Browsing by Author Double, Kay

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Issue DateTitleAuthor(s)Citation
2017Amyotrophic lateral sclerosis-like superoxide dismutase 1 proteinopathy is associated with neuronal loss in Parkinson's disease brainBall, Helen; Cottam, Veronica; Double, Kay; Genoud, Sian; Halliday, Glenda; Lewis, Simon; Trist, Benjamin; Carmona, Asuncion; Davies, K; De Silva, K; et al, Various; Ortega, Richard; Roudeau, S; Sachdev, Perminder; Smith, B; Troakes, C; Wasinger, Valerie C.; School of Medical Sciences: Pathology; School of Medical Sciences: School of Medical Sciences; School of Medical Sciences: Biomedical Sciences; School of Medical Sciences: Biomedical Sciences; Central Clinical School: Medicine; Central Clinical School: Medicine; School of Medical Sciences: School of Medical SciencesAmyotrophic lateral sclerosis-like superoxide dismutase 1 proteinopathy is associated with neuronal loss in Parkinson's disease brain, Acta Neuropathologica, vol.134, 1, 2017,pp 113-127
2017Analogues of desferrioxamine B designed to attenuate iron-mediated neurodegeneration: synthesis, characterisation and activity in the MPTP-mouse model of Parkinson's diseaseCodd, Rachel; Double, Kay; Gotsbacher, Michael; Telfer, Thomas; Witting, Paul; Finkelstein, David; School of Medical Sciences: Pharmacology; School of Medical Sciences: Biomedical Sciences; School of Medical Sciences: Pharmacology; School of Medical Sciences: Pharmacology; School of Medical Sciences: PathologyAnalogues of desferrioxamine B designed to attenuate iron-mediated neurodegeneration: synthesis, characterisation and activity in the MPTP-mouse model of Parkinson's disease, Metallomics, vol.9, 7, 2017,pp 852-864
2015Comparative Study of Metal Quantification in Neurological Tissue Using Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry Imaging and X-ray Fluorescence MicroscopyDouble, Kay; Billings, Jessica L.; Bohic, Sylvain; Davies, Katherine; Doble, Philip; Finkelstein, David; Hare, Dominic J.; James, Simon A.; School of Medical Sciences: Biomedical SciencesComparative Study of Metal Quantification in Neurological Tissue Using Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry Imaging and X-ray Fluorescence Microscopy, Analytical Chemistry, vol.87, 13, 2015,pp 6639-6645
2016Copper dyshomoeostasis in Parkinson's disease: Implications for pathogenesis and indications for novel therapeuticsDouble, Kay; Chen, Nicholas; Davies, Katherine; Mercer, Julian; School of Medical Sciences: Biomedical SciencesCopper dyshomoeostasis in Parkinson's disease: Implications for pathogenesis and indications for novel therapeutics, Clinical Science, vol.130, 8, 2016,pp 565-574
2016Copper dyshomoeostasis in Parkinson's disease: Implications for pathogenesis and indications for novel therapeuticsDouble, Kay; Chen, Nicholas; Davies, Katherine; Mercer, Julian; School of Medical Sciences: Biomedical SciencesCopper dyshomoeostasis in Parkinson's disease: Implications for pathogenesis and indications for novel therapeutics, Clinical Science, vol.130, 8, 2016,pp 565-574
2014Copper pathology in vulnerable brain regions in Parkinson's diseaseDouble, Kay; Bohic, Sylvain; Carmona, Asuncion; Cottam, V; Davies, Katherine; Finberg, John; Halliday, Glenda; Hare, Dominic; Mercer, Julian; Ortega, Richard; Reyes, S; School of Medical Sciences: Biomedical SciencesCopper pathology in vulnerable brain regions in Parkinson's disease, Neurobiology of Aging, vol.35, 4, 2014,pp 858-866
2016Decline in proliferation and immature neuron markers in the human subependymal zone during aging: Relationship to EGF- and FGF-related transcriptsDouble, Kay; Barry, Guy; Fung, Samantha; Halliday, Glenda; Webster, Maree J.; Weickert, Cynthia; Weissleder, Christin; Wong, Matthew; School of Medical Sciences: Biomedical SciencesDecline in proliferation and immature neuron markers in the human subependymal zone during aging: Relationship to EGF- and FGF-related transcripts, Frontiers in Aging Neuroscience, vol.8, NOV, 2016,pp 1-12
2017Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markersBall, Helen; Double, Kay; Mathews, K; Allen, Katherine M.; Boerrigter, Danny; Weickert, Cynthia Shannon; School of Medical Sciences: Pathology; School of Medical Sciences: Biomedical Sciences; School of Medical Sciences: Biomedical SciencesEvidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers, Aging Cell, vol.16, 5, 2017,pp 1195-1199
2017Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson's diseaseDouble, Kay; Biggs, Beverley-Ann; Cardoso, Barbara; Finkelstein, David; Hare, David; Raven, Erika; Szymlek-Gay, Ewa; School of Medical Sciences: Biomedical SciencesExcessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson's disease, NPJ Parkinson's Disease, vol.3, 1, 2017,pp 1-5
2014Hand function is impaired in healthy older adults at risk of Parkinson's diseaseDouble, Kay; Hayes, Michael; Berg, D; Faulkner, Patrick L; Gandevia, Simon; Godau, Jana; Haberfield, Miranda; Piguet, Oliver; Rae, Caroline; Taylor, Janet L; Todd, Gabrielle; Wilcox, Robert; School of Medical Sciences: Biomedical Sciences; Concord Clinical School: MedicineHand function is impaired in healthy older adults at risk of Parkinson's disease, Journal of Neural Transmission, vol.121, 11, 2014,pp 1377-1386
2014Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson's diseaseDouble, Kay; Bye, Chris; Hall, Helene; Halliday, Glenda; Kirik, Deniz; Landeck, Natalie; Leanza, Giampiero; Reyes, Stefanie; Thompson, L; School of Medical Sciences: Biomedical SciencesHippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson's disease, Brain, vol.137, 9, 2014,pp 2493-2508
2016Iron and dopamine: A toxic coupleDouble, Kay; Hare, Dominic J.; School of Medical Sciences: Biomedical SciencesIron and dopamine: A toxic couple, Brain, vol.139, 4, 2016,pp 1026-1035
2012L-DOPA is incorporated into brain proteins of patients treated for Parkinson's disease, inducing toxicity in human neuroblastoma cells in vitroRowe, Anthony; Chan, Sandra; Double, Kay; Dunlop, Rachael; Rodgers, Kenneth J.; PharmacyL-DOPA is incorporated into brain proteins of patients treated for Parkinson's disease, inducing toxicity in human neuroblastoma cells in vitro, Experimental Neurology, vol.238, 1, 2012,pp 29-37
2017Putative presynaptic dopamine dysregulation in schizophrenia is supported by molecular evidence from post-mortem human midbrainDouble, Kay; McCrossin, Toni; Stevens, Julia; Halliday, Glenda; Owens, Samantha; Purves-Tyson, Tertia; Rothmond, Debora A.; Weickert, Cynthia Shannon; School of Medical Sciences: Biomedical Sciences; Medicine; School of Medical Sciences: PathologyPutative presynaptic dopamine dysregulation in schizophrenia is supported by molecular evidence from post-mortem human midbrain, Translational Psychiatry, vol.7, 1, 2017,pp 1-12
2017Subcellular compartmentalisation of copper, iron, manganese, and zinc in the Parkinson's disease brainBall, Helen; Double, Kay; Genoud, Sian; Halliday, Glenda; Lewis, Simon; Gunn, Adam; Hare, Dominic; Roberts, Blaine R.; School of Medical Sciences: Pathology; School of Medical Sciences: Biomedical Sciences; School of Medical Sciences: Biomedical Sciences; Central Clinical School: Medicine; Central Clinical School: MedicineSubcellular compartmentalisation of copper, iron, manganese, and zinc in the Parkinson's disease brain, Metallomics, vol.9, 10, 2017,pp 1447-1455
2016Tension-referenced measures of gastrocnemius slack length and stiffness in Parkinson's diseaseBurne, John; Diong, Joanna; Double, Kay; Tan, Benedict; School of Medical Sciences: Biomedical Sciences; School of Medical Sciences: Biomedical Sciences; School of Medical Sciences: Biomedical SciencesTension-referenced measures of gastrocnemius slack length and stiffness in Parkinson's disease, Movement Disorders, vol.31, 12, 2016,pp 1914-1918
2015Testosterone attenuates and the selective estrogen receptor modulator, raloxifene, potentiates amphetamine-induced locomotion in male ratsDesai, Reena; Double, Kay; Handelsman, David; Allen, Katherine M.; Boerrigter, Danny; Djunaidi, Vanezha; Karl, Tim; Purves-Tyson, Tertia; Weickert, Cynthia Shannon; Zavitsanou, Katerina; Concord Clinical School: ANZAC Research Institute; School of Medical Sciences: Biomedical Sciences; Concord Clinical School: ANZAC Research InstituteTestosterone attenuates and the selective estrogen receptor modulator, raloxifene, potentiates amphetamine-induced locomotion in male rats, Hormones and Behavior, vol.70, N/A, 2015,pp 73-84
2014Testosterone Induces Molecular Changes in Dopamine Signaling Pathway Molecules in the Adolescent Male Rat Nigrostriatal PathwayDesai, Reena; Double, Kay; Handelsman, David; Owens, Samantha; Purves-Tyson, Tertia; Weickert, Cynthia Shannon; Concord Clinical School: ANZAC Research Institute; School of Medical Sciences: Biomedical Sciences; Concord Clinical School: ANZAC Research InstituteTestosterone Induces Molecular Changes in Dopamine Signaling Pathway Molecules in the Adolescent Male Rat Nigrostriatal Pathway, PLoS One, vol.9, 3, 2014,pp 1-12
2015Upper limb function is normal in patients with restless legs syndrome (Willis-Ekbom Disease)Double, Kay; Grunstein, Ron (Ronald); Yee, Brendon; Bulathsinhala, Tarsha; Faulkner, Patrick L; Haberfield, Miranda; Hayes, Michael; Rae, Caroline; Todd, Gabrielle; Wilcox, Robert; School of Medical Sciences: Biomedical Sciences; Central Clinical School: Woolcock Inst. of Medical Research; Central Clinical School: Woolcock Inst. of Medical ResearchUpper limb function is normal in patients with restless legs syndrome (Willis-Ekbom Disease), Clinical Neurophysiology, vol.126, 4, 2015,pp 736-742
2015Using Sepia melanin as a PD model to describe the binding characteristics of neuromelanin - A critical reviewDouble, Kay; Gerber, Jacobus; Schroeder, Rhiannon L; School of Medical Sciences: Biomedical SciencesUsing Sepia melanin as a PD model to describe the binding characteristics of neuromelanin - A critical review, Journal of Chemical Neuroanatomy, vol.64-65, N/A, 2015,pp 20-32