Browsing by Author O'Toole, Sandra

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Issue DateTitleAuthor(s)Citation
2014EGFR mutation specific immunohistochemistry is a useful adjunct which helps to identify false negative mutation testing in lung cancerCooper, Wendy Anne; Gill, Anthony; Houang, Michelle; O'Toole, Sandra; Pavlakis, Nick; Raut, Aditi; Toon, Christopher Chien; Chou, Angela; Clarkson, Adele; Mahtab, Farzin; Mead, Scott; Sioson, Loretta; Watson, Nicole; Central Clinical School: Medicine; Northern Clinical School: Pathology; Northern Clinical School: Kolling Institute; Central Clinical School: Pathology; Northern Clinical School: Medicine; Medicine; Northern Clinical School: Kolling InstituteEGFR mutation specific immunohistochemistry is a useful adjunct which helps to identify false negative mutation testing in lung cancer, Pathology, vol.46, 6, 2014,pp 501-508
2015ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor CellsNaylor, Matthew; O'Toole, Sandra; Allerdice, Stephanie; Cho, Christina; et al, Various; Gallego-Ortega, David; Kikhtyak, Zoya; Law, Andrew M K; Ledger, Anita; Lee, Heather; Magenau, Astrid; Roden, Daniel; Valdes-Mora, Fatima; School of Medical Sciences: Physiology; Central Clinical School: PathologyELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells, PLoS Biology, vol.13, 12, 2015,pp 1-27
2011Enhanced RAD21 cohesin expression confers poor prognosis and resistance to chemotherapy in high grade luminal, basal and HER2 breast cancersMcNeil, Catriona; O'Toole, Sandra; Fox, Stephen B.; McKay, Michael J.; Millar, Ewan; Natrajan, Rachael; Patra, Jennifer; Ramsay, Robert G.; Reis-Filho, Jorge; Sutherland, Robert L.; Swagemakers, Sigrid; Tomaszewski, Jonathan M.; van der Spek, Peter; Verschoor, Sandra; Xu, Huiling; Yan, Max; Yan, Yuqian; Western Clinical School: Medicine (Westmead); Central Clinical School: PathologyEnhanced RAD21 cohesin expression confers poor prognosis and resistance to chemotherapy in high grade luminal, basal and HER2 breast cancers, Breast Cancer Research, vol.13, 1, 2011,pp R9-1-R9-36
2015Equivocal ALK fluorescence in-situ hybridization (FISH) cases may benefit from ancillary ALK FISH probe testingCooper, Wendy Anne; Gill, Anthony; Pavlakis, Nick; Amanuel, Benhur; Christie, Michael; Diakos, Connie; Lum, Trina; McNeil, Catriona; Millward, Michael; Morey, Adrienne; O'Toole, Sandra; Peverall, Joanne; Selinger, Christina; Tran, Yen; Van Vliet, Chris; Waring, Paul; Central Clinical School: Medicine; Northern Clinical School: Pathology; Northern Clinical School: MedicineEquivocal ALK fluorescence in-situ hybridization (FISH) cases may benefit from ancillary ALK FISH probe testing, Histopathology, vol.67, 5, 2015,pp 654-663
2013Fibroblast growth factor receptor 1 (FGFR1) copy number is an independent prognostic factor in non-small cell lung cancerMcCaughan, Brian; O'Toole, Sandra; Cooper, Wendy; Kennedy, Catherine; Kohonen-Corish, Maija R.J.; Selinger, Christina; Tran, Thang N.; Central Clinical School: Surgery; Central Clinical School: PathologyFibroblast growth factor receptor 1 (FGFR1) copy number is an independent prognostic factor in non-small cell lung cancer, Lung Cancer, vol.81, 3, 2013,pp 462-467
2011Hedgehog Overexpression Is Associated with Stromal Interactions and Predicts for Poor Outcome in Breast CancerCooper, Caroline; O'Toole, Sandra; Christ, Daniel; Hannigan, Gregory E.; Machalek, Dorothy A.; Martelotto, Luciano G.; McFarland, Andrea; McLeod, Duncan; McNeil, Catriona M.; Millar, Ewan; Musgrove, Elizabeth A.; Nair, Radhika; Nguyen, Akira; Ormandy, Christopher J.; Qiu, Min Ru; Rabinovich, Brian; Schofield, Peter R.; Shearer, Robert F.; Sutherland, Robert L.; Swarbrick, A.; Vu, Duc; Watkins, D. Neil; Central Clinical School: Pathology; Central Clinical School: PathologyHedgehog Overexpression Is Associated with Stromal Interactions and Predicts for Poor Outcome in Breast Cancer, Cancer Research, vol.71, 11, 2011,pp 4002-4014
2009The Hedgehog signalling pathway as a therapeutic target in early breast cancer development.O'Toole, Sandra; Sutherland, Robert L.; Swarbrick, A.; Central Clinical School: PathologyThe Hedgehog signalling pathway as a therapeutic target in early breast cancer development., Expert Opinion on Therapeutic Targets, vol.13, 9,pp 1095-1103
2013The Hedgehog signalling pathway in breast development, carcinogenesis and cancer therapyO'Toole, Sandra; Cazet, Aurelie; Hui, Mun; Nair, Radhika; Swarbrick, A.; Watkins, D. Neil; Central Clinical School: PathologyThe Hedgehog signalling pathway in breast development, carcinogenesis and cancer therapy, Breast Cancer Research, vol.15, 2, 2013,pp 1-14
2015HER2 insertion YVMA mutant lung cancer: Long natural history and response to afatinibCooper, Wendy Anne; Lee, Adrian; Li, B T; O'Toole, Sandra; Pavlakis, Nick; Yu, Bing; Arcila, Maria E; Chaft, Janie E; Kris, Mark G; Central Clinical School: Medicine; Northern Clinical School: Medicine; Central Clinical School: Pathology; Central Clinical School: Pathology; Northern Clinical School: Medicine; Central Clinical School: MedicineHER2 insertion YVMA mutant lung cancer: Long natural history and response to afatinib, Lung Cancer, vol.90, 3, 2015,pp 617-619
2010High Notch1 protein expression is an early event in breast cancer development and is associated with the HER-2 molecular subtypeHamilton, Anne; Lee, Cheok; McNeil, Catriona; Spillane, Andrew; Crea, P; Lopez-Knowles, Elena; McLeod, Duncan; Millar, Ewan; Morey, Adrienne; Murphy, N C; Musgrove, Elizabeth A.; Oakes, Samantha; Ormandy, Christopher J.; O'Toole, Sandra; Pinese, Mark; Qiu, Min; Sutherland, Robert L.; Zardawi, Ibrahim; Zardawi, Sarah J; Central Clinical School: Medicine; Central Clinical School: Medicine; Western Clinical School: Medicine (Westmead); Northern Clinical School: MedicineHigh Notch1 protein expression is an early event in breast cancer development and is associated with the HER-2 molecular subtype, Histopathology, vol.56, 3,pp 286-296
2015ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotypeNaylor, Matthew; O'Toole, Sandra; Baker, Laura; Cazet, Aurelie; Elsworh, Ben; et al, Various; Gallego-Ortega, David; Junankar, Simon; Lacaze, Paul; Nair, Radhika; Nikolic, Iva; Roden, Daniel; Teo, W S; School of Medical Sciences: Physiology; Central Clinical School: PathologyID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype, Nature Communications, vol.6, N/A, 2015,pp 1-12
2011Identification of PUMA as an estrogen target gene that mediates the apoptotic response to tamoxifen in human breast cancer cells and predicts patient outcome and tamoxifen responsiveness in breast cancerMcNeil, Catriona; O'Toole, Sandra; Butt, Alison Joy; Lehrbach, Gillian M.; McCloy, R. A.; Millar, E. K. A.; Musgrove, Elizabeth A.; Pinese, Mark; Roberts, C. G.; Sutherland, Robert L.; Tobelmann, P; Western Clinical School: Medicine (Westmead); Central Clinical School: PathologyIdentification of PUMA as an estrogen target gene that mediates the apoptotic response to tamoxifen in human breast cancer cells and predicts patient outcome and tamoxifen responsiveness in breast cancer, Oncogene: including Oncogene Reviews, vol.30, 28, 2011,pp 3186-3197
2014Intrapatient Homogeneity of BRAFV600E Expression in MelanomaHyman, Jessica; Kefford, Richard (Rick); Long, Georgina; Menzies, Alexander Maxwel; O'Toole, Sandra; Scolyer, Richard; Thompson, John; Wilmott, James; Lum, Trina; Melanoma Foundation; Western Clinical School: Westmead Millennium Institute; Central Clinical School: The Sydney Cancer Centre; Central Clinical School: Medicine; Central Clinical School: Pathology; Central Clinical School: Pathology; Central Clinical School: Surgery; Central Clinical School: SurgeryIntrapatient Homogeneity of BRAFV600E Expression in Melanoma, The American Journal of Surgical Pathology, vol.38, 3, 2014,pp 377-382
2010Loss of STARD10 expression identifies a group of poor prognosis breast cancers independent of HER2/Neu and triple negative statusMcNeil, Catriona; O'Toole, Sandra; Biankin, Andrew V.; Crea, Paul; et al, various; Fox, Stephen B.; Lee, Cheok; Millar, E.; Murphy, Niamh; Olayioye, Monilola; Segara, Davendra; Western Clinical School: Medicine (Westmead); Central Clinical School: PathologyLoss of STARD10 expression identifies a group of poor prognosis breast cancers independent of HER2/Neu and triple negative status, International Journal of Cancer, vol.126, 6,pp 1445-1453
2017LRH-1 expression patterns in breast cancer tissues are associated with tumour aggressivenessLee, Cheok; O'Toole, Sandra; Byrne, David; Chand, Ashwini; Clyne, C; et al, Various; Knower, Kevin; Mikeska, Thomas; Millar, E. K. A.; Molania, Ramyar; Pang, Jia-Min B.; Takano, E; Central Clinical School: Medicine; Central Clinical School: PathologyLRH-1 expression patterns in breast cancer tissues are associated with tumour aggressiveness, Oncotarget, vol.8, 48, 2017,pp 83626-83636
2015Mammary analogue secretory carcinoma: an evaluation of its clinicopathological and genetic characteristicsClark, Jonathan; Gupta, Ruta; O'Toole, Sandra; Yu, Bing; Eviston, Timothy J; Luk, Peter; Lum, Trina; Selinger, Christina; Central Clinical School: Surgery; School of Medical Sciences: Pathology; Central Clinical School: Pathology; Central Clinical School: MedicineMammary analogue secretory carcinoma: an evaluation of its clinicopathological and genetic characteristics, Pathology, vol.47, 7, 2015,pp 659-666
2017Massive parallel sequencing of solid tumours - challenges and opportunities for pathologistsO'Toole, Sandra; Browett, Peter; George, Peter; Harris, Gavin; Print, Cristin; Central Clinical School: PathologyMassive parallel sequencing of solid tumours - challenges and opportunities for pathologists, Histopathology, vol.70, N/A, 2017,pp 123-133
2016MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinibO'Toole, Sandra; Brummer, Tilman; Castillo, Lesley; Chong, Sabrina; Cullen, Hayley D.; et al, Various; Herzog, Sebastian; Koehler, Martin; Law, Andrew M K; Lee, Erinna F.; Young, Adelaide; Central Clinical School: PathologyMCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib, Breast Cancer Research, vol.18, 1, 2016,pp 1-15
2015MicroRNA profiling of the pubertal mouse mammary gland identifies miR-184 as a candidate breast tumour suppressor geneJames, David; O'Toole, Sandra; Deng, Niantao; Elsworth, Benjamin; et al, Various; Kaplan, Warren; McFarland, Andrea; Nguyen, Akira; Nikolic, Iva; Phua, Yuwei; Roden, Daniel; Russell, Roslin; Yang, Jessica; Molecular Bioscience; Central Clinical School: PathologyMicroRNA profiling of the pubertal mouse mammary gland identifies miR-184 as a candidate breast tumour suppressor gene, Breast Cancer Research, vol.17, 1, 2015,pp 1-18
2015MicroRNA-Related DNA repair/ cell-cycle genes independently associated with relapse after radiation therapy for early breast cancerBeith, Jane; Carmalt, Hugh; Cooper, Caroline; Gee, Harriet; Kennedy, Catherine Jane; McNeil, Catriona; O'Toole, Sandra; Beckers, Rhiannon; Buffa, Francesca; Carroll, Susan L; et al, Various; Harris, Adrian L.; Holliday, Anne; Mak, Cindy; Selinger, Christina; Toohey, Joanne; Warrier, Sanjay; Central Clinical School: Medicine; Concord Clinical School: Surgery; Central Clinical School: Pathology; Central Clinical School: Medicine; Western Clinical School: Medicine (Westmead); Western Clinical School: Medicine (Westmead); Central Clinical School: PathologyMicroRNA-Related DNA repair/ cell-cycle genes independently associated with relapse after radiation therapy for early breast cancer, International Journal of Radiation Oncology: Biology Physics, vol.93, 5, 2015,pp 1104-1114