Browsing by Author Brown, Melissa

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Issue DateTitleAuthor(s)Citation
2007Active export proteins mediating drug resistance in staphylococciBrown, Melissa; Hassan, Karl; Skurray, Ronald; Biological Sciences; Biological Sciences; Biological SciencesActive export proteins mediating drug resistance in staphylococci, Journal of Molecular Microbiology and Biotechnology, vol.12,(3-4),2007,pp 180-196
2008Analysis of tryptophan residues in the staphylococcal multidrug transporter QacA reveals long-distance functional associations of residues on opposite sides of the membraneBrown, Melissa; Hassan, Karl; Skurray, Ronald; Souhani, Talal; Biological Sciences; Biological Sciences; Biological Sciences; Biological SciencesAnalysis of tryptophan residues in the staphylococcal multidrug transporter QacA reveals long-distance functional associations of residues on opposite sides of the membrane, Journal of Bacteriology, vol.190, 7, 2008,pp 2441-2449
2009Arabidopsis phospholipase D as an initiator of cytoskeleton-mediated signalling to fundamental cellular processesBrown, Melissa; Day, David; Ho, Angela; Marc, Jan; Biological Sciences; Biological Sciences; Biological Sciences; Biological SciencesArabidopsis phospholipase D as an initiator of cytoskeleton-mediated signalling to fundamental cellular processes, Functional Plant Biology: an international journal of plant function, vol.36, N/A,pp 190-198
2009Biochemical Characterization of the Multidrug Regulator QacR Distinguishes Residues That Are Crucial to Multidrug Binding and Induction of qacA TranscriptionBrown, Melissa; Hardie, Kate; Sharbeen, George; Skurray, Ronald; Theis, Torsten; Biological Sciences; Biological Sciences; Biological Sciences; Biological Sciences; Biological SciencesBiochemical Characterization of the Multidrug Regulator QacR Distinguishes Residues That Are Crucial to Multidrug Binding and Induction of qacA Transcription, Biochemistry, vol.48,(41),2009,pp 9794-9800
2006Functional effects of intramembranous proline substitutions in the staphylococcal multidrug transporter QacABrown, Melissa; Galea, Melanie; Hassan, Karl; Mitchell, Bernadette; Skurray, Ronald; Wu, Jingqin; Biological Sciences; Biological Sciences; Biological Sciences; Pharmacy; Biological Sciences; Biological SciencesFunctional effects of intramembranous proline substitutions in the staphylococcal multidrug transporter QacA, FEMS Microbiology Letters, vol.263,(1),2006,pp 76-85
2007Global regulation of survival functions in conjugative Staphylococcal multiresistance plasmidsBrown, Melissa; Firth, Neville; Guan, Ting-Rui; Jensen, Slade; Kwong, Stephen; Skurray, Ronald; Berg, T; Biological Sciences; Biological Sciences; School of Public Health: Public Health; Biological Sciences; Biological Sciences; Biological SciencesGlobal regulation of survival functions in conjugative Staphylococcal multiresistance plasmids, Global regulation of survival functions in conjugative Staphylococcal multiresistance plasmids, vol.57,(57),2007,pp 197-198
2006Glycine-Rich Transmembrane Helix 10 in the Staphylococcal Tetracycline Transporter TetA(K) Lines a Solvent-Accessible ChannelBrown, Melissa; Gibson, Joanne; Hassan, Karl; Robinson, Katie; Skurray, Ronald; Smith, Alison; Biological Sciences; Biological Sciences; Biological Sciences; Biological Sciences; Biological Sciences; Biological SciencesGlycine-Rich Transmembrane Helix 10 in the Staphylococcal Tetracycline Transporter TetA(K) Lines a Solvent-Accessible Channel, Biochemistry 2005, vol.45,(51),2006,pp 15661-15669
2007Identification of suitable internal controls to study expression of a Staphylococcus aureus multidrug resistance system by quantitative real-time PCRBrown, Melissa; Skurray, Ronald; Theis, Torsten; Biological Sciences; Biological Sciences; Biological SciencesIdentification of suitable internal controls to study expression of a Staphylococcus aureus multidrug resistance system by quantitative real-time PCR, Journal of Microbiological Methods, vol.70,(2),2007,pp 355-362
2003Interactions of the QacR multidrug-binding protein with structurally diverse ligands: Implications for the evolution of the binding pocketBrown, Melissa; Grkovic, Steve; Hardie, Kate; Skurray, Ronald; Biological Sciences; Central Clinical School: Medicine; Biological Sciences; Biological SciencesInteractions of the QacR multidrug-binding protein with structurally diverse ligands: Implications for the evolution of the binding pocket, Biochemistry, vol.42,(51),2003,pp 15226-15236
2006Low-level resistance of Staphylococcus aureus to thrombin-induced platelet microbicidal protein 1 in vitro associated with qacA gene carriage is independent of multidrug efflux pump activityBrown, Melissa; Grkovic, Steve; Skurray, Ronald; Bayer, A; Jones, T; Kupferwasser, L; Mukhopadhay, K; Yeaman, M; Biological Sciences; Central Clinical School: Medicine; Biological SciencesLow-level resistance of Staphylococcus aureus to thrombin-induced platelet microbicidal protein 1 in vitro associated with qacA gene carriage is independent of multidrug efflux pump activity, Antimicrobial Agents and Chemotherapy, vol.50,(7),2006,pp 2448-2454
2006Microbial drug efflux proteins of the major facilitator superfamilyBrown, Melissa; Skurray, Ronald; Xu, Zhiqiang; Benedetti, Giulia; Bettaney, Kim; Bill, Roslyn; Butaye, Patrick; Henderson, Peter; Herbert, Richard; Hoyle, Christopher; Langton, Kate; Meuller, Johan; Morrison, Scott; O'Reilly, John; Palmer, Sarah; Paulsen, Ian; Pos, Martin; Ren, Qinghu; Rutherford, Nicholas; Saidijam, Massoud; Szakonyi, Gerda; Walravens, Karl; Ward, Alison; Biological Sciences; Biological Sciences; Biological SciencesMicrobial drug efflux proteins of the major facilitator superfamily, Current Drug Targets, vol.7,(7),2006,pp 793-811
2009Optimized production and analysis of the staphylococcal multidrug efflux protein QacABrown, Melissa; Hassan, Karl; Skurray, Ronald; Xu, Zhiqiang; Brennan, Richard G; Watkins, Ryan; Biological Sciences; Biological Sciences; Biological Sciences; Biological SciencesOptimized production and analysis of the staphylococcal multidrug efflux protein QacA, Protein Expression and Purification, vol.64, N/A, 2009,pp 118-124
2008QacR-cation recognition is mediated by a redundancy of residues capable of charge neutralizationBrown, Melissa; Peters, Kate; Skurray, Ronald; Brennan, Richard G; Schumacher, Maria A; Schuman, Jason T.; Biological Sciences; Biochemistry; Biological SciencesQacR-cation recognition is mediated by a redundancy of residues capable of charge neutralization, Biochemistry, vol.47,(31),2008,pp 8122-8129
2002Regulation of bacterial drug export systemsBrown, Melissa; Grkovic, Steve; Skurray, Ronald; Biological Sciences; Central Clinical School: Medicine; Biological SciencesRegulation of bacterial drug export systems, Microbiology and Molecular Biology Reviews, vol.66,(4),2002,pp 671-701
2006Role of transmembrane segment 10 in efflux mediated by the staphylococcal multidrug transport protein QacABrown, Melissa; O'Rourke, Brendon; Skurray, Ronald; Xu, Zhiqiang; Biological Sciences; Biological Sciences; Biological Sciences; Biological SciencesRole of transmembrane segment 10 in efflux mediated by the staphylococcal multidrug transport protein QacA, Journal of Biological Chemistry, vol.281,(2),2006,pp 792-799
2011A single acidic residue can guide binding site selection but does not govern QaCR cationic-drug affinityBrown, Melissa; Peters, Kate; Skurray, Ronald; Brennan, Richard G; Brooks, B.E.; Schumacher, Maria A; Biological Sciences; Biochemistry; Biological SciencesA single acidic residue can guide binding site selection but does not govern QaCR cationic-drug affinity, PLoS One, vol.6, 1, Article number e15974, 2011,pp e15974-e15974
2003Stable low-copy-number Staphylococcus aureus shuttle vectorsBrown, Melissa; Firth, Neville; Grkovic, Steve; Hardie, Kate; Skurray, Ronald; Biological Sciences; Biological Sciences; Central Clinical School: Medicine; Biological Sciences; Biological SciencesStable low-copy-number Staphylococcus aureus shuttle vectors, Microbiology, vol.149,(2003),2003,pp 785-794
2009The Staphylococcus aureus pSK41 plasmid-encoded ArtA protein is a master regulator of plasmid transmission genes and contains a RHH motif used in alternate DNA-binding modesBerg, Tracey; Firth, Neville; Guan, Fiona; Jensen, Slade; Kwong, Stephen; Skurray, Ronald; Brown, Melissa; Ni, Lisheng; Schumacher, Maria A; Tonthat, Nam Ky; Biological Sciences; Biological Sciences; Biological Sciences; Biological Sciences; Biological Sciences; Biological SciencesThe Staphylococcus aureus pSK41 plasmid-encoded ArtA protein is a master regulator of plasmid transmission genes and contains a RHH motif used in alternate DNA-binding modes, Nucleic Acids Research, vol.37, N/A,pp 6970-6983
2002Structural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacRBrown, Melissa; Grkovic, Steve; Skurray, Ronald; Brennan, Richard G.; Miller, Marshall C.; Schumacher, Maria A.; Biological Sciences; Central Clinical School: Medicine; Biological SciencesStructural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacR, The EMBO Journal, vol.21, 5,pp 1210-1218
2002Structure, function and regulation of the Staphylococcal multidrug efflux protein QacA.Brown, Melissa; Skurray, Ronald; Biological Sciences; Biological SciencesStructure, function and regulation of the Staphylococcal multidrug efflux protein QacA. in Microbial Multidrug Efflux, Staempfli Publishers Ltd, 2002, pp. 49-66