Browsing by Author Balle, Thomas

Jump to: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
or enter first few letters:  
Showing results 1 to 20 of 32  next >
Issue DateTitleAuthor(s)Citation
20145-(Piperidin-4-yl)-3-Hydroxypyrazole: A Novel Scaffold for Probing the Orthosteric gamma-Aminobutyric Acid Type A Receptor Binding SiteBalle, Thomas; Sorensen, Troels; Frolund, Bente; Jensen, Anders; Kongstad, Kenneth T; Krall, Jacob; Nielsen, Birgitte; Pharmacy; Pharmacy5-(Piperidin-4-yl)-3-Hydroxypyrazole: A Novel Scaffold for Probing the Orthosteric gamma-Aminobutyric Acid Type A Receptor Binding Site, ChemMedChem: chemistry enabling drug discovery, vol.9, 11, 2014,pp 2475-2485
2015Acetylcholine-Binding Protein Engineered to Mimic the alpha4-alpha4 Binding Pocket in alpha4beta2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and ActivityAhring, Joergen Phillip; Balle, Thomas; Olsen, Jeppe; Gajhede, Michael; Kastrup, Jette Sandholm; Krintel, Christian; Shahsavar, Azadeh; Pharmacy; Pharmacy; PharmacyAcetylcholine-Binding Protein Engineered to Mimic the alpha4-alpha4 Binding Pocket in alpha4beta2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity, Molecular Pharmacology, vol.88, 4, 2015,pp 697-707
2015Conformationally restrained carbamoylcholine homologues. Synthesis, pharmacology at neuronal nicotinic acetylcholine receptors and biostructural considerationsBalle, Thomas; De La Fuente Revenga, Mario; Frølund, Bente; Jensen, Anders; PharmacyConformationally restrained carbamoylcholine homologues. Synthesis, pharmacology at neuronal nicotinic acetylcholine receptors and biostructural considerations, European Journal of Medicinal Chemistry, vol.102, N/A, 2015,pp 352-362
2012Covalent attachment of antagonists to the a7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimidesAbsalom, Nathan; Collins (Chebib), Mary; Ambrus, Joseph; Balle, Thomas; Halliday, Jill; Harpsoe, Kasper; Kanizaj, Nicholas; McLeod, Malcolm; Pharmacy; PharmacyCovalent attachment of antagonists to the a7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides, Chemical Communications, vol.48, 53, 2012,pp 6699-6701
2013Covalent trapping of methyllycaconitine at the alpha4-alpha4 interface of the apha4beta2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealedAbsalom, Nathan; Balle, Thomas; Collins (Chebib), Mary; Karim, Nasiara; Qudah, Taima; Quek, Gracia; von Arenstorff, Ida; Ambrus, Joseph; Harpsøe, Kasper; Lewis, Trevor M.; McLeod, Malcolm; Pharmacy; Pharmacy; Pharmacy; Pharmacy; Pharmacy; Pharmacy; PharmacyCovalent trapping of methyllycaconitine at the alpha4-alpha4 interface of the apha4beta2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed, The Journal of Biological Chemistry, vol.288, 37, 2013,pp 26521-26532
2013Design, Synthesis, and Biological Evaluation of Erythrina Alkaloid Analogues as Neuronal Nicotinic Acetylcholine Receptor AntagonistsBalle, Thomas; Andersen, Jacob; Andreasen, Jesper; Borch, Morten; Crestey, Francois; Jensen, Anders; Kristensen, Jesper; PharmacyDesign, Synthesis, and Biological Evaluation of Erythrina Alkaloid Analogues as Neuronal Nicotinic Acetylcholine Receptor Antagonists, Journal of Medicinal Chemistry, vol.56, 23, 2013,pp 9673-9682
2013Discovery of novel a1-adrenoceptor ligands based on the antipsychotic sertindole suitable for labeling as PET ligandsBalle, Thomas; Bang-Andersen, Benny; Christoffersen, Claus T; Jensen, Klaus Gjervig; Jorgensen, Morten; Jorgensen, Pernille; PharmacyDiscovery of novel a1-adrenoceptor ligands based on the antipsychotic sertindole suitable for labeling as PET ligands, Bioorganic and Medicinal Chemistry, vol.21, 1, 2013,pp 196-204
2015Engineered alpha4beta2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity alpha4-alpha4 interfaceAhring, Joergen Phillip; Balle, Thomas; Collins, Mary; Indurthi Venkata, Dinesh; Olsen, Jeppe; Gajhede, Michael; Kastrup, Jette Sandholm; Nielsen, Elsebet Ostergaard; Pedersen, Martin H.F.; Peters, Dan; Rohde, Line A.; Shahsavar, Azadeh; Pharmacy; Pharmacy; Pharmacy; Pharmacy; PharmacyEngineered alpha4beta2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity alpha4-alpha4 interface, Neuropharmacology, vol.92, N/A, 2015,pp 135-145
2015Exploration of the molecular architecture of the orthosteric binding site in the alpha4beta2 nicotinic acetylcholine receptor with analogs of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) and 1-(pyridin-3-yl)-1,4-diazepaneBalle, Thomas; Liu, Jun; Sorensen, Troels; Bach, Tinna; Blaazer, Antoni; Della Volpe, Serena; Frolund, Bente; Jensen, Anders; Petersen, Jette; Van Muijlwijk-Koezen, Jacqueline; Pharmacy; Pharmacy; PharmacyExploration of the molecular architecture of the orthosteric binding site in the alpha4beta2 nicotinic acetylcholine receptor with analogs of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) and 1-(pyridin-3-yl)-1,4-diazepane, European Journal of Medicinal Chemistry, vol.102, N/A, 2015,pp 425-444
2013Exploring the Orthosteric Binding Site of the y-Aminobutyric Acid Type A Receptor Using 4-(Piperidin-4-yl)-1-hydroxypyrazoles 3- or 5-Imidazolyl Substituted: Design, Synthesis, and Pharmacological EvaluationBalle, Thomas; Sorensen, Troels; Frolund, Bente; Jensen, Anders; Jensen, Claus H; Krall, Jacob; Nielsen, Birgitte; Sander, Tommy; Pharmacy; PharmacyExploring the Orthosteric Binding Site of the y-Aminobutyric Acid Type A Receptor Using 4-(Piperidin-4-yl)-1-hydroxypyrazoles 3- or 5-Imidazolyl Substituted: Design, Synthesis, and Pharmacological Evaluation, Journal of Medicinal Chemistry, vol.56, 16, 2013,pp 6536-6540
2015From Shellfish Poisoning to NeuroscienceBalle, Thomas; Shahsavar, Azadeh; PharmacyFrom Shellfish Poisoning to Neuroscience, Structure, vol.23, 6, 2015,pp 979-980
2011G protein-and agonist-bound serotonin 5-HT2A receptor model activated by steered molecular dynamics simulationsBalle, Thomas; Gloriam, David E; Isberg, Vignir; Jorgensen, Flemming Steen; Sander, Tommy; PharmacyG protein-and agonist-bound serotonin 5-HT2A receptor model activated by steered molecular dynamics simulations, Journal of Chemical Information and Modeling, vol.51, 2, 2011,pp 315-325
2015GABAA receptor partial agonists and antagonists: Structure, binding mode, and pharmacologyBalle, Thomas; Sorensen, Troels; Frolund, Bente; Krall, Jacob; Kristiansen, Uffe; Krogsgaard-Larsen, Niels; Krogsgaard-Larsen, Povl; Pharmacy; PharmacyGABAA receptor partial agonists and antagonists: Structure, binding mode, and pharmacology, Advances in Pharmacology, vol.72, N/A, 2015,pp 201-227
2015Innate Immunity and Inflammation Post-Stroke: An alpha7-Nicotinic Agonist PerspectiveBalle, Thomas; Clarkson, Andrew; Collins, Mary; Neumann, Silke; Shields, Nicholas J; Pharmacy; Pharmacy; PharmacyInnate Immunity and Inflammation Post-Stroke: An alpha7-Nicotinic Agonist Perspective, International Journal of Molecular Sciences, vol.16, 12, 2015,pp 29029-29046
2016Ligand binding at the 4-4 agonist-binding site of the 42 nAChR triggers receptor activation through a pre-activated conformational stateAbsalom, Nathan Luke; Ahring, Joergen Phillip; Balle, Thomas; Collins, Mary; Indurthi Venkata, Dinesh; Lewis, Trevor; Pharmacy; Pharmacy; Pharmacy; Pharmacy; PharmacyLigand binding at the 4-4 agonist-binding site of the 42 nAChR triggers receptor activation through a pre-activated conformational state, PloS One, vol.11, 8, 2016,pp 1-20
2013Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptorsBalle, Thomas; Ahring, Philip; Dyhring, Tino; Gajhede, Michael; Hald, Helle; Harpsoe, Kasper; Jensen, Marianne; Kastrup, Jette Sandholm; Nielsen, Elsebet; Peters, Dan; Timmermann, Daniel; PharmacyMolecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors, JBC Papers in Press, vol.288, 4, 2013,pp 2559-2570
2014Molecular Recognition of the Neurotransmitter Acetylcholine by an Acetylcholine Binding Protein Reveals Determinants of Binding to Nicotinic Acetylcholine ReceptorsAhring, Joergen Phillip; Balle, Thomas; Gajhede, Michael; Kastrup, Jette Sandholm; Olsen, Jeppe; Pharmacy; PharmacyMolecular Recognition of the Neurotransmitter Acetylcholine by an Acetylcholine Binding Protein Reveals Determinants of Binding to Nicotinic Acetylcholine Receptors, PloS One, vol.9, 3, 2014,pp 1-8
2011New insights into the GABAA receptor structure and orthosteric ligand binding: Receptor modeling guided by experimental dataBalle, Thomas; Bruun, Anne Techau; Frolund, Bente; Ivanov, Ivaylo; McCammon, James Andrew; Sander, Tommy; PharmacyNew insights into the GABAA receptor structure and orthosteric ligand binding: Receptor modeling guided by experimental data, Proteins: Structure, Function, and Bioinformatics, vol.79, N/A, 2011,pp 1458-1477
2015Pinnatoxins E, F and G target multiple nicotinic receptor subtypesBalle, Thomas; Collins, Mary; Indurthi Venkata, Dinesh; Runder-Varga, Vanda; Hellyer, Shane D.; Kerr, Steven; Rhodes, Lesley; Selwood, Andrew I; Tyndall, Joel; Pharmacy; Pharmacy; Pharmacy; PharmacyPinnatoxins E, F and G target multiple nicotinic receptor subtypes, Journal of Neurochemistry, vol.135, 3, 2015,pp 479-491
2014Probing the Orthosteric Binding Site of GABAA Receptors with Heterocyclic GABA Carboxylic Acid Bioisosteres.Balle, Thomas; Bergmann, Rikke; Frolund, Bente; Krogsgarrd-Larsen, Povl; Petersen, Jette; PharmacyProbing the Orthosteric Binding Site of GABAA Receptors with Heterocyclic GABA Carboxylic Acid Bioisosteres., Neurochemical Research, vol.39, 6, 2014,pp 1005-1015