Browsing by Author Frolund, Bente

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Issue DateTitleAuthor(s)Citation
20145-(Piperidin-4-yl)-3-Hydroxypyrazole: A Novel Scaffold for Probing the Orthosteric gamma-Aminobutyric Acid Type A Receptor Binding SiteBalle, Thomas; Sorensen, Troels; Frolund, Bente; Jensen, Anders; Kongstad, Kenneth T; Krall, Jacob; Nielsen, Birgitte; Pharmacy; Pharmacy5-(Piperidin-4-yl)-3-Hydroxypyrazole: A Novel Scaffold for Probing the Orthosteric gamma-Aminobutyric Acid Type A Receptor Binding Site, ChemMedChem: chemistry enabling drug discovery, vol.9, 11, 2014,pp 2475-2485
2012(alpha)4(beta)(delta) GABAA receptors are high-affinity targets for gamma-hydroxybutyric acid (GHB)Absalom, Nathan; Collins (Chebib), Mary; Karim, Nasiara; Bay, Tina; Brauner-Osborne, Hans; Clausen, Rasmus; Eghorn, Laura; Frolund, Bente; Knudsen, Gitte; Olsen, Jesper; Villumsen, Inge; Wellendorph, Petrine; Pharmacy; Pharmacy; Pharmacy(alpha)4(beta)(delta) GABAA receptors are high-affinity targets for gamma-hydroxybutyric acid (GHB), Proceedings of the National Academy of Sciences (PNAS), vol.109, 33, 2012,pp 13404-13409
2015Exploration of the molecular architecture of the orthosteric binding site in the alpha4beta2 nicotinic acetylcholine receptor with analogs of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) and 1-(pyridin-3-yl)-1,4-diazepaneBalle, Thomas; Liu, Jun; Sorensen, Troels; Bach, Tinna; Blaazer, Antoni; Della Volpe, Serena; Frolund, Bente; Jensen, Anders; Petersen, Jette; Van Muijlwijk-Koezen, Jacqueline; Pharmacy; Pharmacy; PharmacyExploration of the molecular architecture of the orthosteric binding site in the alpha4beta2 nicotinic acetylcholine receptor with analogs of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) and 1-(pyridin-3-yl)-1,4-diazepane, European Journal of Medicinal Chemistry, vol.102, N/A, 2015,pp 425-444
2013Exploring the Orthosteric Binding Site of the y-Aminobutyric Acid Type A Receptor Using 4-(Piperidin-4-yl)-1-hydroxypyrazoles 3- or 5-Imidazolyl Substituted: Design, Synthesis, and Pharmacological EvaluationBalle, Thomas; Sorensen, Troels; Frolund, Bente; Jensen, Anders; Jensen, Claus H; Krall, Jacob; Nielsen, Birgitte; Sander, Tommy; Pharmacy; PharmacyExploring the Orthosteric Binding Site of the y-Aminobutyric Acid Type A Receptor Using 4-(Piperidin-4-yl)-1-hydroxypyrazoles 3- or 5-Imidazolyl Substituted: Design, Synthesis, and Pharmacological Evaluation, Journal of Medicinal Chemistry, vol.56, 16, 2013,pp 6536-6540
2015GABAA receptor partial agonists and antagonists: Structure, binding mode, and pharmacologyBalle, Thomas; Sorensen, Troels; Frolund, Bente; Krall, Jacob; Kristiansen, Uffe; Krogsgaard-Larsen, Niels; Krogsgaard-Larsen, Povl; Pharmacy; PharmacyGABAA receptor partial agonists and antagonists: Structure, binding mode, and pharmacology, Advances in Pharmacology, vol.72, N/A, 2015,pp 201-227
2011New insights into the GABAA receptor structure and orthosteric ligand binding: Receptor modeling guided by experimental dataBalle, Thomas; Bruun, Anne Techau; Frolund, Bente; Ivanov, Ivaylo; McCammon, James Andrew; Sander, Tommy; PharmacyNew insights into the GABAA receptor structure and orthosteric ligand binding: Receptor modeling guided by experimental data, Proteins: Structure, Function, and Bioinformatics, vol.79, N/A, 2011,pp 1458-1477
2014Probing the Orthosteric Binding Site of GABAA Receptors with Heterocyclic GABA Carboxylic Acid Bioisosteres.Balle, Thomas; Bergmann, Rikke; Frolund, Bente; Krogsgarrd-Larsen, Povl; Petersen, Jette; PharmacyProbing the Orthosteric Binding Site of GABAA Receptors with Heterocyclic GABA Carboxylic Acid Bioisosteres., Neurochemical Research, vol.39, 6, 2014,pp 1005-1015