Browsing by Author Ahring, Joergen Phillip

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Showing results 1 to 15 of 15
Issue DateTitleAuthor(s)Citation
2015Acetylcholine-Binding Protein Engineered to Mimic the alpha4-alpha4 Binding Pocket in alpha4beta2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and ActivityAhring, Joergen Phillip; Balle, Thomas; Olsen, Jeppe; Gajhede, Michael; Kastrup, Jette Sandholm; Krintel, Christian; Shahsavar, Azadeh; Pharmacy; Pharmacy; PharmacyAcetylcholine-Binding Protein Engineered to Mimic the alpha4-alpha4 Binding Pocket in alpha4beta2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity, Molecular Pharmacology, vol.88, 4, 2015,pp 697-707
2015Engineered alpha4beta2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity alpha4-alpha4 interfaceAhring, Joergen Phillip; Balle, Thomas; Collins, Mary; Indurthi Venkata, Dinesh; Olsen, Jeppe; Gajhede, Michael; Kastrup, Jette Sandholm; Nielsen, Elsebet Ostergaard; Pedersen, Martin H.F.; Peters, Dan; Rohde, Line A.; Shahsavar, Azadeh; Pharmacy; Pharmacy; Pharmacy; Pharmacy; PharmacyEngineered alpha4beta2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity alpha4-alpha4 interface, Neuropharmacology, vol.92, N/A, 2015,pp 135-145
2015GABAA α5 subunit-containing receptors do not contribute to reversal of inflammatory-induced spinal sensitization as indicated by the unique selectivity profile of the GABAA receptor allosteric modulator NS16085Ahring, Joergen Phillip; Garcia de Lucas, A; Larsen, Jennifer; Lopez-Garcia, Jose Antonio; Mirza, Naheed; Munro, Gordon; Rivera-Arconada, Ivan; PharmacyGABAA α5 subunit-containing receptors do not contribute to reversal of inflammatory-induced spinal sensitization as indicated by the unique selectivity profile of the GABAA receptor allosteric modulator NS16085, Biochemical Pharmacology, vol.93, 3, 2015,pp 370-379
2016High and low GABA sensitivity alpha4beta2delta GABAA receptors are expressed in Xenopus laevis oocytes with divergent stoichiometriesAbsalom, Nathan Luke; Ahring, Joergen Phillip; Collins, Mary; Hartiadi, Leonny Yulita; Pharmacy; Pharmacy; Pharmacy; PharmacyHigh and low GABA sensitivity alpha4beta2delta GABAA receptors are expressed in Xenopus laevis oocytes with divergent stoichiometries, Biochemical Pharmacology, vol.103, N/A, 2016,pp 98-108
2016High and low GABA sensitivity alpha4beta2delta GABAA receptors are expressed in Xenopus laevis oocytes with divergent stoichiometriesAbsalom, Nathan Luke; Ahring, Joergen Phillip; Collins, Mary; Hartiadi, Leonny Yulita; Pharmacy; Pharmacy; Pharmacy; PharmacyHigh and low GABA sensitivity alpha4beta2delta GABAA receptors are expressed in Xenopus laevis oocytes with divergent stoichiometries, Biochemical Pharmacology, vol.103, N/A, 2016,pp 98-108
2016Ligand binding at the 4-4 agonist-binding site of the 42 nAChR triggers receptor activation through a pre-activated conformational stateAbsalom, Nathan Luke; Ahring, Joergen Phillip; Balle, Thomas; Collins, Mary; Indurthi Venkata, Dinesh; Lewis, Trevor; Pharmacy; Pharmacy; Pharmacy; Pharmacy; PharmacyLigand binding at the 4-4 agonist-binding site of the 42 nAChR triggers receptor activation through a pre-activated conformational state, PloS One, vol.11, 8, 2016,pp 1-20
2014Molecular Recognition of the Neurotransmitter Acetylcholine by an Acetylcholine Binding Protein Reveals Determinants of Binding to Nicotinic Acetylcholine ReceptorsAhring, Joergen Phillip; Balle, Thomas; Gajhede, Michael; Kastrup, Jette Sandholm; Olsen, Jeppe; Pharmacy; PharmacyMolecular Recognition of the Neurotransmitter Acetylcholine by an Acetylcholine Binding Protein Reveals Determinants of Binding to Nicotinic Acetylcholine Receptors, PloS One, vol.9, 3, 2014,pp 1-8
2016NS383 Selectively Inhibits Acid-Sensing Ion Channels Containing 1a and 3 Subunits to Reverse Inflammatory and Neuropathic Hyperalgesia in RatsAhring, Joergen Phillip; Christensen, Jeppe; Dam, Eva; Demnitz, Joachim; Dyhring, Tino; Erichsen, Helle; Munro, Gordon; PharmacyNS383 Selectively Inhibits Acid-Sensing Ion Channels Containing 1a and 3 Subunits to Reverse Inflammatory and Neuropathic Hyperalgesia in Rats, CNS Neuroscience and Therapeutics, vol.22, 2, 2016,pp 135-145
2016A pharmacological assessment of agonists and modulators at (alpha)4(beta)2(upsilon)2 and (alpha)4(beta)2(gamma) GABAA receptors: The challenge in comparing apples with orangesAbsalom, Nathan Luke; Ahring, Joergen Phillip; Collins, Mary; Hartiadi, Leonny Yulita; Bang, Line; Jensen, Marianne Lerbech; Strobaek, Dorte; Pharmacy; Pharmacy; Pharmacy; PharmacyA pharmacological assessment of agonists and modulators at (alpha)4(beta)2(upsilon)2 and (alpha)4(beta)2(gamma) GABAA receptors: The challenge in comparing apples with oranges, Pharmacological Research, vol.111, N/A, 2016,pp 563-576
2016A pharmacological assessment of agonists and modulators at (alpha)4(beta)2(upsilon)2 and (alpha)4(beta)2(gamma) GABAA receptors: The challenge in comparing apples with orangesAbsalom, Nathan Luke; Ahring, Joergen Phillip; Collins, Mary; Hartiadi, Leonny Yulita; Bang, Line; Jensen, Marianne Lerbech; Strobaek, Dorte; Pharmacy; Pharmacy; Pharmacy; PharmacyA pharmacological assessment of agonists and modulators at (alpha)4(beta)2(upsilon)2 and (alpha)4(beta)2(gamma) GABAA receptors: The challenge in comparing apples with oranges, Pharmacological Research, vol.111, N/A, 2016,pp 563-576
2016A pharmacological characterization of GABA, THIP and DS2 at binary alpha4Beta3 and Beta3delta receptors: GABA activates Beta3delta receptors via the Beta3(+)delta(-) interfaceAbsalom, Nathan Luke; Ahring, Joergen Phillip; Collins, Mary; Hanrahan, Jane; Lee, Ho Joon; van Nieuwenhuijzen, Pieternel (Petra); Pharmacy; Pharmacy; Pharmacy; Pharmacy; Pharmacy; PharmacyA pharmacological characterization of GABA, THIP and DS2 at binary alpha4Beta3 and Beta3delta receptors: GABA activates Beta3delta receptors via the Beta3(+)delta(-) interface, Brain Research, vol.1644, N/A, 2016,pp 222-230
2016A pharmacological characterization of GABA, THIP and DS2 at binary alpha4Beta3 and Beta3delta receptors: GABA activates Beta3delta receptors via the Beta3(+)delta(-) interfaceAbsalom, Nathan Luke; Ahring, Joergen Phillip; Collins, Mary; Hanrahan, Jane; Lee, Ho Joon; van Nieuwenhuijzen, Pieternel (Petra); Pharmacy; Pharmacy; Pharmacy; Pharmacy; Pharmacy; PharmacyA pharmacological characterization of GABA, THIP and DS2 at binary alpha4Beta3 and Beta3delta receptors: GABA activates Beta3delta receptors via the Beta3(+)delta(-) interface, Brain Research, vol.1644, N/A, 2016,pp 222-230
2014Structural and Functional Studies of the Modulator NS9283 Reveal Agonist-like Mechanism of Action at a4B2 Nicotinic Acetylcholine ReceptorsAhring, Joergen Phillip; Balle, Thomas; Olsen, Jeppe; Gajhede, Michael; Kastrup, Jette Sandholm; Pharmacy; Pharmacy; PharmacyStructural and Functional Studies of the Modulator NS9283 Reveal Agonist-like Mechanism of Action at a4B2 Nicotinic Acetylcholine Receptors, The Journal of Biological Chemistry, vol.289, 36, 2014,pp 24911-24921
2016Zolpidem is a potent stoichiometry-selective modulator of (alpha)1(beta)3 GABAA receptors: evidence of a novel benzodiazepine site in the (alpha)1-(alpha)1 interfaceAbsalom, Nathan Luke; Ahring, Joergen Phillip; Che Has, Ahmad; Clarkson, Andrew; Collins, Mary; van Nieuwenhuijzen, Pieternel (Petra); Pharmacy; Pharmacy; Pharmacy; Pharmacy; Pharmacy; PharmacyZolpidem is a potent stoichiometry-selective modulator of (alpha)1(beta)3 GABAA receptors: evidence of a novel benzodiazepine site in the (alpha)1-(alpha)1 interface, Scientific Reports, vol.6, N/A, 2016,pp 1-12
2016Zolpidem is a potent stoichiometry-selective modulator of (alpha)1(beta)3 GABAA receptors: evidence of a novel benzodiazepine site in the (alpha)1-(alpha)1 interfaceAbsalom, Nathan Luke; Ahring, Joergen Phillip; Che Has, Ahmad; Clarkson, Andrew; Collins, Mary; van Nieuwenhuijzen, Pieternel (Petra); Pharmacy; Pharmacy; Pharmacy; Pharmacy; Pharmacy; PharmacyZolpidem is a potent stoichiometry-selective modulator of (alpha)1(beta)3 GABAA receptors: evidence of a novel benzodiazepine site in the (alpha)1-(alpha)1 interface, Scientific Reports, vol.6, N/A, 2016,pp 1-12