Browsing by Author Gavande, Navnath

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Issue DateTitleAuthor(s)Citation
20122'-Methoxy-6-methylflavone: A novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptorsCollins (Chebib), Mary; Gavande, Navnath; Hanrahan, Jane; Johnston, Graham; Karim, Nasiara; Curmi, John; Tierney, Louise; Pharmacy; Pharmacy; Pharmacy; School of Medical Sciences: Pharmacology; Pharmacy2'-Methoxy-6-methylflavone: A novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors, British Journal of Pharmacology, vol.165, 4, 2012,pp 880-896
20113-Hydroxy-2'-methoxy-6-methylflavone: A potent anxiolytic with a unique selectivity profile at GABBA receptor subtypesCollins (Chebib), Mary; Gavande, Navnath; Hanrahan, Jane; Johnston, Graham; Karim, Nasiara; Wellendorph, Petrine; Pharmacy; Pharmacy; Pharmacy; School of Medical Sciences: Pharmacology; Pharmacy3-Hydroxy-2'-methoxy-6-methylflavone: A potent anxiolytic with a unique selectivity profile at GABBA receptor subtypes, Biochemical Pharmacology, vol.82, 12, 2011,pp 1971-1983
20097-Hydroxy-benzopyran-4-one Derivatives: A Novel Pharmacophore of Peroxisome Proliferator-Activated Receptor and - (PPAR and ) Dual AgonistsGavande, Navnath; Hanrahan, Jane; Hibbs, David; Kim, Moon; Matin, Azadeh; Roubin, Rebecca; Salam, Noeris; Yang, Nancy; Pharmacy; Pharmacy; Pharmacy; Pharmacy; Pharmacy; Pharmacy; Pharmacy; Pharmacy7-Hydroxy-benzopyran-4-one Derivatives: A Novel Pharmacophore of Peroxisome Proliferator-Activated Receptor and - (PPAR and ) Dual Agonists, Journal of Medicinal Chemistry, vol.52, N/A,pp 6835-6850
2011Agonist responses of (R)- and (S)-3-fluoro-??-aminobutyric acids suggest an enantiomeric fold for GABA binding to GABA(C) receptorsCollins (Chebib), Mary; Gavande, Navnath; Johnston, Graham; Yamamoto, Izumi; Deniau, Gildas; O'Hagan, David; Pharmacy; Pharmacy; School of Medical Sciences: Pharmacology; PharmacyAgonist responses of (R)- and (S)-3-fluoro-??-aminobutyric acids suggest an enantiomeric fold for GABA binding to GABA(C) receptors, Chemical Communications, vol.47, 28, 2011,pp 7956-7958
2013Design, synthesis, and pharmacological evaluation of fluorescent and biotinylated antagonists of P1 GABA(c) receptorsCollins (Chebib), Mary; Doddareddy, Munikumar; Gavande, Navnath; Hanrahan, Jane; Johnston, Graham; Kim, Hye-Lim; Pharmacy; School of Medical Sciences: Brain & Mind Research Institute; Pharmacy; Pharmacy; School of Medical Sciences: Pharmacology; PharmacyDesign, synthesis, and pharmacological evaluation of fluorescent and biotinylated antagonists of P1 GABA(c) receptors, A C S Medicinal Chemistry Letters, vol.4, 4, 2013,pp 402-407
2012Differentiating Enantioselective Actions of GABOB: A Possible Role for Threonine 244 in the Binding Site of GABAC rho1 ReceptorsAbsalom, Nathan Luke; Carland, Jane; Collins, Mary; Doddareddy, Munikumar; Gavande, Navnath; Hanrahan, Jane; Johnston, Graham; Yamamoto, Izumi; Pharmacy; School of Medical Sciences: Pharmacology; Pharmacy; School of Medical Sciences: Brain and Mind Centre; Pharmacy; Pharmacy; School of Medical Sciences: Pharmacology; PharmacyDifferentiating Enantioselective Actions of GABOB: A Possible Role for Threonine 244 in the Binding Site of GABAC rho1 Receptors, ACS Chemical Neuroscience, vol.3, 9, 2012,pp 665-673
2013The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonistsDoddareddy, Munikumar; Gavande, Navnath; Groundwater, Paul; Hibbs, David; Matin, Azadeh; Roubin, Rebecca; Nammi, Srinivas; School of Medical Sciences: Brain & Mind Research Institute; Pharmacy; Pharmacy; Pharmacy; Pharmacy; PharmacyThe discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists, Bioorganic and Medicinal Chemistry: the tetrahedron journal for research at the interface of chemistry and biology, vol.21, 3, 2013,pp 766-778
2012The enantiomers of syn-2,3-difluoro-4-aminobutyric acid elicit opposite responses at the GABA(C) receptorCollins (Chebib), Mary; Doddareddy, Munikumar; Gavande, Navnath; Hunter, Luke; Jordan, Meredith; Yamamoto, Izumi; Pharmacy; Brand Management; Pharmacy; Chemistry; Chemistry; PharmacyThe enantiomers of syn-2,3-difluoro-4-aminobutyric acid elicit opposite responses at the GABA(C) receptor, Chemical Communications, vol.48, 6, 2012,pp 829-831
2009Guanidino Acids Act as p1 GABAc Receptor AntagonistsAllan, Robin; Collins, Mary; Duke, Rujee; Gavande, Navnath; Hanrahan, Jane; Johnston, Graham; Mewett, Kenneth; Park, Anna; Premoli, Isabella; Wong, Kit; School of Medical Sciences: Pharmacology; Pharmacy; School of Medical Sciences: Pharmacology; Pharmacy; Pharmacy; School of Medical Sciences: Pharmacology; School of Medical Sciences: Pharmacology; Pharmacy; Pharmacy; Western Clinical School: SurgeryGuanidino Acids Act as p1 GABAc Receptor Antagonists, Neurochemical Research, vol.34, 10, 2009,pp 1704-1711
2011Identification of Benzopyran-4-one Derivatives (Isoflavones) as Positive Modulators of GABAA ReceptorsCollins (Chebib), Mary; Gavande, Navnath; Hanrahan, Jane; Johnston, Graham; Karim, Nasiara; Pharmacy; Pharmacy; Pharmacy; School of Medical Sciences: Pharmacology; PharmacyIdentification of Benzopyran-4-one Derivatives (Isoflavones) as Positive Modulators of GABAA Receptors, ChemMedChem: chemistry enabling drug discovery, vol.6, 8, 2011,pp 1340-1346
2011Medicinal Chemistry of p GABAc ReceptorsCollins (Chebib), Mary; Gavande, Navnath; Hanrahan, Jane; Johnston, Graham; Kim, Hye-Lim; Kumar, Rohan; Mewett, Kenneth; Ng, Clarissa; Yamamoto, Izumi; Pharmacy; Pharmacy; Pharmacy; School of Medical Sciences: Pharmacology; Pharmacy; Pharmacy; School of Medical Sciences: Pharmacology; Pharmacy; PharmacyMedicinal Chemistry of p GABAc Receptors, Future Medicinal Chemistry, vol.3, 2, 2011,pp 197-209
2010Microwave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: Application to four-step synthesis of gabazine (SR-95531)Collins (Chebib), Mary; Gavande, Navnath; Hanrahan, Jane; Johnston, Graham; Pharmacy; Pharmacy; Pharmacy; School of Medical Sciences: PharmacologyMicrowave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: Application to four-step synthesis of gabazine (SR-95531), Organic & Biomolecular Chemistry, vol.8, N/A,pp 4131-4136
2011Novel Cyclic Phosphinic Acids as GABAC F Receptor Antagonists: Design, Synthesis, and PharmacologyBurden, Peter; Collins (Chebib), Mary; Gavande, Navnath; Hanrahan, Jane; Johnston, Graham; Tu-Hoa, Ai; Yamamoto, Izumi; Salam, Noeris; School of Medical Sciences: Pharmacology; Pharmacy; Pharmacy; Pharmacy; School of Medical Sciences: Pharmacology; School of Medical Sciences: Pharmacology; PharmacyNovel Cyclic Phosphinic Acids as GABAC F Receptor Antagonists: Design, Synthesis, and Pharmacology, A C S Medicinal Chemistry Letters, vol.2, N/A, 2011,pp 11-16
2009Regulation of Low-Density Lipoprotein Receptor and 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Expression by Zingiber officinale in the Liver of High-Fat Diet-Fed RatsGavande, Navnath; Kim, Moon; Li, George Qian; Nammi, Srinivas; Roufogalis, Basil; Pharmacy; Pharmacy; Pharmacy; Pharmacy; PharmacyRegulation of Low-Density Lipoprotein Receptor and 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Expression by Zingiber officinale in the Liver of High-Fat Diet-Fed Rats, Basic and Clinical Pharmacology and Toxicology, vol.106, 5, 2009,pp 389-395
2012Structurally Diverse GABA Antagonists Interact Differently with Open and Closed Conformational States of the p1 ReceptorAbsalom, Nathan; Allan, Robin; Carland, Jane; Collins (Chebib), Mary; Gavande, Navnath; Hanrahan, Jane; Johnston, Graham; Locock, Katherine; Yamamoto, Izumi; Pharmacy; School of Medical Sciences: Pharmacology; Pharmacy; Pharmacy; Pharmacy; Pharmacy; School of Medical Sciences: Pharmacology; School of Medical Sciences: Pharmacology; PharmacyStructurally Diverse GABA Antagonists Interact Differently with Open and Closed Conformational States of the p1 Receptor, ACS Chemical Neuroscience, vol.3, 4, 2012,pp 293-301