Browsing by Author Fazakerley, Daniel

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Issue DateTitleAuthor(s)Citation
2014Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivoJames, David; Fazakerley, Daniel; Jensen, Thomas E.; Jordy, Andreas B; Kiens, Bente; Kleinert, Maximillian; Krycer, James; Oxbøll, Anne-Julie; Richter, Erik A; Ruegg, Markus A; Schjerling, Peter; Sylow Hansen, Lykke; Thomas, Kristen; Yang, Guang; Molecular BioscienceAcute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo, Molecular Metabolism, vol.3, 6, 2014,pp 630-641
2017Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migrationBalaban, Seher; Cairns, Rose; Fazakerley, Daniel; Grewal, Thomas; Holst, Jeffrey; Hoy, Andrew; Lee, Lisa; Schreuder, Mark; Shtein, Harrison; Thomas, Kristen; van Geldermalsen, Michelle; Saunders, Darren N.; Shearer, Robert F.; School of Medical Sciences: Physiology; School of Medical Sciences: Pharmacology; School of Molecular Bioscience (SMB); Pharmacy; Central Clinical School: Centenary Institute; School of Medical Sciences: Physiology; School of Medical Sciences: Physiology; School of Medical Sciences: Physiology; School of Medical Sciences: Brain and Mind Centre; School of Life and Environmental Sciences (SOLES); Central Clinical School: Centenary InstituteAdipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration, Cancer and Metabolism, vol.5, 1, 2017,pp N/A-N/A
2017The amino acid transporter SLC1A3 is plasma membrane-localised in adipocytes and its activity is insensitive to insulinBurchfield, James; Cater, Rosemary; Fazakerley, Daniel; Humphrey, Sean; James, David; Krycer, James; Naghiloo, Sheyda; Ryan, Renae; Thomas, Kristen; Vandenberg, Robert; School of Life and Environmental Sciences (SOLES); School of Medical Sciences: Pharmacology; School of Life and Environmental Sciences (SOLES); School of Life and Environmental Sciences (SOLES); School of Life and Environmental Sciences (SOLES); School of Life and Environmental Sciences (SOLES); School of Molecular Bioscience (SMB); School of Medical Sciences: Pharmacology; School of Life and Environmental Sciences (SOLES); School of Medical Sciences: PharmacologyThe amino acid transporter SLC1A3 is plasma membrane-localised in adipocytes and its activity is insensitive to insulin, FEBS Letters, vol.591, 2, 2017,pp 322-330
2017Bicarbonate alters cellular responses in respiration assaysFazakerley, Daniel; James, David; Krycer, James; Fisher-Wellman, Kelsey; Muoio, Deborah M; School of Molecular Bioscience (SMB); School of Life and Environmental Sciences (SOLES); School of Molecular Bioscience (SMB)Bicarbonate alters cellular responses in respiration assays, Biochemical and Biophysical Research Communications, vol.489, N/A, 2017,pp 399-403
2015Cross-species gene expression analysis identifies a novel set of genes implicated in human insulin sensitivityChaudhuri, Rima; Fazakerley, Daniel; Hocking, Samantha; James, David; Stockli, Jacqueline; Yang, Jean Yee Hwa; Greenfield, Jerry R; Hoehn, Kyle L; Junutula, Jagath R.; Khoo, Poh Sim; Kolumam, Ganesh; Meoli, Christopher C.; Modrusan, Zora; Samocha-Bonet, Dorit; Tonks, Katherine; Molecular Bioscience; Molecular Bioscience; Northern Clinical School: Medicine; Molecular Bioscience; Molecular Bioscience; Mathematics & StatisticsCross-species gene expression analysis identifies a novel set of genes implicated in human insulin sensitivity, Npj Systems Biology And Applications, vol.1, N/A, 2015,pp 1-10
2014Direction pathway analysis of large-scale proteomics data reveals novel features of the insulin action pathwayPatrick, Ellis; Yang, Jean Yee Hwa; Yang, Pengyi; Burchfield, James; Fazakerley, Daniel; Gribben, Christopher; James, David; Prior, Matthew; Tan, Shi-Xiong; Mathematics & Statistics; Mathematics & Statistics; Schl Information TechnologiesDirection pathway analysis of large-scale proteomics data reveals novel features of the insulin action pathway, Bioinformatics, vol.30, 6, 2014,pp 808-814
2013Dynamic adipocyte phosphoproteome reveals that akt directly regulates mTORC2Yang, Pengyi; Yang, Yee (Jean); Fazakerley, Daniel; Humphrey, Sean; James, David; Stockli, Jacqueline; Yang, Guang; Schl Information Technologies; Mathematics & StatisticsDynamic adipocyte phosphoproteome reveals that akt directly regulates mTORC2, Cell Metabolism, vol.17, 6, 2013,pp 1009-1020
2017Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose MetabolismCooney, Gregory; Domanova, Westa; Fazakerley, Daniel; Healy, Marin; Humphrey, Sean; James, David; Krycer, James; Parker, Benjamin Leo; Quek, Lake-Ee; Scalzo, Richard; et al, Various; Hirayama, Akiyoshi; Hodson, Mark P.; Hoehn, Kyle L; Ikeda, Satsuki; Ohno, Satoshi; Shoji, Futaba; Suzuki, Kumi; Turner, Nigel; Yugi, Katsuyuki; School of Medical Sciences: School of Medical Sciences; Physics; School of Life and Environmental Sciences (SOLES); School of Molecular Bioscience (SMB); School of Life and Environmental Sciences (SOLES); School of Life and Environmental Sciences (SOLES); School of Life and Environmental Sciences (SOLES); School of Life and Environmental Sciences (SOLES); Mathematics & Statistics; Engineering & IT AdministrationDynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism, Cell Reports, vol.21, 12, 2017,pp 3536-3547
2015Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK SubstratesBurchfield, James; Chaudhuri, Rima; Fazakerley, Daniel; Hoffman, Nolan; Holliday, Mira; James, David; Parker, Benjamin Leo; Stoeckli, Jacqueline; Fisher-Wellman, Kelsey H; Humphrey, Sean; Jensen, Thomas E.; Jothi, Raja; Kiens, Bente; Kleinert, Maximillian; Richter, Erik A; Trefely, Sophie; Wojtaszewski, Jorgen F P; Yang, Pengyi; Molecular Bioscience; Molecular Bioscience; Molecular Bioscience; Molecular Bioscience; Biological Sciences; Molecular Bioscience; Molecular Bioscience; Molecular BioscienceGlobal Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates, Cell Metabolism, vol.22, 5, 2015,pp 922-935
2017An improved Akt reporter reveals intra- and inter-cellular heterogeneity and oscillations in signal transductionBurchfield, James; Fazakerley, Daniel; James, David; Krycer, James; Norris, Dougall; Yang, Pengyi; School of Life and Environmental Sciences (SOLES); School of Life and Environmental Sciences (SOLES); School of Life and Environmental Sciences (SOLES); School of Life and Environmental Sciences (SOLES); School of Life and Environmental Sciences (SOLES); Mathematics & StatisticsAn improved Akt reporter reveals intra- and inter-cellular heterogeneity and oscillations in signal transduction, Journal of Cell Science, vol.130, N/A, 2017,pp 2757-2766
2015Insulin regulates Rab3–Noc2 complex dissociation to promote GLUT4 translocation in rat adipocytesFazakerley, Daniel; Holman, Geoffrey David; Koumanov, Francoise; Pereira, Vinit J; Richardson, Judith D; Sargent, Samantha L; Molecular BioscienceInsulin regulates Rab3–Noc2 complex dissociation to promote GLUT4 translocation in rat adipocytes, Diabetologia, vol.58, 8, 2015,pp 1877-1886
2015Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/IGF-1 Signalling PathwayChaudhuri, Rima; Fazakerley, Daniel; James, David; Krycer, James; Parker, Benjamin Leo; Stoeckli, Jacqueline; Jung, Kenneth; Junutula, Jagath R.; Khoo, Poh-Sim; Kuijl, Coenraad; Lee, James; Stephan, Jean-Philippe; Sultani, Ghazal; Torres, Eric; Trefely, Sophie; Molecular Bioscience; Molecular Bioscience; School of Life and Environmental Sciences (SOLES); Molecular Bioscience; Molecular Bioscience; Molecular BioscienceKinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/IGF-1 Signalling Pathway, The Journal of Biological Chemistry, vol.290, 43, 2015,pp 25834-25846
2011Mapping Insulin/GLUT4 CircuitryJames, David; Fazakerley, Daniel; Rowland, Alexander; Medicine Faculty OfficeMapping Insulin/GLUT4 Circuitry, Traffic: the international journal of intracellular transport, vol.12, 6, 2011,pp 672-681
2018Membrane Topology of Trafficking Regulator of GLUT4 1 (TRARG1)Cooke, Kristen; Duan, Xiaowen; Fazakerley, Daniel; James, David; Krycer, James; Yang, Guang; School of Life and Environmental Sciences (SOLES); Charles Perkins Centre; School of Life and Environmental Sciences (SOLES); School of Life and Environmental Sciences (SOLES); School of Life and Environmental Sciences (SOLES); School of Life and Environmental Sciences (SOLES)Membrane Topology of Trafficking Regulator of GLUT4 1 (TRARG1), Biochemistry, vol.57, 26, 2018,pp 3606-3615
2018Membrane Topology of Trafficking Regulator of GLUT4 1 (TRARG1)Cooke, Kristen; Duan, Xiaowen; Fazakerley, Daniel; James, David; Krycer, James; Yang, Guang; School of Life and Environmental Sciences (SOLES); Charles Perkins Centre; School of Life and Environmental Sciences (SOLES); School of Life and Environmental Sciences (SOLES); School of Life and Environmental Sciences (SOLES); School of Life and Environmental Sciences (SOLES)Membrane Topology of Trafficking Regulator of GLUT4 1 (TRARG1), Biochemistry, vol.57, 26, 2018,pp 3606-3615
2017Metabolomic analysis of insulin resistance across different mouse strains and dietsChaudhuri, Rima; Cooney, Gregory; Fazakerley, Daniel; Hoffman, Nolan; James, David; Stöckli, Jacqueline; Thomas, Kristen; Zeng, Xiaoyi; Andrikopoulos, Sofianos; Fisher-Wellman, Kelsey H; Ilkayeva, Olga; Mangiafico, S; Meoli, Christopher C.; Muoio, Deborah M; Wong, Kari; Xirouchaki, Chrysovalantou E; Yang, Chieh-Hsin; School of Life and Environmental Sciences (SOLES); School of Medical Sciences: School of Medical Sciences; School of Life and Environmental Sciences (SOLES); School of Life and Environmental Sciences (SOLES); School of Life and Environmental Sciences (SOLES); School of Life and Environmental Sciences (SOLES); School of Life and Environmental Sciences (SOLES); School of Life and Environmental Sciences (SOLES)Metabolomic analysis of insulin resistance across different mouse strains and diets, Journal of Biological Chemistry, vol.292, 47, 2017,pp 19135-19145
2016mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in AdipocytesDomanova, Westa; Fazakerley, Daniel; Humphrey, Sean; James, David; Minard, Annabel; Parker, Benjamin Leo; Stoeckli, Jacqueline; Yang, Pengyi; Jothi, Raja; Tan, Shi-Xiong; Physics; School of Molecular Bioscience (SMB); School of Life and Environmental Sciences (SOLES); School of Life and Environmental Sciences (SOLES); School of Life and Environmental Sciences (SOLES); School of Molecular Bioscience (SMB); School of Life and Environmental Sciences (SOLES); Mathematics & StatisticsmTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes, Cell Reports, vol.17, 1, 2016,pp 29-36
2016mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in AdipocytesDomanova, Westa; Fazakerley, Daniel; Humphrey, Sean; James, David; Minard, Annabel; Parker, Benjamin Leo; Stoeckli, Jacqueline; Yang, Pengyi; Jothi, Raja; Tan, Shi-Xiong; Physics; Molecular Bioscience; School of Life and Environmental Sciences (SOLES); School of Life and Environmental Sciences (SOLES); School of Life and Environmental Sciences (SOLES); Molecular Bioscience; School of Life and Environmental Sciences (SOLES); Mathematics & StatisticsmTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes, Cell Reports, vol.17, 1, 2016,pp 29-36
2016mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3Chaudhuri, Rima; Fazakerley, Daniel; Hoffman, Nolan; James, David; Krycer, James; Parker, Benjamin Leo; Thomas, Kristen; Fritzen, Andreas; Jeppesen, Jacob; Kiens, Bente; Kleinert, Maximillian; Richter, Erik A; Ruegg, Markus A; Schjerling, Peter; Serup, Annette; Sylow Hansen, Lykke; Molecular Bioscience; Molecular Bioscience; Molecular Bioscience; School of Life and Environmental Sciences (SOLES); Molecular Bioscience; Molecular Bioscience; School of Life and Environmental Sciences (SOLES)mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3, Molecular Metabolism, vol.5, 8, 2016,pp 646-655
2016mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3Chaudhuri, Rima; Fazakerley, Daniel; Hoffman, Nolan; James, David; Krycer, James; Parker, Benjamin Leo; Thomas, Kristen; Fritzen, Andreas; Jeppesen, Jacob; Kiens, Bente; Kleinert, Maximillian; Richter, Erik A; Ruegg, Markus A; Schjerling, Peter; Serup, Annette; Sylow Hansen, Lykke; Molecular Bioscience; Molecular Bioscience; Molecular Bioscience; School of Life and Environmental Sciences (SOLES); Molecular Bioscience; Molecular Bioscience; School of Life and Environmental Sciences (SOLES)mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3, Molecular Metabolism, vol.5, 8, 2016,pp 646-655