Browsing by Author Mikulec, Kathy

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Issue DateTitleAuthor(s)Citation
2014Activated Protein C (APC) can Increase Bone Anabolism via a Protease Activated Receptor (PAR)1/2 Dependent MechanismChan, Benjamin; Cheng, Tegan Laura; Jackson, Christopher; Little, David; Murphy, Ciara; Schindeler, Aaron; Xue, Meilang; Cheng, Tegan; Kolind, Mille; Mikulec, Kathy; Park, Sang-Youel; Peacock, Lauren; Shen, Kaitlin; Northern Clinical School: Surgery; Childrens Hospital Westmead: Paediatrics & Child Health; Northern Clinical School: Medicine; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child Health; Northern Clinical School: MedicineActivated Protein C (APC) can Increase Bone Anabolism via a Protease Activated Receptor (PAR)1/2 Dependent Mechanism, Journal of Orthopaedic Research, vol.32, 12, 2014,pp 1549-1556
2008Bisphosphonate-Laden Acrylic Bone Cement: Mechanical Properties, Elution Performance, and In Vivo ActivityLittle, David; Ruys, Andrew; Schindeler, Aaron; Yu, Nicole; Godfrey, Craig; Kiely, Patrick; McDonald, Michelle M; Mikulec, Kathy; Zenios, Michalis; Children's Hospital Westmead: Paediatrics & Child Health; Aerospace Mech & M'tronic Eng; Children's Hospital Westmead: Paediatrics & Child Health; Aerospace Mech & M'tronic EngBisphosphonate-Laden Acrylic Bone Cement: Mechanical Properties, Elution Performance, and In Vivo Activity, Journal of Biomedical Materials Research. Part B: Applied Biomaterials, vol.87B,(2),2008,pp 482-491
2011Characterization of the Bone Phenotype and Fracture Repair in Osteopetrotic Incisors Absent RatsLittle, David; Schindeler, Aaron; McDonald, Michelle M; Mikulec, Kathy; Morse, Alyson; Peacock, Lauren; Children's Hospital Westmead: Paediatrics & Child Health; Children's Hospital Westmead: Paediatrics & Child HealthCharacterization of the Bone Phenotype and Fracture Repair in Osteopetrotic Incisors Absent Rats, Journal of Orthopaedic Research: a journal for musculoskeletal investigation, vol.29, 5, 2011,pp 726-733
2014A collagen-hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonatesCantrill, Laurence; Little, David; Murphy, Ciara; Schindeler, Aaron; Yu, Nicole; Gleeson, John; Mikulec, Kathy; O'Brien, Fergal; Peacock, Lauren; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child HealthA collagen-hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates, Acta Biomaterialia, vol.10, N/A, 2014,pp 2250-2258
2014A combination of rhBMP-2 (recombinant human Bone Morphogenetic Protein-2) and MEK (MAP kinase/ERK kinase) inhibitor PD0325901 increases bone formation in a murine model of neurofibromatosis type I pseudarthrosisLittle, David; Schindeler, Aaron; Carpenter, Eleanor; Cheng, Tegan; Deo, N; El-Hoss, Jad; Mikulec, Kathy; Sullivan, K; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child HealthA combination of rhBMP-2 (recombinant human Bone Morphogenetic Protein-2) and MEK (MAP kinase/ERK kinase) inhibitor PD0325901 increases bone formation in a murine model of neurofibromatosis type I pseudarthrosis, Journal of Bone and Joint Surgery: American Volume, vol.96, 14, 2014,pp 1-11
2017Combination sclerostin antibody and zoledronic acid treatment outperforms either treatment alone in a mouse model of osteogenesis imperfectaCheng, Tegan Laura; Little, David; Munns, Craig; Schindeler, Aaron; Kneissel, M; Kramer, I; Mikulec, Kathy; Peacock, Lauren; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child HealthCombination sclerostin antibody and zoledronic acid treatment outperforms either treatment alone in a mouse model of osteogenesis imperfecta, Bone, vol.101, N/A, 2017,pp 96-103
2015Endochondral fracture healing with external fixation in the Sost knockout mouse results in earlier fibrocartilage callus removal and increased bone volume fraction and strengthLittle, David; Morse, Alyson; Yu, Nicole; Kneissel, M; Kramer, I; McDonald, Michelle M; Mikulec, Kathy; Peacock, Lauren; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child HealthEndochondral fracture healing with external fixation in the Sost knockout mouse results in earlier fibrocartilage callus removal and increased bone volume fraction and strength, Bone, vol.71, N/A, 2015,pp 155-163
2010In vivo local co-delivery of recombinant human bone morphogenetic protein-7 and pamidronate via poly-D, L-lactic acidLittle, David; Ruys, Andrew; Schindeler, Aaron; Yu, Nicole; Baldock, Paul A.; Mikulec, Kathy; Peacock, Lauren; Children's Hospital Westmead: Paediatrics & Child Health; Aerospace Mech & M'tronic Eng; Children's Hospital Westmead: Paediatrics & Child Health; Aerospace Mech & M'tronic EngIn vivo local co-delivery of recombinant human bone morphogenetic protein-7 and pamidronate via poly-D, L-lactic acid, European Cells and Materials, vol.20, N/A,pp 431-442
2015Inducible cell labeling and lineage tracking during fracture repairCantrill, Laurence; Little, David; Schindeler, Aaron; Summers, Matthew; Kolind, Mille; Mikulec, Kathy; Seime, Till; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child HealthInducible cell labeling and lineage tracking during fracture repair, Development, Growth and Differentiation, vol.57, 1, 2015,pp 10-23
2012Inhibition of Sclerostin by Systemic Treatment with Sclerostin Antibody Enhances Healing of Proximal Tibial Defects in Ovariectomized RatsLittle, David; Baldock, Paul A.; Birke, Oliver; Ke, Hua Zhu; Liu, Min; McDonald, Michelle M; Mikulec, Kathy; Morse, Alyson; Peacock, Lauren; Yu, N.Y.C.; Children's Hospital Westmead: Paediatrics & Child HealthInhibition of Sclerostin by Systemic Treatment with Sclerostin Antibody Enhances Healing of Proximal Tibial Defects in Ovariectomized Rats, Journal of Orthopaedic Research: a journal for musculoskeletal investigation, vol.30, 10, 2012,pp 1541-1548
2010Intermittent PTH (1-34) Does Not Increase Union Rates in Open Rat Femoral Fractures and Exhibits Attenuated Anabolic Effects Compared to Closed FracturesLittle, David; Amanat, Negin; Godfrey, Craig; McDonald, Michelle M; Mikulec, Kathy; Morse, Alyson; Peacock, Lauren; Tagil, Magnus; Children's Hospital Westmead: Paediatrics & Child HealthIntermittent PTH (1-34) Does Not Increase Union Rates in Open Rat Femoral Fractures and Exhibits Attenuated Anabolic Effects Compared to Closed Fractures, Bone, vol.46, 3,pp 852-859
2017Limitations of the Pax7-creER(T2) transgene for driving deletion of Nf1 in adult mouse muscleLittle, David; Schindeler, Aaron; Summers, Matthew; Mikulec, Kathy; Peacock, Lauren; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child Health; Exercise & Sport ScienceLimitations of the Pax7-creER(T2) transgene for driving deletion of Nf1 in adult mouse muscle, International Journal of Developmental Biology, vol.61, 8-Sep, 2017,pp 531-536
2015Lineage tracking of mesenchymal and endothelial progenitors in BMP-induced bone formationBobyn, Justin; Little, David; Schindeler, Aaron; Aiken, Alastair; Kalajzici, Ivo; Kolind, Mille; Matthews, Brya G; Mikulec, Kathy; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child HealthLineage tracking of mesenchymal and endothelial progenitors in BMP-induced bone formation, Bone, vol.81, N/A, 2015,pp 53-59
2017Local co-delivery of rhBMP-2 and cathepsin K inhibitor L006235 in poly(D,L-lactide-co-glycolide) nanospheresCantrill, Laurence; Dehghani, Fariba; Fathi, Ali; Little, David; Murphy, Ciara; Schindeler, Aaron; Yu, Nicole; Mikulec, Kathy; Peacock, Lauren; Childrens Hospital Westmead: Paediatrics & Child Health; Chemical & Biomolecular Engineering; Chemical & Biomolecular Engineering; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child HealthLocal co-delivery of rhBMP-2 and cathepsin K inhibitor L006235 in poly(D,L-lactide-co-glycolide) nanospheres, Journal of Biomedical Materials Research. Part B: Applied Biomaterials, vol.105B, 1, 2017,pp 136-144
2014Local delivery of recombinant human bone morphogenetic proteins and bisphosphonate via sucrose acetate isobutyrate can prevent femoral head collapse in Legg-Calve-Perthes disease: a pilot study in pigsCheng, Tegan Laura; Little, David; Schindeler, Aaron; Cantrill, Laurence; Carpenter, Clare E; Mikulec, Kathy; Murphy, Ciara; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child HealthLocal delivery of recombinant human bone morphogenetic proteins and bisphosphonate via sucrose acetate isobutyrate can prevent femoral head collapse in Legg-Calve-Perthes disease: a pilot study in pigs, International Orthopaedics, vol.38, 7, 2014,pp 1527-1533
2015Local delivery of the cationic steroid antibiotic CSA-90 enables osseous union in a rat open fracture model of Staphylococcus aureus infectionCheng, Tegan Laura; Little, David; Matthews, Ross; Mikulec, Kathy; Peacock, Lauren; Schindeler, Aaron; Sullivan, Kate; Yu, Nicole; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child Health; Childrens Hospital Westmead: Paediatrics & Child HealthLocal delivery of the cationic steroid antibiotic CSA-90 enables osseous union in a rat open fracture model of Staphylococcus aureus infection, Journal of Bone and Joint Surgery: American Volume, vol.97, 4, 2015,pp 302-309
2013Matrix Metalloproteinase – Driven Endochondral Fracture Union Proceeds Independently of Osteoclast ActivityLittle, David; Baldock, Paul A.; Kostenuik, P.; McDonald, Michelle M; Mikulec, Kathy; Morse, Alyson; Peacock, Lauren; Children's Hospital Westmead: Paediatrics & Child HealthMatrix Metalloproteinase – Driven Endochondral Fracture Union Proceeds Independently of Osteoclast Activity, Journal of Bone and Mineral Research, vol.28, 7, 2013,pp 1550-1560
2008Modeling Bone Morphogenetic Protein and Bisphosphonate Combination Therapy in Wild-Type and Nf1 Haploinsufficient MiceLittle, David; Schindeler, Aaron; Godfrey, Craig B.; McDonald, Michelle M; Mikulec, Kathy; Morse, Alyson; Ramachandran, Manoj; Children's Hospital Westmead: Paediatrics & Child Health; Children's Hospital Westmead: Paediatrics & Child HealthModeling Bone Morphogenetic Protein and Bisphosphonate Combination Therapy in Wild-Type and Nf1 Haploinsufficient Mice, Journal of Orthopaedic Research, vol.26,(1),2008,pp 65-74
2008Models of Tibial Fracture Healing in Normal and Nf1-Deficient MiceLittle, David; Schindeler, Aaron; Gasser, Jurg A.; Godfrey, Craig; Harry, Lorraine; McDonald, Michelle; Mikulec, Kathy; Morse, Alyson; Children's Hospital Westmead: Paediatrics & Child Health; Children's Hospital Westmead: Paediatrics & Child HealthModels of Tibial Fracture Healing in Normal and Nf1-Deficient Mice, Journal of Orthopaedic Research, vol.26,(8),2008,pp 1053-1060
2013Modulation of anabolic and catabolic responses via a porous polymer scaffold manufactured using thermally induced phase separationLittle, David; Ruys, Andrew; Schindeler, Aaron; Yu, Nicole; Cooper-White, Justin; Fitzpatrick, Jane; Mikulec, Kathy; Peacock, Lauren; Children's Hospital Westmead: Paediatrics & Child Health; Aerospace Mech & M'tronic Eng; Children's Hospital Westmead: Paediatrics & Child Health; Children's Hospital Westmead: Paediatrics & Child HealthModulation of anabolic and catabolic responses via a porous polymer scaffold manufactured using thermally induced phase separation, European Cells and Materials, vol.25, N/A, 2013,pp 190-203