Browsing by Author Gajhede, Michael

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Showing results 1 to 7 of 7
Issue DateTitleAuthor(s)Citation
2015Acetylcholine-Binding Protein Engineered to Mimic the alpha4-alpha4 Binding Pocket in alpha4beta2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and ActivityAhring, Joergen Phillip; Balle, Thomas; Olsen, Jeppe; Gajhede, Michael; Kastrup, Jette Sandholm; Krintel, Christian; Shahsavar, Azadeh; Pharmacy; Pharmacy; PharmacyAcetylcholine-Binding Protein Engineered to Mimic the alpha4-alpha4 Binding Pocket in alpha4beta2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity, Molecular Pharmacology, vol.88, 4, 2015,pp 697-707
2015Engineered alpha4beta2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity alpha4-alpha4 interfaceAhring, Joergen Phillip; Balle, Thomas; Collins, Mary; Indurthi Venkata, Dinesh; Olsen, Jeppe; Gajhede, Michael; Kastrup, Jette Sandholm; Nielsen, Elsebet Ostergaard; Pedersen, Martin H.F.; Peters, Dan; Rohde, Line A.; Shahsavar, Azadeh; Pharmacy; Pharmacy; Pharmacy; Pharmacy; PharmacyEngineered alpha4beta2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity alpha4-alpha4 interface, Neuropharmacology, vol.92, N/A, 2015,pp 135-145
2013Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptorsBalle, Thomas; Ahring, Philip; Dyhring, Tino; Gajhede, Michael; Hald, Helle; Harpsoe, Kasper; Jensen, Marianne; Kastrup, Jette Sandholm; Nielsen, Elsebet; Peters, Dan; Timmermann, Daniel; PharmacyMolecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors, JBC Papers in Press, vol.288, 4, 2013,pp 2559-2570
2014Molecular Recognition of the Neurotransmitter Acetylcholine by an Acetylcholine Binding Protein Reveals Determinants of Binding to Nicotinic Acetylcholine ReceptorsAhring, Joergen Phillip; Balle, Thomas; Gajhede, Michael; Kastrup, Jette Sandholm; Olsen, Jeppe; Pharmacy; PharmacyMolecular Recognition of the Neurotransmitter Acetylcholine by an Acetylcholine Binding Protein Reveals Determinants of Binding to Nicotinic Acetylcholine Receptors, PloS One, vol.9, 3, 2014,pp 1-8
2014Structural and Functional Studies of the Modulator NS9283 Reveal Agonist-like Mechanism of Action at a4B2 Nicotinic Acetylcholine ReceptorsAhring, Joergen Phillip; Balle, Thomas; Olsen, Jeppe; Gajhede, Michael; Kastrup, Jette Sandholm; Pharmacy; Pharmacy; PharmacyStructural and Functional Studies of the Modulator NS9283 Reveal Agonist-like Mechanism of Action at a4B2 Nicotinic Acetylcholine Receptors, The Journal of Biological Chemistry, vol.289, 36, 2014,pp 24911-24921
2013Synthesis, pharmacology, and biostructural characterization of novel alpha4beta2 nicotinic acetylcholine receptor agonistsBalle, Thomas; Ahring, Philip; Frølund, Bente; Gajhede, Michael; Hansen, Camilla P; Jensen, Anders; Kastrup, Jette Sandholm; Nielsen, Elsebet; Petersen, Jette; Rohde, Line Aagot Hede; Ussing, Christine; PharmacySynthesis, pharmacology, and biostructural characterization of novel alpha4beta2 nicotinic acetylcholine receptor agonists, Journal of Medicinal Chemistry, vol.56, 3, 2013,pp 940-951
2013Two Distinct Allosteric Binding Sites at a4B2 Nicotinic Acetylcholine Receptors Revealed by NS206 and NS9283 Give Unique Insights to Binding Activity-associated Linkage at Cys-loop ReceptorsAhring, Joergen; Balle, Thomas; Gajhede, Michael; Kastrup, Jette Sandholm; Olsen, Jeppe; Peters, Dan; Pharmacy; PharmacyTwo Distinct Allosteric Binding Sites at a4B2 Nicotinic Acetylcholine Receptors Revealed by NS206 and NS9283 Give Unique Insights to Binding Activity-associated Linkage at Cys-loop Receptors, The Journal of Biological Chemistry, vol.288, 50, 2013,pp 35997-36006