), Mary; Karim, Nasiara; Qudah, Taima; Quek, Gracia; von Arenstorff, Ida; Ambrus, Joseph; Harpsøe, Kasper; Lewis, Trevor M.; McLeod, Malcolm; Pharmacy; Pharmacy; Pharmacy; Pharmacy; Pharmacy; Pharmacy; PharmacyCovalent trapping of methyllycaconitine at the alpha4-alpha4 interface of the apha4beta2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed, The Journal of Biological Chemistry, vol.288, 37, 2013,pp 26521-26532
2010Identifying the Binding Site of Novel Methyllycaconitine (MLA) Analogs at α4β2 Nicotinic Acetylcholine ReceptorsAbsalom, Nathan; Collins (Chebib), Mary; Lin, Diana; Quek, Gracia; Ambrus, Joseph; Halliday, Jill; Lochner, Martin; Lummis, Sarah; McLeod, Malcolm; Thompson, Andrew; Pharmacy; Pharmacy; Pharmacy; PharmacyIdentifying the Binding Site of Novel Methyllycaconitine (MLA) Analogs at α4β2 Nicotinic Acetylcholine Receptors, ACS Chemical Neuroscience, vol.1, 12,pp 796-809
2012Low nanomolar GABA effects at extrasynaptic a4b1/b3d GABAA receptor subtypes indicate a different binding mode for GABA at these receptorsAbsalom, Nathan; Collins (Chebib), Mary; Hanrahan, Jane; Hansen, Maja; Johnston, Graham; Karim, Nasiara; Lee, Ho Joon; Bang, Line; Jensen, Marianne Lerbech; Wellendorph, Petrine; Pharmacy; Pharmacy; Pharmacy; Pharmacy; School of Medical Sciences: Pharmacology; Pharmacy; PharmacyLow nanomolar GABA effects at extrasynaptic a4b1/b3d GABAA receptor subtypes indicate a different binding mode for GABA at these receptors, Biochemical Pharmacology, vol.84, 4, 2012,pp 549-557
2011Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-QAbsalom, Nathan; Chebib, Mary; Hanrahan, Jane; Heblinski, Marika; Johnston, Graham; Pera, Elena; Yow, Tin; Pharmacy; Pharmacy; Pharmacy; Northern Clinical School: Medicine; School of Medical Sciences: Pharmacology; Pharmacy; PharmacyNaringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q, British Journal of Pharmacology, vol.163, 5, 2011,pp 1017-1033
2013Potency of gaba at human recombinant gaba alpha receptors expressed in xenopus oocytes: a mini reviewAbsalom, Nathan; Collins (Chebib), Mary; Hanrahan, Jane; Johnston, Graham; Karim, Nasiara; Wellendorph, Petrine; Pharmacy; Pharmacy; Pharmacy; School of Medical Sciences: Pharmacology; PharmacyPotency of gaba at human recombinant gaba alpha receptors expressed in xenopus oocytes: a mini review, Amino Acids, vol.44, 4, 2013,pp 1139-1149
2012Structurally Diverse GABA Antagonists Interact Differently with Open and Closed Conformational States of the p1 ReceptorAbsalom, Nathan; Allan, Robin; Carland, Jane; Collins (Chebib), Mary; Gavande, Navnath; Hanrahan, Jane; Johnston, Graham; Locock, Katherine; Yamamoto, Izumi; Pharmacy; School of Medical Sciences: Pharmacology; Pharmacy; Pharmacy; Pharmacy; Pharmacy; School of Medical Sciences: Pharmacology; School of Medical Sciences: Pharmacology; PharmacyStructurally Diverse GABA Antagonists Interact Differently with Open and Closed Conformational States of the p1 Receptor, ACS Chemical Neuroscience, vol.3, 4, 2012,pp 293-301