Browsing by Author Downes, Michael

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Issue DateTitleAuthor(s)Citation
20152-Methyl-4-chlorophenoxyacetic acid and bromoxynil herbicide deathBuckley, Nicholas Allan; Berling, Ingrid; Downes, Michael; Grice, Jeffrey E; Isbister, Geoffrey K.; Medley, Gregory; Mostafa, Ahmed; Roberts, Michael S; School of Medical Sciences: Pharmacology2-Methyl-4-chlorophenoxyacetic acid and bromoxynil herbicide death, Clinical Toxicology, vol.53, 5, 2015,pp 486-488
2014Barx2 and Pax7 Have Antagonistic Functions in Regulation of Wnt Signaling and Satellite Cell DifferentiationLiddle, Christopher; Downes, Michael; Evans, Ronald; Gromova, Anastasia; Hulin, Julie-Ann; Makarenkova, Helen; Meech, Robyn; Nguyen, Thi Diem Tran; Yu, Ruth; Zhuang, Lizhe; Western Clinical School: Medicine (Westmead)Barx2 and Pax7 Have Antagonistic Functions in Regulation of Wnt Signaling and Satellite Cell Differentiation, Stem Cells, vol.32, 6, 2014,pp 1661-1673
2006Benefit of farnesoid X receptor inhibition in obstructive cholestasis.Coulter, Sally; Liddle, Christopher; Stedman, Catherine; Alvarez, Jacqueline G. A.; Downes, Michael; Evans, Ronald M.; Sonoda, Junichiro; School of Medical Sciences: Pharmacology; Western Clinical School: Medicine (Westmead); Clinical SchoolsBenefit of farnesoid X receptor inhibition in obstructive cholestasis., Proceedings of the National Academy of Sciences, vol.103,(30),2006,pp 11323-11328
2015BRD4 is a novel therapeutic target for liver fibrosisLiddle, Christopher; Benner, Chris; Ding, Ning; Downes, Michael; Evans, Ronald Mark; Hah, Nasun; He, Mingxiao; Leblanc, Mathias; Sherman, Mara; Yu, Ruth T; Western Clinical School: Medicine (Westmead)BRD4 is a novel therapeutic target for liver fibrosis, Proceedings of the National Academy of Sciences of the United States of America (PNAS), vol.112, 51, 2015,pp 15713-15718
2015Calcipotriol Targets LRP6 to Inhibit Wnt Signaling in Pancreatic CancerLiddle, Christopher; Arensman, Michael D; Dawson, David W; Downes, Michael; Evans, Ronald; Kershaw, Kathleen M; Lay, Anna R; Nguyen, Phillip; Ostertag-Hill, Claire A; Sherman, Mara; Western Clinical School: Medicine (Westmead)Calcipotriol Targets LRP6 to Inhibit Wnt Signaling in Pancreatic Cancer, Molecular Cancer Research, vol.N/A, N/A, 2015,pp N/A-N/A
2016Cistromic and genetic evidence that the vitamin D receptor mediates susceptibility to latitude-dependent autoimmune diseasesBooth, David; Coulter, Sally; Liddle, Christopher; Parnell, Grant; Schibeci, Stephen; Shahijanian, Fernando; Stewart, Graeme; Atkins, Annette; Ding, Ning; Downes, Michael; Evans, Ronald; Western Clinical School: Westmead Institute for Medical Res; School of Medical Sciences: Pharmacology; Western Clinical School: Medicine (Westmead); Western Clinical School: Westmead Institute for Medical Res; Medicine; Western Clinical School: Westmead Institute for Medical Res; Western Clinical School: Westmead Institute for Medical ResCistromic and genetic evidence that the vitamin D receptor mediates susceptibility to latitude-dependent autoimmune diseases, Genes and Immunity, vol.17, 4, 2016,pp 213-219
2016ERRY Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive sß CellsLiddle, Christopher; Ahmadian, Maryam; Atkins, Annette; Dai, Yang; Downes, Michael; Evans, Ronald; Fang, Sungsoon; Kida, Yasuyuki; Lin, Chun Shi; Tseng, Tiffany W.; Wei, Zong; Yoshihara, Eiji; Yu, Ruth; Western Clinical School: Medicine (Westmead)ERRY Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive sß Cells, Cell Metabolism, vol.23, 4, 2016,pp 622-634
2016ERRY Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive sß CellsLiddle, Christopher; Ahmadian, Maryam; Atkins, Annette; Dai, Yang; Downes, Michael; Evans, Ronald; Fang, Sungsoon; Kida, Yasuyuki; Lin, Chun Shi; Tseng, Tiffany W.; Wei, Zong; Yoshihara, Eiji; Yu, Ruth; Western Clinical School: Medicine (Westmead)ERRY Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive sß Cells, Cell Metabolism, vol.23, 4, 2016,pp 622-634
2011Extrahepatic Cancer Suppresses Nuclear Receptor–Regulated Drug MetabolismClarke, Stephen; Kacevska, Marina; Liddle, Christopher; Robertson, Graham; Sharma, Rohini; Downes, Michael; Evans, Ronald; Concord Clinical School: ANZAC Research Institute; Pharmacy; Western Clinical School: Medicine (Westmead); Concord Clinical School: ANZAC Research Institute; Western Clinical School: Westmead Millennium InstituteExtrahepatic Cancer Suppresses Nuclear Receptor–Regulated Drug Metabolism, Clinical Cancer Research, vol.17, 10, 2011,pp 3170-3180
2012FXR and PXR: Potential therapeutic targets in cholestasisLiddle, Christopher; Downes, Michael; Jonker, Johan; Western Clinical School: Medicine (Westmead)FXR and PXR: Potential therapeutic targets in cholestasis, Journal of Steroid Biochemistry and Molecular Biology, vol.130, 3-5, 2012,pp 147-158
2009Hepatobiliary ABC transporters: physiology, regulation and implications for diseaseLiddle, Christopher; Downes, Michael; Jonker, Johan; Stedman, Catherine; Western Clinical School: Medicine (Westmead)Hepatobiliary ABC transporters: physiology, regulation and implications for disease, Frontiers in Bioscience, vol.14, N/A, 2009,pp 4904-4920
2013Insights into Negative Regulation by the Glucocorticoid Receptor from Genome-wide Profiling of Inflammatory CistromesLiddle, Christopher; Barish, Grant; Downes, Michael; Evans, Ronald M.; Hubner, Norbert; Karunasiri, Malith; Schwalie, Petra; Uhlenhaut, N Henriette; Yu, Ruth; Western Clinical School: Medicine (Westmead)Insights into Negative Regulation by the Glucocorticoid Receptor from Genome-wide Profiling of Inflammatory Cistromes, Molecular Cell, vol.49, 1, 2013,pp 158-171
2015Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistanceCoulter, Sally; Liddle, Christopher; Atkins, Annette; Brenner, David; Downes, Michael; Evans, Ronald; Fang, Sungsoon; Jacinto, Sandra; Khvat, Alexander; Lackey, Denise; Lukasheva, Yelizaveta; Olefsky, Jerrold M; Osborn, Olivia; Perino, Alessia; Reilly, Shannon; Saltiel, Alan R; Schnabl, Bernd; Schoonjans, Kristina; Suh, Jae Myoung; Yoshihara, Eiji; Yu, Elizabeth; Yu, Ruth; School of Medical Sciences: Pharmacology; Western Clinical School: Medicine (Westmead)Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance, Nature Medicine, vol.21, 2, 2015,pp 159-165
2017Metabolic control of regulatory T cell (Treg) survival and function by Lkb1Liddle, Christopher; Atkins, Annette; Downes, Michael; Evans, Ronald; Fan, Weiwei; He, Nanhai; Henriquez, Brian; Yu, Ruth; Zheng, Ye; Westmead Clinical School: MedicineMetabolic control of regulatory T cell (Treg) survival and function by Lkb1, Proceedings of the National Academy of Sciences of the United States of America, vol.114, 47, 2017,pp 12542-12547
2014Metabolic Crosstalk: molecular links between glycogen and lipid metabolism in obesityLiddle, Christopher; Bridges, Dave; Chang, Louise; Cheng, Alan; Downes, Michael; Evans, Ronald; Fisher, Kaleigh; Lin, Jiandie D; Lu, Binbin; Meng, Zhuo-Xian; Saltiel, Alan R; Yang, Yemen; Yu, Ruth; Western Clinical School: Medicine (Westmead)Metabolic Crosstalk: molecular links between glycogen and lipid metabolism in obesity, Diabetes, vol.63, 9, 2014,pp 2935-2948
2012Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signalingCoulter, Sally; Liddle, Christopher; Rao, Renuka; Subramaniam, Nanthakumar; Wilson, Caroline; Atkins, Annette; Downes, Michael; Evans, Ronald; Sherman, Mara; School of Medical Sciences: Pharmacology; Western Clinical School: Medicine (Westmead); Western Clinical School: Medicine (Westmead); School of Medical Sciences: Pharmacology; School of Medical Sciences: PharmacologyMetformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signaling, Cancer Prevention Research, vol.5, 4, 2012,pp 553-561
2005Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury.Liddle, Christopher; Stedman, Catherine; Alvarez, Jacqueline G. A.; Coulter, Sally A.; Downes, Michael; Evans, Ronald M.; Moore, David D.; Sonoda, Junichiro; Western Clinical School: Medicine (Westmead); Clinical SchoolsNuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury., National Academy of Sciences 2005, vol.102,(6),2005,pp 2063-2068
2017PPAR(delta) Promotes Running Endurance by Preserving GlucoseLiddle, Christopher; Atkins, Annette; Auwerx, Johan; Downes, Michael; Evans, Ronald; Fan, Weiwei; He, Mingxiao; Li, Hao; Lin, Chun Shi; Sorrentino, V; Waizenegger, W; Wall, Christopher E.; Yu, Ruth; Western Clinical School: Medicine (Westmead)PPAR(delta) Promotes Running Endurance by Preserving Glucose, Cell Metabolism, vol.25, 5, 2017,pp 1186-1193
2013PPARγ signaling and metabolism: the good, the bad and the futureLiddle, Christopher; Ahmadian, Maryam; Atkins, Annette; Downes, Michael; Evans, Ronald; Hah, Nasun; Suh, Jae Myoung; Western Clinical School: Medicine (Westmead)PPARγ signaling and metabolism: the good, the bad and the future, Nature Medicine, vol.19, 5, 2013,pp 557-566
2005Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites.Liddle, Christopher; Barish, G; Chong, L; Coulter, Sally A.; Downes, Michael; Evans, Ronald M.; Lee, Chih-Hao; Sonoda, Junichiro; Western Clinical School: Medicine (Westmead)Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites., Proceedings of the National Academy of Sciences, vol.102,(6),2005,pp 2198-203