Browsing by Author Munoz, Lenka

Jump to: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
or enter first few letters:  
Showing results 1 to 17 of 17
Issue DateTitleAuthor(s)Citation
2013The 3,7-diazabicylo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor ligands. Part 2: Carboxamide derivatives with different spacer motifsMunoz, Lenka; Eibl, Christoph; Gundisch, Daniela; Papke, Roger; Stokes, Clare; Tomassoli, Isabelle; School of Medical Sciences: PharmacologyThe 3,7-diazabicylo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor ligands. Part 2: Carboxamide derivatives with different spacer motifs, Bioorganic and Medicinal Chemistry, vol.21, 23, 2013,pp 7309-7329
2015Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2Akerfeldt, Mia; Chircop (nee Fabbro), Megan; Gurgis, Fadi; Munoz, Lenka; Wong, Chin; Adams, Seray; Guillemin, Gilles J.; Heng, Benjamin; Johns, Terrance G; Chemistry; Childrens Medical Research Institute (CMRI); School of Medical Sciences: Pharmacology; School of Medical Sciences: Pathology; Children's Hospital Westmead: Childrens Medical Research InsCytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2, Cell Death Discovery, vol.1, N/A, 2015,pp 1-11
2015Design, Synthesis, and Biological Evaluation of Tetra-Substituted Thiophenes as Inhibitors of p38α MAPKMunoz, Lenka; Ryan, Renae; Chalmers, David; Devine, Shane; Krum, Henry; Scammells, Peter J.; Simpson, Jamie; Vinh, Natalie; Wang, Bing; School of Medical Sciences: Pharmacology; School of Medical Sciences: PharmacologyDesign, Synthesis, and Biological Evaluation of Tetra-Substituted Thiophenes as Inhibitors of p38α MAPK, ChemistryOpen, vol.4, 1, 2015,pp 56-64
2017Development and Biological Evaluation of a Photoactivatable Small Molecule Microtubule-Targeting AgentAbbassi, Ramzi; Dobber, Alexander; Munoz, Lenka; Phoa, Athena; Abadleh, M; Day, Bryan W.; Johns, Terrance G; Peifer, C; Stringer, Brett W.; School of Medical Sciences: Pharmacology; School of Medical Sciences: School of Medical Sciences; School of Medical Sciences: Pathology; School of Medical Sciences: PharmacologyDevelopment and Biological Evaluation of a Photoactivatable Small Molecule Microtubule-Targeting Agent, ACS Medicinal Chemistry Letters, vol.8, 4, 2017,pp 395-400
2017Discovery and pharmacological evaluation of a novel series of adamantyl cyanoguanidines as P2X7 receptor antagonistsBarron, Melissa; Jackson, Alexander; Kassiou, Michael; McDonnell, Michelle; Munoz, Lenka; O'Brien-Brown, James; Reekie, Tristan Andrew; Schiavini, Paolo; Werry, Eryn; Wilkinson, Shane; Noll, Benjamin D.; Wang, Shudong; School of Medical Sciences: Physiology; Research Grants and Contracts; Chemistry; School of Medical Sciences: Pharmacology; School of Medical Sciences: Pathology; Chemistry; Medical Imaging and Radiation Sciences; Chemistry; Medical Imaging and Radiation Sciences; ChemistryDiscovery and pharmacological evaluation of a novel series of adamantyl cyanoguanidines as P2X7 receptor antagonists, European Journal of Medicinal Chemistry, vol.130, N/A, 2017,pp 433-439
2015DYRK1A in neurodegeneration and cancer: Molecular basis and clinical implicationsAbbassi, Ramzi; Kassiou, Michael; Munoz, Lenka; Johns, Terrance G; School of Medical Sciences: Pharmacology; Medical Imaging and Radiation Sciences; School of Medical Sciences: PharmacologyDYRK1A in neurodegeneration and cancer: Molecular basis and clinical implications, Pharmacology & Therapeutics, vol.151, N/A, 2015,pp 87-98
2017Kinase targets in CNS drug discoveryKassiou, Michael; Munoz, Lenka; Gunosewoyo, Hendra; Yu, Lifang; Chemistry; School of Medical Sciences: PathologyKinase targets in CNS drug discovery, Future Medicinal Chemistry, vol.9, 3, 2017,pp 303-314
2014Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Neuroinflammation, Heat Shock Protein 27 Phosphorylation and Cell Cycle: Role and TargetingGurgis, Fadi; Munoz, Lenka; Ziaziaris, William; School of Medical Sciences: Pharmacology; School of Medical Sciences: Pharmacology; Western Clinical School: Medicine (Westmead)Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Neuroinflammation, Heat Shock Protein 27 Phosphorylation and Cell Cycle: Role and Targeting, Molecular Pharmacology, vol.85, 2, 2014,pp 345-356
2017Non-kinase targets of protein kinase inhibitorsMunoz, Lenka; School of Medical Sciences: PathologyNon-kinase targets of protein kinase inhibitors, Nature Reviews. Drug Discovery, vol.16, N/A, 2017,pp 424-440
2010Novel p38 MAPK inhibitor ML3403 has potent anti-inflammatory activity in airway smooth muscleAmmit, Alaina; Ge, Qi; Manetsch, Melanie; Munoz, Lenka; Ramsay, Emma; Laufer, Stefan; Peifer, Christian; Pharmacy; School of Medical Sciences: Pharmacology; Pharmacy; School of Medical Sciences: Pharmacology; PharmacyNovel p38 MAPK inhibitor ML3403 has potent anti-inflammatory activity in airway smooth muscle, European Journal of Pharmacology, vol.635, N/A, 2010,pp 212-218
2016Oncogenic Ras modulates p38 MAPK-mediated inflammatory cytokine production in glioblastoma cellsGrewal, Thomas; Munoz, Lenka; Yeung, Yiu To Otto; Pharmacy; School of Medical Sciences: Pathology; School of Medical Sciences: PharmacologyOncogenic Ras modulates p38 MAPK-mediated inflammatory cytokine production in glioblastoma cells, Cancer Biology and Therapy, vol.17, 4, 2016,pp 355-363
2015Optimisation of LRRK2 inhibitors and assessment of functional efficacy in cell-based models of neuroinflammationChen, Ew-Jun; Doddareddy, Munikumar; Kassiou, Michael; Kavanagh, Madeline; Munoz, Lenka; Phoa, Athena; Dzamko, Nicolas; Guillemin, Gilles J.; Heng, Benjamin; Not known; School of Medical Sciences: Brain & Mind Research Institute; Medical Imaging and Radiation Sciences; Chemistry; School of Medical Sciences: Pharmacology; School of Medical Sciences: PharmacologyOptimisation of LRRK2 inhibitors and assessment of functional efficacy in cell-based models of neuroinflammation, European Journal of Medicinal Chemistry, vol.95, N/A, 2015,pp 29-34
2015The p38-MK2-HuR pathway potentiates EGFRvIII-IL-1β-driven IL-6 secretion in glioblastoma cellsAmmit, Alaina; Buckland, Michael; Grewal, Thomas; Gurgis, Fadi; Munoz, Lenka; Tang, M X M; Yeung, Yiu To Otto; Guillemin, Giles; Haapasalo, H; Haapasalo, J; Heng, Benjamin; Pharmacy; School of Medical Sciences: Brain and Mind Centre; Pharmacy; School of Medical Sciences: Pharmacology; School of Medical Sciences: Pathology; Pharmacy; School of Medical Sciences: PharmacologyThe p38-MK2-HuR pathway potentiates EGFRvIII-IL-1β-driven IL-6 secretion in glioblastoma cells, Oncogene, vol.34, 22, 2015,pp 2934-2942
2015Pharmacology of novel small-molecule tubulin inhibitors in glioblastoma cells with enhanced EGFR signallingAkerfeldt, Mia; Brown, Stephen; Chircop (nee Fabbro), Megan; Döbber, Alexander; Gurgis, Fadi; Kassiou, Michael; Munoz, Lenka; Phoa, Athena; Renn, Christian; Wong, Chin; Day, Bryan W.; Johns, Terrance G; Peifer, Christian; Stringer, Brett W.; Chemistry; School of Medical Sciences: Pharmacology; Childrens Medical Research Institute (CMRI); School of Medical Sciences: Pharmacology; School of Medical Sciences: Pharmacology; Medical Imaging and Radiation Sciences; School of Medical Sciences: Pathology; School of Medical Sciences: Pharmacology; School of Medical Sciences: Pharmacology; Children's Hospital Westmead: Childrens Medical Research InsPharmacology of novel small-molecule tubulin inhibitors in glioblastoma cells with enhanced EGFR signalling, Biochemical Pharmacology, vol.98, 4, 2015,pp 587-601
2017Structural optimization and pharmacological evaluation of inhibitors targeting dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) and CDC-like kinases (CLK) inglioblastomaAbbassi, Ramzi; Font Sadurni, Josep; Hoque, Monira; Kassiou, Michael; Munoz, Lenka; Phoa, Athena; Reekie, Tristan Andrew; Ryan, Renae; Zhou, Qingdi; Day, Bryan W.; Johns, Terrance G; Stringer, Brett W.; School of Medical Sciences: Pharmacology; School of Molecular Bioscience (SMB); Pharmacy; Chemistry; School of Medical Sciences: Pathology; School of Medical Sciences: Pharmacology; Medical Imaging and Radiation Sciences; School of Medical Sciences: Pharmacology; ChemistryStructural optimization and pharmacological evaluation of inhibitors targeting dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) and CDC-like kinases (CLK) inglioblastoma, Journal of Medicinal Chemistry, vol.60, 5, 2017,pp 2052-2070
2010Targeting p38 MAPK pathway for the treatment of Alzheimer's diseaseAmmit, Alaina; Munoz, Lenka; Pharmacy; School of Medical Sciences: PharmacologyTargeting p38 MAPK pathway for the treatment of Alzheimer's disease, Neuropharmacology, vol.58, 3, 2010,pp 561-568
2016Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-MimeticsMunoz, Lenka; Brumatti, Gabriela; Chau, Diep; et al, Various; Hanggi, Kay; Heckmann, Denise; Lalaoui, Najoua; Ma, Chunyan; Nguyen, Nhu-Y.N.; Spilgies, Lisanne; Vasilikos, Lazaros; School of Medical Sciences: PathologyTargeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics, Cancer Cell, vol.29, 2, 2016,pp 145-158