Browsing by Author West, Nicholas

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Issue DateTitleAuthor(s)Citation
2017Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesisBritton, Warwick; Conroy, Trent; Dowman, Luke J.; Giltrap, Andrew Michael; Pang, Angel; Payne, Richard; Tran, Anh Thu Eve; Watson, Emma; Bugg, Timothy D.H.; Charman, Susan; Crick, Dean; Dowson, Christopher; Linington, Roger G.; Mahapatra, Sebabrata; Pujari, Venugopal; Roper, David; Saunders, Jessica; Tod, Julie; West, Nicholas; Wong, Weng Ruh; Central Clinical School: Centenary Institute; Chemistry; Chemistry; Chemistry; Central Clinical School: Centenary Institute; Chemistry; Chemistry; ChemistrySansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis, Nature Communications, vol.8, N/A, 2017,pp 1-9
2012The Secreted Lipoprotein, MPT83, of Mycobacterium tuberculosis Is Recognized during Human Tuberculosis and Stimulates Protective Immunity in MiceBritton, Warwick; Pinto, Rachael; Triccas, James; Kao, Fan; Mahmuda, Sultana; West, Nicholas; Central Clinical School: Centenary Institute; Central Clinical School: Medicine; Central Clinical School: MedicineThe Secreted Lipoprotein, MPT83, of Mycobacterium tuberculosis Is Recognized during Human Tuberculosis and Stimulates Protective Immunity in Mice, PLoS One, vol.7, 5, 2012,pp 1-12
2012Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active siteBritton, Warwick; Cergol, Katie; Manos-Turvey, Alexandra; Pang, Angel; Payne, Richard; Salam, Noeris; West, Nicholas; Baker, Edward; Bulloch, Esther; Chi, Gamma; Lott, J. Shaun; Central Clinical School: Centenary Institute; Chemistry; Chemistry; Central Clinical School: Centenary Institute; Chemistry; Pharmacy; Central Clinical School: Centenary InstituteSynthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site, Organic and Biomolecular Chemistry, vol.10, 46, 2012,pp 9223-9236
2011Synthesis and Evaluation of Potent Ene-yne inhibitors of type II Dehydroquinases as Tuberculosis Drug LeadsBritton, Warwick; Cergol, Katie; Payne, Richard; Randall, Elizabeth; Tran, Anh; West, Nicholas; Bokhari, Syed Ali Imran; Ibrahim, Musadiq; Lapthorn, Adrian J.; Central Clinical School: Centenary Institute; Chemistry; Chemistry; Central Clinical School: Centenary Institute; Chemistry; Central Clinical School: Centenary InstituteSynthesis and Evaluation of Potent Ene-yne inhibitors of type II Dehydroquinases as Tuberculosis Drug Leads, ChemMedChem: chemistry enabling drug discovery, vol.6, 2, 2011,pp 262-265
2010Tetrahydrolipstatin inhibition, functional analyses, and three-dimensional structure of a lipase essential for mycobacterial viabilityBritton, Warwick; West, Nicholas; Brammananth, Rajini; Chow, Francess M E; Crellin, Paul; et al, various; Le Nours, Jerome; Proellocks, Nicholas; Scoble, Judith; Shahine, Adam; Vivian, J P; Wilce, Matthew C. J.; Central Clinical School: Centenary Institute; Central Clinical School: Centenary InstituteTetrahydrolipstatin inhibition, functional analyses, and three-dimensional structure of a lipase essential for mycobacterial viability, Journal of Biological Chemistry, vol.285, 39,pp 30050-30060
2013TLR2-targeted secreted proteins from Mycobacterium tuberculosis are protective as powdered pulmonary vaccinesBritton, Warwick; Chan, Hak-Kim (Kim); Chan, John Gar Yan; Atmosukarto, Ines; Shanahan, Erin; Tyne, Anneliese; West, Nicholas; Central Clinical School: Centenary Institute; Pharmacy; PharmacyTLR2-targeted secreted proteins from Mycobacterium tuberculosis are protective as powdered pulmonary vaccines, Vaccine, vol.31, 40, 2013,pp 4322-4329